Improving Functional Capacity and Health Status in HIV Using Exercise and Oxandrolone

2.50
Hdl Handle:
http://hdl.handle.net/10755/154468
Type:
Presentation
Title:
Improving Functional Capacity and Health Status in HIV Using Exercise and Oxandrolone
Abstract:
Improving Functional Capacity and Health Status in HIV Using Exercise and Oxandrolone
Conference Sponsor:Sigma Theta Tau International
Conference Year:2005
Author:Smith, Barbara, PhD, RN, FAAN
P.I. Institution Name:University of Maryland, Baltimore
Title:Professor and Associate Dean for Research
Co-Authors:James L. Raper, DNS, CFNP; Michael Weaver, PhD
Objectives. Today in developed countries, HIV is viewed more as a chronic illness because of potent antiretroviral therapy and prophylaxis against opportunistic infections. However, despite treatment successes, there has been the emergence of new side effects that negatively impact functional capacity and health status including quality of life (QOL). The aim of this study was to examine the effects of exercise and oxandrolone on functional capacity measured by time on treadmill (TOT) and health status measured by the MOS-HIV in HIV infected adults. Methods. Subjects were randomly assigned to oxandrolone+exercise or oxandrolone placebo+exercise. At baseline and week 12 we measured certain demographic variables, TOT and health status. Results. Functional capacity (TOT) increased by 32% (3 minutes) in the oxandrolone+exercise group which was greater than the increase observed in the placebo+exercise group (F[GroupXTime] =5.5, p=0.03). Using a regression model including TOT, group, and age as predictors of a change in MOS-HIV subscales, only Health Distress showed a greater improvement in the oxandrolone+exercise group (F=7.4, p=0.01). Although there was no difference between the groups in change in Vitality (F=0.11, p=0.75) or QOL (F=0.10, p=0.75), there was a trend toward a greater increase in Vitality (F=3.8, p=0.07) and QOL (F=3.4, p=0.08) with an increase in TOT. In addition, there was a trend in older subjects toward an increase in Vitality (F=3.5, p=0.08) and QOL (F=3.6, p=0.08) for a given increase in TOT. Conclusions. Subjects in both groups benefited from this intervention. Those who received oxandrolone+exercise had the added benefit of an increase in functional capacity as measured by TOT; however, other than an improved Health Distress score, oxandrolone+exercise had little impact over placebo+exercise on other MOS-HIV subscales.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleImproving Functional Capacity and Health Status in HIV Using Exercise and Oxandroloneen_GB
dc.identifier.urihttp://hdl.handle.net/10755/154468-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Improving Functional Capacity and Health Status in HIV Using Exercise and Oxandrolone</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2005</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Smith, Barbara, PhD, RN, FAAN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Maryland, Baltimore</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Professor and Associate Dean for Research</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">bsmith@son.umaryland.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">James L. Raper, DNS, CFNP; Michael Weaver, PhD</td></tr><tr><td colspan="2" class="item-abstract">Objectives. Today in developed countries, HIV is viewed more as a chronic illness because of potent antiretroviral therapy and prophylaxis against opportunistic infections. However, despite treatment successes, there has been the emergence of new side effects that negatively impact functional capacity and health status including quality of life (QOL). The aim of this study was to examine the effects of exercise and oxandrolone on functional capacity measured by time on treadmill (TOT) and health status measured by the MOS-HIV in HIV infected adults. Methods. Subjects were randomly assigned to oxandrolone+exercise or oxandrolone placebo+exercise. At baseline and week 12 we measured certain demographic variables, TOT and health status. Results. Functional capacity (TOT) increased by 32% (3 minutes) in the oxandrolone+exercise group which was greater than the increase observed in the placebo+exercise group (F[GroupXTime] =5.5, p=0.03). Using a regression model including TOT, group, and age as predictors of a change in MOS-HIV subscales, only Health Distress showed a greater improvement in the oxandrolone+exercise group (F=7.4, p=0.01). Although there was no difference between the groups in change in Vitality (F=0.11, p=0.75) or QOL (F=0.10, p=0.75), there was a trend toward a greater increase in Vitality (F=3.8, p=0.07) and QOL (F=3.4, p=0.08) with an increase in TOT. In addition, there was a trend in older subjects toward an increase in Vitality (F=3.5, p=0.08) and QOL (F=3.6, p=0.08) for a given increase in TOT. Conclusions. Subjects in both groups benefited from this intervention. Those who received oxandrolone+exercise had the added benefit of an increase in functional capacity as measured by TOT; however, other than an improved Health Distress score, oxandrolone+exercise had little impact over placebo+exercise on other MOS-HIV subscales.</td></tr></table>en_GB
dc.date.available2011-10-26T13:01:22Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T13:01:22Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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