Quality of Life After Adjuvant Intra-Arterial Chemotherapy and Radiotherapy in Resectable Pancreatic and Periampullary Cancer

2.50
Hdl Handle:
http://hdl.handle.net/10755/148443
Type:
Presentation
Title:
Quality of Life After Adjuvant Intra-Arterial Chemotherapy and Radiotherapy in Resectable Pancreatic and Periampullary Cancer
Abstract:
Quality of Life After Adjuvant Intra-Arterial Chemotherapy and Radiotherapy in Resectable Pancreatic and Periampullary Cancer
Conference Sponsor:Sigma Theta Tau International
Conference Year:2009
Author:Pek, Chulja J., RN, MN
P.I. Institution Name:Erasmus University Rotterdam
Title:Assistant Research Scientist
Co-Authors:Marjolein J. M. Morak, MD; Erwin J. O. Kompanje, PhD; Wim C. J. Hop, PhD; Geert Kazemier, MD, PhD; Casper H. J. Eijck, MD, PhD
[Clinical Session Presentation] Background: Adjuvant therapies in pancreatic and periampullary cancer have been shown to achieve only marginal survival benefit. In a randomized controlled trial, 120 patients with pancreatic or periampullary cancer after surgery received either adjuvant celiac axis infusion and radiotherapy (CAI/RT) or no adjuvant treatment.   Aim of the study:To compare Quality of Life (QoL) in patients receiving intra-arterial chemotherapy and radiotherapy (CAI/RT) after pancreatoduodenectomy with QoL in patients without postoperative adjuvant treatment.Methods:  During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) every 3 months during the first 24 months after randomisation. Results: Eighty-six per cent (n=103) of the patients completed one or more questionnaires, 51 in the treatment arm and 52 in the observation arm. In total, 355 questionnaires were completed. CAI/RT did not impair physical, emotional or social functioning. During and after CAI/ RT, patients had significantly less pain (p=0.02; mean difference 9.7 points) and significantly less nausea and vomiting (p=0.01; mean difference 5.9 points). Overall QoL (global functioning) tended to be better (p=0.08; mean difference 6.5 points) after CAI/RT. Conclusion: CAI/RT did not impair QoL after pancreatoduodenectomy for pancreatic or periampullary tumours and was even improved during the second half of the follow-up.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleQuality of Life After Adjuvant Intra-Arterial Chemotherapy and Radiotherapy in Resectable Pancreatic and Periampullary Canceren_GB
dc.identifier.urihttp://hdl.handle.net/10755/148443-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Quality of Life After Adjuvant Intra-Arterial Chemotherapy and Radiotherapy in Resectable Pancreatic and Periampullary Cancer</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2009</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Pek, Chulja J., RN, MN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Erasmus University Rotterdam</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Research Scientist</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">c.pek@erasmusmc.nl</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Marjolein J. M. Morak, MD; Erwin J. O. Kompanje, PhD; Wim C. J. Hop, PhD; Geert Kazemier, MD, PhD; Casper H. J. Eijck, MD, PhD</td></tr><tr><td colspan="2" class="item-abstract">[Clinical Session Presentation] Background: Adjuvant therapies in pancreatic and periampullary cancer have been shown to achieve only marginal survival benefit. In a randomized controlled trial, 120 patients with pancreatic or periampullary cancer after surgery received either adjuvant celiac axis infusion and radiotherapy (CAI/RT) or no adjuvant treatment.&nbsp;&nbsp; Aim of the study:To compare Quality of Life (QoL) in patients receiving intra-arterial chemotherapy and radiotherapy (CAI/RT) after pancreatoduodenectomy with QoL in patients without postoperative adjuvant treatment.Methods:&nbsp; During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) every 3 months during the first 24 months after randomisation. Results: Eighty-six per cent (n=103) of the patients completed one or more questionnaires, 51 in the treatment arm and 52 in the observation arm. In total, 355 questionnaires were completed. CAI/RT did not impair physical, emotional or social functioning. During and after CAI/ RT, patients had significantly less pain (p=0.02; mean difference 9.7 points) and significantly less nausea and vomiting (p=0.01; mean difference 5.9 points). Overall QoL (global functioning) tended to be better (p=0.08; mean difference 6.5 points) after CAI/RT. Conclusion: CAI/RT did not impair QoL after pancreatoduodenectomy for pancreatic or periampullary tumours and was even improved during the second half of the follow-up.</td></tr></table>en_GB
dc.date.available2011-10-26T09:45:13Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T09:45:13Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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