2.50
Hdl Handle:
http://hdl.handle.net/10755/155797
Type:
Presentation
Title:
HIV Antiretroviral Treatment
Abstract:
HIV Antiretroviral Treatment
Conference Sponsor:Sigma Theta Tau International
Conference Year:2003
Conference Date:July 10-12, 2003
Author:George, Safiya, MSN, APRN
P.I. Institution Name:Emory University
Objective: The goal of this paper is to provide scientifically-based treatment guidelines for mid-level health care providers for the initiation of antiretroviral therapy in HIV-positive adults.Design: An in-depth literature review was done of HIV clinical drug trial research reports and studies within scholarly health journals from 1997-2000. A comparative design was used to evaluate and compare the efficacies and adverse effects of antiretroviral treatments studied. Population, Sample, Setting, Years: Within the studies reviewed, the populations included HIV-positive men and women, however, most studies only included treatment-naïve individuals. Most of the studies occurred in multiple healthcare settings and occurred over several years, varying from 1995-2000. Intervention and Outcome Variables: The intervention variable being studied was antiretroviral therapy. The outcome variables for each study included HIV viral load and CD4 count. Methods: A literature review and a comparative analysis of the studies was conducted. Then a table was generated to reflect antiretrovirals being studied, the sample, methodology, findings, and limitations. A written management protocol was developed for mid level providers based on the research findings and the Department of Health and Human Services 2001 guidelines. Findings: Patients less than forty years old, who frequently missed clinic appointments, and injection drug-users were more at risk for treatment failure. Combinations of either, two nucleoside reverse-transcriptase-inhibitors (NRTI’s) and one protease inhibitor (PI) or two NRTI’s and a non-nucleoside reverse-transcriptase-inhibitor (NNRTI) demonstrated the greatest potency in producing a durable virologic response. Indinavir is a PI that was able to produce a favorable response with fewer side effects than other PI’s. Conclusions: There are many non-medical factors to be considered before the initiation of antiretroviral therapy. HAART combinations of more than two NRTI’s have the greatest ability to produce a potent, sustained virologic response, decreasing viral loads to undetectable levels, especially when used as first-line therapy.
Repository Posting Date:
26-Oct-2011
Date of Publication:
10-Jul-2003
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleHIV Antiretroviral Treatmenten_GB
dc.identifier.urihttp://hdl.handle.net/10755/155797-
dc.description.abstract<table><tr><td colspan="2" class="item-title">HIV Antiretroviral Treatment</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2003</td></tr><tr class="item-conference-date"><td class="label">Conference Date:</td><td class="value">July 10-12, 2003</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">George, Safiya, MSN, APRN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Emory University</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">tendaz@hotmail.com</td></tr><tr><td colspan="2" class="item-abstract">Objective: The goal of this paper is to provide scientifically-based treatment guidelines for mid-level health care providers for the initiation of antiretroviral therapy in HIV-positive adults.Design: An in-depth literature review was done of HIV clinical drug trial research reports and studies within scholarly health journals from 1997-2000. A comparative design was used to evaluate and compare the efficacies and adverse effects of antiretroviral treatments studied. Population, Sample, Setting, Years: Within the studies reviewed, the populations included HIV-positive men and women, however, most studies only included treatment-na&iuml;ve individuals. Most of the studies occurred in multiple healthcare settings and occurred over several years, varying from 1995-2000. Intervention and Outcome Variables: The intervention variable being studied was antiretroviral therapy. The outcome variables for each study included HIV viral load and CD4 count. Methods: A literature review and a comparative analysis of the studies was conducted. Then a table was generated to reflect antiretrovirals being studied, the sample, methodology, findings, and limitations. A written management protocol was developed for mid level providers based on the research findings and the Department of Health and Human Services 2001 guidelines. Findings: Patients less than forty years old, who frequently missed clinic appointments, and injection drug-users were more at risk for treatment failure. Combinations of either, two nucleoside reverse-transcriptase-inhibitors (NRTI&rsquo;s) and one protease inhibitor (PI) or two NRTI&rsquo;s and a non-nucleoside reverse-transcriptase-inhibitor (NNRTI) demonstrated the greatest potency in producing a durable virologic response. Indinavir is a PI that was able to produce a favorable response with fewer side effects than other PI&rsquo;s. Conclusions: There are many non-medical factors to be considered before the initiation of antiretroviral therapy. HAART combinations of more than two NRTI&rsquo;s have the greatest ability to produce a potent, sustained virologic response, decreasing viral loads to undetectable levels, especially when used as first-line therapy.</td></tr></table>en_GB
dc.date.available2011-10-26T14:10:59Z-
dc.date.issued2003-07-10en_GB
dc.date.accessioned2011-10-26T14:10:59Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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