Arginine Supplementation Enhances Mitogen-Induced Lymphocyte Proliferation in Elderly Nursing Home Residents With Pressure Ulcers

2.50
Hdl Handle:
http://hdl.handle.net/10755/156724
Type:
Presentation
Title:
Arginine Supplementation Enhances Mitogen-Induced Lymphocyte Proliferation in Elderly Nursing Home Residents With Pressure Ulcers
Abstract:
Arginine Supplementation Enhances Mitogen-Induced Lymphocyte Proliferation in Elderly Nursing Home Residents With Pressure Ulcers
Conference Sponsor:Sigma Theta Tau International
Conference Year:2004
Conference Date:July 22-24, 2004
Author:Stechmiller, Joyce, ARNP, PhD, CS
P.I. Institution Name:University of Florida College of Nursing
Title:Associate Professor
Co-Authors:Bobbi Langkamp-Henken, PhD, RD
Arginine supplementation enhances mitogen-induced lymphoctye proliferation in elderly nursing home residents with pressure ulcers Immune function, nutrition, wound healing Objective: The purpose of this study was to determine the effect of arginine supplementation on in vivo and in vitro immune parameters in nursing home elders with pressure ulcers. Design: Experimental double blind controlled randomized study. Population, Sample, Setting, Years: Twenty six nursing home residents (> 65 years of age) with one or more pressure ulcers were randomized to one of two groups from 2001-2003. Methods: One group received 8.5 g of supplemental arginine and the other group received an isonitrogenous amount of a standard protein powder mixed in cherry syrup for 4 weeks. Immune function was measured by assessing mitogen-induced lymphocyte proliferation, delayed type hypersensitivity (DTH), neutrophil burst and incidence of infection prior to supplementation (baseline), 4 weeks post supplementation and after a washout period (10 weeks post-supplementation). Nutritional status was also assessed at baseline, week 4, and week 10. Interactions between general nutritional status and immune function were identified. Data was analyzed using multivariate methods. Findings: Supplemental arginine significantly increased plasma arginine and ornithine levels and was orally and metabolically tolerated with no clinically relevant changes in electrolyte levels among groups. Arginine supplementation significantly enhanced lymphocyte proliferation to mitogens by week ten. DTH and neutrophil burst were not different among supplementation groups. Conclusions: Pharmacologic doses of arginine was well tolerated and enhanced lymphocyte proliferation at ten weeks following a 4 week course in nursing home residents with pressure ulcers. Implications: This study demonstrates that 4 weeks of arginine supplementation enhances immune function and recommends its use. Further research needs to be completed investigating the effect of arginine supplementation on wound healing in this population.
Repository Posting Date:
26-Oct-2011
Date of Publication:
22-Jul-2004
Sponsors:
Sigma Theta Tau International

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleArginine Supplementation Enhances Mitogen-Induced Lymphocyte Proliferation in Elderly Nursing Home Residents With Pressure Ulcersen_GB
dc.identifier.urihttp://hdl.handle.net/10755/156724-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Arginine Supplementation Enhances Mitogen-Induced Lymphocyte Proliferation in Elderly Nursing Home Residents With Pressure Ulcers</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Sigma Theta Tau International</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-conference-date"><td class="label">Conference Date:</td><td class="value">July 22-24, 2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Stechmiller, Joyce, ARNP, PhD, CS</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Florida College of Nursing</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Associate Professor</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">stechjk@nursing.ufl.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Bobbi Langkamp-Henken, PhD, RD</td></tr><tr><td colspan="2" class="item-abstract">Arginine supplementation enhances mitogen-induced lymphoctye proliferation in elderly nursing home residents with pressure ulcers Immune function, nutrition, wound healing Objective: The purpose of this study was to determine the effect of arginine supplementation on in vivo and in vitro immune parameters in nursing home elders with pressure ulcers. Design: Experimental double blind controlled randomized study. Population, Sample, Setting, Years: Twenty six nursing home residents (&gt; 65 years of age) with one or more pressure ulcers were randomized to one of two groups from 2001-2003. Methods: One group received 8.5 g of supplemental arginine and the other group received an isonitrogenous amount of a standard protein powder mixed in cherry syrup for 4 weeks. Immune function was measured by assessing mitogen-induced lymphocyte proliferation, delayed type hypersensitivity (DTH), neutrophil burst and incidence of infection prior to supplementation (baseline), 4 weeks post supplementation and after a washout period (10 weeks post-supplementation). Nutritional status was also assessed at baseline, week 4, and week 10. Interactions between general nutritional status and immune function were identified. Data was analyzed using multivariate methods. Findings: Supplemental arginine significantly increased plasma arginine and ornithine levels and was orally and metabolically tolerated with no clinically relevant changes in electrolyte levels among groups. Arginine supplementation significantly enhanced lymphocyte proliferation to mitogens by week ten. DTH and neutrophil burst were not different among supplementation groups. Conclusions: Pharmacologic doses of arginine was well tolerated and enhanced lymphocyte proliferation at ten weeks following a 4 week course in nursing home residents with pressure ulcers. Implications: This study demonstrates that 4 weeks of arginine supplementation enhances immune function and recommends its use. Further research needs to be completed investigating the effect of arginine supplementation on wound healing in this population.</td></tr></table>en_GB
dc.date.available2011-10-26T15:04:16Z-
dc.date.issued2004-07-22en_GB
dc.date.accessioned2011-10-26T15:04:16Z-
dc.description.sponsorshipSigma Theta Tau Internationalen_GB
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