2.50
Hdl Handle:
http://hdl.handle.net/10755/156077
Type:
Presentation
Title:
Cytokines May Be Associated with Cognitive Function in Heart Failure
Abstract:
Cytokines May Be Associated with Cognitive Function in Heart Failure
Conference Sponsor:Sigma Theta Tau International
Conference Year:2010
Author:Athilingam, Ponrathi R., PhD, RN, ACNP
P.I. Institution Name:University of Rochester
Title:Assistant Professor Clinical Nursing
Co-Authors:Leway Chen, MD, MPH, FACC; Jan A. Moynihan, PhD
21st INRC [Research Presentation] Purpose: During the past century, both the causes and treatment of heart failure (HF) have changed considerable. Biologically active molecules known as the cytokines are used for prognostification of HF.ÿ It is unclear whether these cytokines are associated with cognitive deficits in patients with HF. A recent research indicated fourfold risk of having cognitive deficit among HF patients compared to general population. The purpose of this study was to examine the relationship between cytokines and cognitive function in HF. Methods: A cross sectional study enrolled 38 community dwelling adults aged 50 and above with HF. ÿMini Mental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to measure cognitive function and blood samples collected for cytokines (i.e., Tumor necrosis factor (TNF- alfa), Interleukin (IL6), and C-reactive protein (CRP). ÿResults: Most participants were men (68%), Caucasian (79%), aged 50 to 89 (62 +/- 9 years), 62% were in NYHA class II, 38% in class III, 80% were in AHA/ACC stage C, 79% with ejection fraction <40%. The MoCA identified 61% participants with mild cognitive impairment with score <26 and 16% with moderate cognitive impairment score <22 with a mean score of 24.86 (SD +/- 2.81) compared to 2.2% on the MMSE with a mean score of 28.96 (SD +/- 1.9). Multiple regression analysis demonstrated no statistically significant association with cognitive function measured by MMSE and MoCA. Although not statistically significant, the cognitive function measured by MoCA was inversely related to TNF-alfa, IL-6, and CRP (r=0.24, p= 0.18). ÿCRP and IL-6 were highly related to each other (r .791, p= 0.0001). Conclusion: An appropriately designed longitudinal study may have potential to demonstrate a significant relationship between cognitive function and cytokines. In turn, this may help in early recognition of cognitive impairment and in the design of an intervention to enhance cognitive function.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleCytokines May Be Associated with Cognitive Function in Heart Failureen_GB
dc.identifier.urihttp://hdl.handle.net/10755/156077-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Cytokines May Be Associated with Cognitive Function in Heart Failure</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2010</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Athilingam, Ponrathi R., PhD, RN, ACNP</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Rochester</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor Clinical Nursing</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">ponrathi_athilingam@urmc.rochester.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Leway Chen, MD, MPH, FACC; Jan A. Moynihan, PhD</td></tr><tr><td colspan="2" class="item-abstract">21st INRC [Research Presentation] Purpose: During the past century, both the causes and treatment of heart failure (HF) have changed considerable. Biologically active molecules known as the cytokines are used for prognostification of HF.&yuml; It is unclear whether these cytokines are associated with cognitive deficits in patients with HF. A recent research indicated fourfold risk of having cognitive deficit among HF patients compared to general population. The purpose of this study was to examine the relationship between cytokines and cognitive function in HF. Methods: A cross sectional study enrolled 38 community dwelling adults aged 50 and above with HF. &yuml;Mini Mental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to measure cognitive function and blood samples collected for cytokines (i.e., Tumor necrosis factor (TNF- alfa), Interleukin (IL6), and C-reactive protein (CRP). &yuml;Results: Most participants were men (68%), Caucasian (79%), aged 50 to 89 (62 +/- 9 years), 62% were in NYHA class II, 38% in class III, 80% were in AHA/ACC stage C, 79% with ejection fraction &lt;40%. The MoCA identified 61% participants with mild cognitive impairment with score &lt;26 and 16% with moderate cognitive impairment score &lt;22 with a mean score of 24.86 (SD +/- 2.81) compared to 2.2% on the MMSE with a mean score of 28.96 (SD +/- 1.9). Multiple regression analysis demonstrated no statistically significant association with cognitive function measured by MMSE and MoCA. Although not statistically significant, the cognitive function measured by MoCA was inversely related to TNF-alfa, IL-6, and CRP (r=0.24, p= 0.18). &yuml;CRP and IL-6 were highly related to each other (r .791, p= 0.0001). Conclusion: An appropriately designed longitudinal study may have potential to demonstrate a significant relationship between cognitive function and cytokines. In turn, this may help in early recognition of cognitive impairment and in the design of an intervention to enhance cognitive function.</td></tr></table>en_GB
dc.date.available2011-10-26T14:25:56Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T14:25:56Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.