Pathophysiological Changes Associated with the Exposure of Sustained Delivery of Glucocorticoids on Pituitary Adenoma Cell Line

2.50
Hdl Handle:
http://hdl.handle.net/10755/152464
Type:
Presentation
Title:
Pathophysiological Changes Associated with the Exposure of Sustained Delivery of Glucocorticoids on Pituitary Adenoma Cell Line
Abstract:
Pathophysiological Changes Associated with the Exposure of Sustained Delivery of Glucocorticoids on Pituitary Adenoma Cell Line
Conference Sponsor:Sigma Theta Tau International
Conference Year:2006
Author:Haynie, Lisa A., PhD, RN, CFNP
P.I. Institution Name:University of Mississippi Medical Center
Title:Assistant Professor of Nursing
Co-Authors:Hamed A. Benghuzzi, PhD; Michelle A. Tucci, PhD
Glucocorticoid receptor rich tissues such as pituitary cells express tissue specific 11 ? hydroxysteroid type 1 enzyme, which causes cortisol to act as an autocrine, anti-proliferative, pro-differentiation stimulus in normal tissue. In pituitary tumor cells there is a strong correlation indicating a shift from 11 ? hydroxysteroid type 1 enzyme activity to 11 ? hydroxysteroid type 2 enzyme activity. Shifting causes an anti-proliferative effect, which may be effective in suppressing tumor activity. Overall, the results indicated a decreased in cell number for both acute and chronic administration over a 96 hour period without inducing cellular damage (MDA), reactive nitric intermediates (nitric oxide) or reducing cellular antioxidant status (glutathione). Cortisol administration caused an increase in the number of hyperchromic nuclei suggesting cell cycle regulation. These findings conclude that cortisol administration to pituitary tumor cells may offer a future means of treatment for patients post hypophysectomy.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titlePathophysiological Changes Associated with the Exposure of Sustained Delivery of Glucocorticoids on Pituitary Adenoma Cell Lineen_GB
dc.identifier.urihttp://hdl.handle.net/10755/152464-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Pathophysiological Changes Associated with the Exposure of Sustained Delivery of Glucocorticoids on Pituitary Adenoma Cell Line</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2006</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Haynie, Lisa A., PhD, RN, CFNP</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Mississippi Medical Center</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor of Nursing</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">lhaynie@son.umsmed.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Hamed A. Benghuzzi, PhD; Michelle A. Tucci, PhD</td></tr><tr><td colspan="2" class="item-abstract">Glucocorticoid receptor rich tissues such as pituitary cells express tissue specific 11 ? hydroxysteroid type 1 enzyme, which causes cortisol to act as an autocrine, anti-proliferative, pro-differentiation stimulus in normal tissue. In pituitary tumor cells there is a strong correlation indicating a shift from 11 ? hydroxysteroid type 1 enzyme activity to 11 ? hydroxysteroid type 2 enzyme activity. Shifting causes an anti-proliferative effect, which may be effective in suppressing tumor activity. Overall, the results indicated a decreased in cell number for both acute and chronic administration over a 96 hour period without inducing cellular damage (MDA), reactive nitric intermediates (nitric oxide) or reducing cellular antioxidant status (glutathione). Cortisol administration caused an increase in the number of hyperchromic nuclei suggesting cell cycle regulation. These findings conclude that cortisol administration to pituitary tumor cells may offer a future means of treatment for patients post hypophysectomy.</td></tr></table>en_GB
dc.date.available2011-10-26T11:37:18Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T11:37:18Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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