2.50
Hdl Handle:
http://hdl.handle.net/10755/152298
Type:
Presentation
Title:
C-Reactive Protein and Cardiometabolic Risk among Africa-American Women
Abstract:
C-Reactive Protein and Cardiometabolic Risk among Africa-American Women
Conference Sponsor:Sigma Theta Tau International
Conference Year:2007
Author:Appel, Susan J., APRN, BC, PhD
P.I. Institution Name:University of Alabama at Birmingham
Title:Associate Professor
Co-Authors:Natalie A. Floyd, MSN, APRN, BC
[Research Presentation] The Purpose of this study was to determine early risk markers for CVD among healthy AA women ages 19-45. We hypothesized that AA women's risk was more closely associated with insulin sensitivity, inflammation and a prothrombotic state than dyslipidemia. Method: This study took place in the General Clinical Research Center of a southeastern medical center in the US, N=33. AA women age 19-45, were screened for metabolic syndrome and other CV risk factors in a fasting state and underwent a 2-hour OGTT. Then various criteria were compared to determine presence for the MS and other early risk markers for CVD. Findings: Interestingly, the NCEP guidelines only classifiedá n = 6 (15.8 %) women as possessing the MS. Whereas, the American Clinical Endocrinology criteria diagnosed n =12 (31.6%) as having MS. The most sensitive single predictor of CV risk was waist circumference which classified n = 18 (47.4 % ) ofá women being at risk. Similarly, BMI classified n =17 (44.7%) as being at risk in the overweight to obese categories. A regression equation produced a R2 of 0.68 using Plasminogen Activator Inhibitor-1 (PAI-1) as the dependent variable with the predictors of fasting glucose, CRP, and waist circumference; waist circumference was predicted by PAI-1 with an R2 of 0.58 and C-Reactive Protein (CRP) was predicted by post-glucose with an R2 of 0.50. Discussion: As identified in the literature AA women's risk for CVD is likely significantly underestimated based on the sole use of NCEP criteria. Clinicians should consider a broader definition of risk than contained within the NCEP criteria. The inclusion of markers of inflammation (CRP) and prothrombotic factors (PAI-1) along with measures of insulin sensitivity may add to early detection of CVD risk, and ultimate reduction in the CV health disparities of these AA women.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleC-Reactive Protein and Cardiometabolic Risk among Africa-American Womenen_GB
dc.identifier.urihttp://hdl.handle.net/10755/152298-
dc.description.abstract<table><tr><td colspan="2" class="item-title">C-Reactive Protein and Cardiometabolic Risk among Africa-American Women</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2007</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Appel, Susan J., APRN, BC, PhD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Alabama at Birmingham</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Associate Professor</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">sappel@uab.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Natalie A. Floyd, MSN, APRN, BC</td></tr><tr><td colspan="2" class="item-abstract">[Research Presentation] The Purpose of this study was to determine early risk markers for CVD among healthy AA women ages 19-45. We hypothesized that AA women's risk was more closely associated with insulin sensitivity, inflammation and a prothrombotic state than dyslipidemia. Method: This study took place in the General Clinical Research Center of a southeastern medical center in the US, N=33. AA women age 19-45, were screened for metabolic syndrome and other CV risk factors in a fasting state and underwent a 2-hour OGTT. Then various criteria were compared to determine presence for the MS and other early risk markers for CVD. Findings: Interestingly, the NCEP guidelines only classified&aacute; n = 6 (15.8 %) women as possessing the MS. Whereas, the American Clinical Endocrinology criteria diagnosed n =12 (31.6%) as having MS. The most sensitive single predictor of CV risk was waist circumference which classified n = 18 (47.4 % ) of&aacute; women being at risk. Similarly, BMI classified n =17 (44.7%) as being at risk in the overweight to obese categories. A regression equation produced a R2 of 0.68 using Plasminogen Activator Inhibitor-1 (PAI-1) as the dependent variable with the predictors of fasting glucose, CRP, and waist circumference; waist circumference was predicted by PAI-1 with an R2 of 0.58 and C-Reactive Protein (CRP) was predicted by post-glucose with an R2 of 0.50. Discussion: As identified in the literature AA women's risk for CVD is likely significantly underestimated based on the sole use of NCEP criteria. Clinicians should consider a broader definition of risk than contained within the NCEP criteria. The inclusion of markers of inflammation (CRP) and prothrombotic factors (PAI-1) along with measures of insulin sensitivity may add to early detection of CVD risk, and ultimate reduction in the CV health disparities of these AA women.</td></tr></table>en_GB
dc.date.available2011-10-26T11:31:04Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T11:31:04Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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