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Psycho-endocrine-immune response to mindfulness-based stress reduction in HIV-infected individuals
| Stress may hasten HIV disease progression by compromising immune response and increasing viral replication. Conversely, stress reduction may buffer effects of stress on HIV disease. This study determined the effects of an 8-week, mindfulness-based stress reduction (MBSR) program on perceived stress, mood, stress hormones, immune function, and health in HIV infected subjects. A synthesized conceptual framework of psychoneuroimmunology and a transactional model of stress guided the study. A quasi-experimental, repeated-measures, control group design was utilized. Subjects were non-randomly assigned to intervention or control group, and data were collected at baseline, 4 weeks, 8 weeks (immediately post-intervention), and 3 months post-intervention. At 8-weeks the MSBR group showed significant increases (p<0.05; T-test from baseline) in mood, functional health, and natural killer (NK) cell activity due to elevated NK cell numbers. These changes persisted at 3-months post-intervention. Control subjects showed no changes over time. Cortisol and DHEAS did not change in either group. These results provide empirical evidence to include stress reduction techniques in the comprehensive care of patients with HIV disease. |
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Primary Investigator
F. Patrick Robinson
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P.I. Institution Name
University of Illinois at Chicago
Title
Research Associate
Contact Address
College of Nursing, 845 South Damen Avenue, M/C 802, 405E NURS
Chicago, IL, 60612
USA
Contact E-mail
prphd@uic.edu
Contact Telephone
312.996.8217
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Secondary Investigators
Mathews, Herbert L
Janusek, Linda
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