Anxiolytic Effects of L-Theanine: A Component of Green Tea, when Combined with Midazolam, in the Male Sprague-Dawley Rat

2.50
Hdl Handle:
http://hdl.handle.net/10755/154920
Type:
Presentation
Title:
Anxiolytic Effects of L-Theanine: A Component of Green Tea, when Combined with Midazolam, in the Male Sprague-Dawley Rat
Abstract:
Anxiolytic Effects of L-Theanine: A Component of Green Tea, when Combined with Midazolam, in the Male Sprague-Dawley Rat
Conference Sponsor:Sigma Theta Tau International
Conference Year:2010
Author:Ceremuga, Thomas E., BA, BSN, MSN, PhD
P.I. Institution Name:US Army Graduate Program in Anesthesia Nursing
Title:Associate Professor
21st INRC [Research Presentation] Purpose: The purpose of this study was to determine if the green tea compound, L-theanine, has anxiolytic effects in the laboratory rat.ÿ Additionally the study investigated the effects of L-theanine at the GABAA receptor in the central nervous system.ÿ The research questions were: 1) Does L-theanine (a green tea compound) have anxiolytic effects in the laboratory rat? and 2) if there is an anxiolytic effect, is the anxiolytic effect of L-theanine a result of modulation of the benzodiazepine site on the GABAA receptor? Methods: A five group prospective study using an experimental between groups design was used. Fifty-five rats were divided into five groups: control; L-theanine; midazolam (positive control); flumazenil plus L-theanine; and midazolam plus L-theanine. The behavioral component of anxiety was evaluated using the elevated plus maze.ÿ Data analysis was performed using a two-tailed Multivariate Analysis of Variance (MANOVA) and Sheffe post-hoc test. Results: Data suggest that L-theanine does not produce anxiolysis by modulation of the GABAA receptor; however, in combination with midazolam, a synergistic or additive effect was demonstrated by decreased anxiety, motor movements and locomotion. Conclusion: L-theanine may affect anxiety and movement.ÿ Future experiments should explore anxiolytic and motor effects of L-theanine using other balance and locomotion instruments such as the rotorod.ÿ Additional studies might include investigating the effects of L-theanine at glutamatergic receptors and at the neuromuscular junction.ÿ As evidenced by this research, the use of herbals such as L-theanine (a green tea compound) may haveÿimportant interactions with other medications (e.g., midazolam) and may result in ÿsignificant adverse effects.ÿ These data may provide direction for further studies examining L-theanine and its effects on anxiety and motor activity, a concern for healthcare providers whose patients are consuming green tea.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleAnxiolytic Effects of L-Theanine: A Component of Green Tea, when Combined with Midazolam, in the Male Sprague-Dawley Raten_GB
dc.identifier.urihttp://hdl.handle.net/10755/154920-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Anxiolytic Effects of L-Theanine: A Component of Green Tea, when Combined with Midazolam, in the Male Sprague-Dawley Rat</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2010</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Ceremuga, Thomas E., BA, BSN, MSN, PhD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">US Army Graduate Program in Anesthesia Nursing</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Associate Professor</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">thomas.ceremuga@amedd.army.mil</td></tr><tr><td colspan="2" class="item-abstract">21st INRC [Research Presentation] Purpose: The purpose of this study was to determine if the green tea compound, L-theanine, has anxiolytic effects in the laboratory rat.&yuml; Additionally the study investigated the effects of L-theanine at the GABAA receptor in the central nervous system.&yuml; The research questions were: 1) Does L-theanine (a green tea compound) have anxiolytic effects in the laboratory rat? and 2) if there is an anxiolytic effect, is the anxiolytic effect of L-theanine a result of modulation of the benzodiazepine site on the GABAA receptor? Methods: A five group prospective study using an experimental between groups design was used. Fifty-five rats were divided into five groups: control; L-theanine; midazolam (positive control); flumazenil plus L-theanine; and midazolam plus L-theanine. The behavioral component of anxiety was evaluated using the elevated plus maze.&yuml; Data analysis was performed using a two-tailed Multivariate Analysis of Variance (MANOVA) and Sheffe post-hoc test. Results: Data suggest that L-theanine does not produce anxiolysis by modulation of the GABAA receptor; however, in combination with midazolam, a synergistic or additive effect was demonstrated by decreased anxiety, motor movements and locomotion. Conclusion: L-theanine may affect anxiety and movement.&yuml; Future experiments should explore anxiolytic and motor effects of L-theanine using other balance and locomotion instruments such as the rotorod.&yuml; Additional studies might include investigating the effects of L-theanine at glutamatergic receptors and at the neuromuscular junction.&yuml; As evidenced by this research, the use of herbals such as L-theanine (a green tea compound) may have&yuml;important interactions with other medications (e.g., midazolam) and may result in &yuml;significant adverse effects.&yuml; These data may provide direction for further studies examining L-theanine and its effects on anxiety and motor activity, a concern for healthcare providers whose patients are consuming green tea.</td></tr></table>en_GB
dc.date.available2011-10-26T13:23:08Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T13:23:08Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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