2.50
Hdl Handle:
http://hdl.handle.net/10755/152618
Type:
Presentation
Title:
Serum Biomarkers, Depressive Symptoms, and Heart Failure
Abstract:
Serum Biomarkers, Depressive Symptoms, and Heart Failure
Conference Sponsor:Sigma Theta Tau International
Conference Year:2005
Author:Salman, Ali, MD, RN
P.I. Institution Name:Case Western Reserve University
Co-Authors:Yi-Hui Lee, MSN, RN; Rabab Salman, MD, MS; Joyce J. Fitzpatrick, RN, PhD, MBA, FAAN
Heart failure (HF) is a chronic clinical syndrome, resulting from many disorders that interfere with cardiac function. It may be coupled with clinically relevant psychological impairments such as depression, anxiety, and anger. The American Heart Association (2002) has estimated that more than 4,900,000 American currently have HF. Moreover, HF and depression are associated with many immunologic and functional changes that evolve at different physiologic and anatomic levels. Numerous studies have shown that HF is associated with elevated plasma levels of pro-inflammatory cytokines IL-6, TNF-alpha which increases as NYHA heart failure functional class worsens. Also, the recent research shows that clinically depressed patients have elevated levels of pro-inflammatory risk markers that have been implicated in HF pathogenesis. However, the relationship between depressive symptoms and pro-inflammatory cytokines levels in HF patients has not been studied yet. Therefore, a correlational descriptive study of a convenience sample of 100 adults with HF, ages 21 and older, will be used to examine the relationship between pro-inflammatory cytokines and depressive symptoms. The plasma levels of the pro-inflammatory cytokines IL-6, TNF-alpha will be measured by using commercially available immunoassay kits which utilize the quantitative sandwich enzyme immunoassay technique. The Center for Epidemiologic Studies Depression Scale is a measure of depressive symptoms and mood status rather than of clinical depression will be used in this study. Pearson correlation Coefficient will be used to examine the strength of the relationship between circulating cytokine levels and depressive symptoms in HF patients. A regression analysis will be performed to establish the predictive value of cytokine levels, gender, BMI and age in determining severity of depressive symptoms. This study will enhance our understanding about the relationship between serum biomarkers and depressive symptoms in HF patients. It will also stimulate further research and assist in developing appropriate interventions for improving HF patients' outcomes.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleSerum Biomarkers, Depressive Symptoms, and Heart Failureen_GB
dc.identifier.urihttp://hdl.handle.net/10755/152618-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Serum Biomarkers, Depressive Symptoms, and Heart Failure</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2005</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Salman, Ali, MD, RN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Case Western Reserve University</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">axs48@case.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Yi-Hui Lee, MSN, RN; Rabab Salman, MD, MS; Joyce J. Fitzpatrick, RN, PhD, MBA, FAAN</td></tr><tr><td colspan="2" class="item-abstract">Heart failure (HF) is a chronic clinical syndrome, resulting from many disorders that interfere with cardiac function. It may be coupled with clinically relevant psychological impairments such as depression, anxiety, and anger. The American Heart Association (2002) has estimated that more than 4,900,000 American currently have HF. Moreover, HF and depression are associated with many immunologic and functional changes that evolve at different physiologic and anatomic levels. Numerous studies have shown that HF is associated with elevated plasma levels of pro-inflammatory cytokines IL-6, TNF-alpha which increases as NYHA heart failure functional class worsens. Also, the recent research shows that clinically depressed patients have elevated levels of pro-inflammatory risk markers that have been implicated in HF pathogenesis. However, the relationship between depressive symptoms and pro-inflammatory cytokines levels in HF patients has not been studied yet. Therefore, a correlational descriptive study of a convenience sample of 100 adults with HF, ages 21 and older, will be used to examine the relationship between pro-inflammatory cytokines and depressive symptoms. The plasma levels of the pro-inflammatory cytokines IL-6, TNF-alpha will be measured by using commercially available immunoassay kits which utilize the quantitative sandwich enzyme immunoassay technique. The Center for Epidemiologic Studies Depression Scale is a measure of depressive symptoms and mood status rather than of clinical depression will be used in this study. Pearson correlation Coefficient will be used to examine the strength of the relationship between circulating cytokine levels and depressive symptoms in HF patients. A regression analysis will be performed to establish the predictive value of cytokine levels, gender, BMI and age in determining severity of depressive symptoms. This study will enhance our understanding about the relationship between serum biomarkers and depressive symptoms in HF patients. It will also stimulate further research and assist in developing appropriate interventions for improving HF patients' outcomes.</td></tr></table>en_GB
dc.date.available2011-10-26T11:43:06Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T11:43:06Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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