2.50
Hdl Handle:
http://hdl.handle.net/10755/148939
Type:
Presentation
Title:
Sustaining Medication Adherence in Patients with HIV/AIDS
Abstract:
Sustaining Medication Adherence in Patients with HIV/AIDS
Conference Sponsor:Sigma Theta Tau International
Conference Year:2005
Author:Erlen, Judith A., RN, PhD, FAAN
P.I. Institution Name:University of Pittsburgh School of Nursing
Title:professor
Co-Authors:Susan Sereika, PhD; Mary Pat Lewis, PhD, RN; Jacqueline Dunbar-Jacob, PhD, RN, FAAN; Susan Hunt, MD; Christopher M. Ryan, PhD; John Mellors, MD
Research with HIV/AIDS patients has focused mainly on identifying patterns of interventions to improve medication adherence. This research (R01 NR04749; P30 NR03924) addresses sustaining adherence beyond the length of the intervention. The purpose of the study was to examine the effect of a nurse delivered 16 week tapered telephone maintenance program based on social cognitive theory to antiretroviral therapy relative to usual care/control condition. The sample at baseline included 200 randomly assigned subjects with HIV/AIDS. Subjects were 67% males and 54% white; mean age was 40.6 years. Adherence was measured using electronic event monitors (EEMs) with insertion of events from diaries when patients ?pocket dosed?. Intent-to-treat approach using repeated measures analysis was used to assess adherence over time. Fifty-five (28%) subjects dropped out of the study between baseline and post-maintenance, with similar rates in the treatment and the control groups. While the intervention group showed modest improvement in change scores from post-intervention to post-maintenance, there were no significant differences between the control and intervention groups for adherence defined as prescribed doses, compliant days, missed days, optimum interval, and correct day and interval. The maximum number of maintenance sessions was eight; not all subjects received the total number of sessions. The mean number of maintenance sessions delivered was 5.2±3.3 sessions. Thirty-seven (38.9%) received all sessions; 23 (24.2%) did not receive any maintenance sessions. The lack of significant differences between groups may be due to the fact that all intervention subjects did not receive the full maintenance program. This study shows that attrition is difficult to prevent in a longitudinal study with HIV/AIDS subjects. Researchers need to identify issues related to attrition and develop strategies to minimize their effect when conducting a longitudinal study. In addition, there is a need to monitor adherence to the research protocol during an intervention study.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleSustaining Medication Adherence in Patients with HIV/AIDSen_GB
dc.identifier.urihttp://hdl.handle.net/10755/148939-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Sustaining Medication Adherence in Patients with HIV/AIDS</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2005</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Erlen, Judith A., RN, PhD, FAAN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Pittsburgh School of Nursing</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">professor</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">jae001@pitt.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Susan Sereika, PhD; Mary Pat Lewis, PhD, RN; Jacqueline Dunbar-Jacob, PhD, RN, FAAN; Susan Hunt, MD; Christopher M. Ryan, PhD; John Mellors, MD</td></tr><tr><td colspan="2" class="item-abstract">Research with HIV/AIDS patients has focused mainly on identifying patterns of interventions to improve medication adherence. This research (R01 NR04749; P30 NR03924) addresses sustaining adherence beyond the length of the intervention. The purpose of the study was to examine the effect of a nurse delivered 16 week tapered telephone maintenance program based on social cognitive theory to antiretroviral therapy relative to usual care/control condition. The sample at baseline included 200 randomly assigned subjects with HIV/AIDS. Subjects were 67% males and 54% white; mean age was 40.6 years. Adherence was measured using electronic event monitors (EEMs) with insertion of events from diaries when patients ?pocket dosed?. Intent-to-treat approach using repeated measures analysis was used to assess adherence over time. Fifty-five (28%) subjects dropped out of the study between baseline and post-maintenance, with similar rates in the treatment and the control groups. While the intervention group showed modest improvement in change scores from post-intervention to post-maintenance, there were no significant differences between the control and intervention groups for adherence defined as prescribed doses, compliant days, missed days, optimum interval, and correct day and interval. The maximum number of maintenance sessions was eight; not all subjects received the total number of sessions. The mean number of maintenance sessions delivered was 5.2&plusmn;3.3 sessions. Thirty-seven (38.9%) received all sessions; 23 (24.2%) did not receive any maintenance sessions. The lack of significant differences between groups may be due to the fact that all intervention subjects did not receive the full maintenance program. This study shows that attrition is difficult to prevent in a longitudinal study with HIV/AIDS subjects. Researchers need to identify issues related to attrition and develop strategies to minimize their effect when conducting a longitudinal study. In addition, there is a need to monitor adherence to the research protocol during an intervention study.</td></tr></table>en_GB
dc.date.available2011-10-26T09:53:15Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T09:53:15Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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