Polymorphism of the IL6 Gene Associated with Plasma IL6 and Physical Activity Levels

2.50
Hdl Handle:
http://hdl.handle.net/10755/150877
Type:
Presentation
Title:
Polymorphism of the IL6 Gene Associated with Plasma IL6 and Physical Activity Levels
Abstract:
Polymorphism of the IL6 Gene Associated with Plasma IL6 and Physical Activity Levels
Conference Sponsor:Sigma Theta Tau International
Conference Year:2011
Author:FitzGerald, Leah, PhD, FNP
P.I. Institution Name:UCLA
Title:Assistant Professor
[22nd International Nursing Research Congress - Research Presentation] Purpose: The aim of this study was to compare allelic and genotypic frequencies of the Interleukin-6 (IL6) -174 G>C and -572 G>C polymorphism and baseline plasma IL6 values between endurance athletes and healthy controls.  We hypothesized that IL6 would be influenced by allelic and genotypic frequencies and physical activity. IL6 plays a role in metabolism regulation during exercise and in mediating inflammation. Alternatively, enhanced plasma levels of IL6 represent a strong risk marker in chronic disorders. Genetic polymorphisms in IL6 gene promoter -174/-572 positions affect IL6 expression, human exercise performance, and health-related phenotype.    
Methods: Cross-sectional assessment on 61 serious endurance athletes and 90 healthy controls (aged 18 - 65 years old), included anthropometric measurements, DNA isolation and IL6 measurement.
Results: Allele distribution was in Hardy-Weinberg's equilibrium. There were significant overall group differences in IL6 levels (p <0.01) and athletes with -572 G>C allele had significantly lower logIL6 values (p=0.0) compared to controls.  Linear regression with logIL6 as the dependent variable and age, BMI, gender, and SNP's -174 and -572 as covariates and group as a fixed factor supports  age, (p = 0.04) BMI (p = 0.02), SNP -572 (p = 0.02), group (p < 0.01),  (-)572*gr interaction (p= 0.03) significant in predicting logIL6. Conclusion:
Higher levels of physical activity are associated with reduced levels of peripheral inflammatory mediators compared with a sedentary lifestyle.  Our findings suggest that the -572C allele may effect baseline plasma IL6 levels in athlete as well as age, BMI and activity level, suggesting there may be a genetically determined difference in the degree of the IL6 response to exercise stimuli between individuals.  An exercise-induced reduction in the proinflammatory burden may explain a part of the relation among regular physical activity and prevention in chronic disorders associated with systemic low-level inflammation.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titlePolymorphism of the IL6 Gene Associated with Plasma IL6 and Physical Activity Levelsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/150877-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Polymorphism of the IL6 Gene Associated with Plasma IL6 and Physical Activity Levels</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2011</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">FitzGerald, Leah, PhD, FNP</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">UCLA</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">lfitzger@sonnet.ucla.edu</td></tr><tr><td colspan="2" class="item-abstract">[22nd International Nursing Research Congress - Research Presentation] Purpose: The aim of this study was to compare allelic and genotypic frequencies of the Interleukin-6 (IL6) -174 G&gt;C and -572 G&gt;C polymorphism and baseline plasma IL6 values between endurance athletes and healthy controls. &nbsp;We hypothesized that IL6 would be influenced by allelic and genotypic frequencies and physical activity. IL6 plays a role in metabolism regulation during exercise and in mediating inflammation. Alternatively, enhanced plasma levels of IL6 represent a strong risk marker in chronic disorders. Genetic polymorphisms in IL6 gene promoter -174/-572 positions affect IL6 expression, human exercise performance, and health-related phenotype. &nbsp;&nbsp;&nbsp; <br/>Methods: Cross-sectional assessment on 61 serious endurance athletes and 90 healthy controls (aged 18 - 65 years old), included anthropometric measurements, DNA isolation and IL6 measurement. <br/>Results: Allele distribution was in Hardy-Weinberg's equilibrium. There were significant overall group differences in IL6 levels (p &lt;0.01) and athletes with -572 G&gt;C allele had significantly lower logIL6 values (p=0.0) compared to controls. &nbsp;Linear regression with logIL6 as the dependent variable and age, BMI, gender, and SNP's -174 and -572 as covariates and group as a fixed factor supports&nbsp; age, (p = 0.04) BMI (p = 0.02), SNP -572 (p = 0.02), group (p &lt; 0.01),&nbsp; (-)572*gr interaction (p= 0.03) significant in predicting logIL6. Conclusion: <br/>Higher levels of physical activity are associated with reduced levels of peripheral inflammatory mediators compared with a sedentary lifestyle.&nbsp; Our findings suggest that the -572C allele may effect baseline plasma IL6 levels in athlete as well as age, BMI and activity level, suggesting there may be a genetically determined difference in the degree of the IL6 response to exercise stimuli between individuals. &nbsp;An exercise-induced reduction in the proinflammatory burden may explain a part of the relation among regular physical activity and prevention in chronic disorders associated with systemic low-level inflammation.</td></tr></table>en_GB
dc.date.available2011-10-26T10:45:21Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T10:45:21Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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