2.50
Hdl Handle:
http://hdl.handle.net/10755/155803
Type:
Presentation
Title:
Arginine and Immune Status in Elderly with Pressure Ulcers
Abstract:
Arginine and Immune Status in Elderly with Pressure Ulcers
Conference Sponsor:Sigma Theta Tau International
Conference Year:2003
Conference Date:July 10-12, 2003
Author:Stechmiller, Joyce
P.I. Institution Name:College of Nursing, University of Florida
Title:
Co-Authors:Bobbi Langkamp-Henken
The amino acid arginine enhances immune function and the healing of artificial wounds in healthy adult populations, but few studies have examined its effect among elderly nursing home residents with pressure ulcers. Purpose: The purpose of this study is to determine the effect of arginine supplementation on in vivo and in vitro immune parameters in nursing home elders with pressure ulcers and to examine the role of nitric oxide in arginine-modulated immune function. One mechanism by which arginine modulates immune function is by serving as a substrate for nitric oxide production. Nitric oxide, which is important in bacterial killing, inhibits lymphocyte proliferation and may be responsible for the attenuated proliferation response observed in our preliminary studies in the nursing home residents with pressure ulcers who received 8.5 or 17 g of supplemental arginine per day. Method: Nursing home residents (> 65 years of age) with one or more pressure ulcers will be randomized to one of two groups (n=15 per group). One group will receive 8.5 g of supplemental arginine and the other group will receive an isonitrogenous amount of a standard protein powder mixed in cherry syrup for 4 weeks. Immune function will be measured by assessing mitogen-induced lymphocyte proliferation, delayed type hypersensitivity, and incidence of infection prior to supplementation (baseline), 4 weeks post supplementation and after a washout period (10 weeks post-supplementation). Nitric oxide production will be measured in the presence and absence of a nitric oxide inhibitor in stimulated lymphocyte cultures. Nutritional status will also be assessed at baseline, week 4, and week 10. Findings: Study to be completed Spring, 2003. Discussion: This research will contribute to an understanding of the role of nutritional supplementation in preventing or treating pressure ulcers in elderly populations. <!--Abstract 13258 modified by 134.68.166.31 on 1-27-2003-->
Repository Posting Date:
26-Oct-2011
Date of Publication:
10-Jul-2003
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleArginine and Immune Status in Elderly with Pressure Ulcersen_GB
dc.identifier.urihttp://hdl.handle.net/10755/155803-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Arginine and Immune Status in Elderly with Pressure Ulcers</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2003</td></tr><tr class="item-conference-date"><td class="label">Conference Date:</td><td class="value">July 10-12, 2003</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Stechmiller, Joyce</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">College of Nursing, University of Florida</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value"> </td></tr><tr class="item-email"><td class="label">Email:</td><td class="value"> </td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Bobbi Langkamp-Henken</td></tr><tr><td colspan="2" class="item-abstract">The amino acid arginine enhances immune function and the healing of artificial wounds in healthy adult populations, but few studies have examined its effect among elderly nursing home residents with pressure ulcers. Purpose: The purpose of this study is to determine the effect of arginine supplementation on in vivo and in vitro immune parameters in nursing home elders with pressure ulcers and to examine the role of nitric oxide in arginine-modulated immune function. One mechanism by which arginine modulates immune function is by serving as a substrate for nitric oxide production. Nitric oxide, which is important in bacterial killing, inhibits lymphocyte proliferation and may be responsible for the attenuated proliferation response observed in our preliminary studies in the nursing home residents with pressure ulcers who received 8.5 or 17 g of supplemental arginine per day. Method: Nursing home residents (&gt; 65 years of age) with one or more pressure ulcers will be randomized to one of two groups (n=15 per group). One group will receive 8.5 g of supplemental arginine and the other group will receive an isonitrogenous amount of a standard protein powder mixed in cherry syrup for 4 weeks. Immune function will be measured by assessing mitogen-induced lymphocyte proliferation, delayed type hypersensitivity, and incidence of infection prior to supplementation (baseline), 4 weeks post supplementation and after a washout period (10 weeks post-supplementation). Nitric oxide production will be measured in the presence and absence of a nitric oxide inhibitor in stimulated lymphocyte cultures. Nutritional status will also be assessed at baseline, week 4, and week 10. Findings: Study to be completed Spring, 2003. Discussion: This research will contribute to an understanding of the role of nutritional supplementation in preventing or treating pressure ulcers in elderly populations. &lt;!--Abstract 13258 modified by 134.68.166.31 on 1-27-2003--&gt;</td></tr></table>en_GB
dc.date.available2011-10-26T14:11:19Z-
dc.date.issued2003-07-10en_GB
dc.date.accessioned2011-10-26T14:11:19Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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