TURMERIC PROTECTS THE BRAIN AFTER STROKE BY BLOCKING INTRAVASCULAR INFLAMMATION

2.50
Hdl Handle:
http://hdl.handle.net/10755/157340
Type:
Presentation
Title:
TURMERIC PROTECTS THE BRAIN AFTER STROKE BY BLOCKING INTRAVASCULAR INFLAMMATION
Abstract:
TURMERIC PROTECTS THE BRAIN AFTER STROKE BY BLOCKING INTRAVASCULAR INFLAMMATION
Conference Sponsor:Western Institute of Nursing
Conference Year:2010
Author:Ritter, Leslie S., PhD, RN
P.I. Institution Name:University of Arizona
Title:Associate Professor
Contact Address:1305 N. Martin, PO Box 210203, Tucson, AZ, 85721, USA
Turmeric is a natural product with known protective anti-inflammatory properties, but its effects on neutrophil-endothelial cell interactions after stroke has not been reported. The purpose of this study was to determine if turmeric inhibits neutrophil-endothelial activation and subsequent cell interactions during reperfusion after ischemic stroke. Male Sprague-Dawley rats (275-325g) underwent 2 hours of ischemic stroke and reperfusion via the filament method and were treated with either 300 mg/kg ip turmeric (95% curcumionoids) or vehicle one hour before reperfusion. Neutrophil adhesion to the cerebral microcirculation, neutrophil oxidant production, mRNA expression of inflammatory endothelial proteins, and infarction size and edema were quantified (N=2-3 per group). Turmeric treatment significantly inhibited neutrophil adhesion, neutrophil production of reactive oxygen species, infarction size and edema (P<0.05), and reduced endothelial cell E-selectin, GRO/CK, and ICAM-1 mRNA expression. These findings report for the first time that the protective effects of acute turmeric treatment for stroke are due in part to inhibition of neutrophil-endothelial cell interactions. (Arizona Biomedical Research Commission).
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Western Institute of Nursing

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleTURMERIC PROTECTS THE BRAIN AFTER STROKE BY BLOCKING INTRAVASCULAR INFLAMMATIONen_GB
dc.identifier.urihttp://hdl.handle.net/10755/157340-
dc.description.abstract<table><tr><td colspan="2" class="item-title">TURMERIC PROTECTS THE BRAIN AFTER STROKE BY BLOCKING INTRAVASCULAR INFLAMMATION</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Western Institute of Nursing</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2010</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Ritter, Leslie S., PhD, RN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Arizona</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Associate Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">1305 N. Martin, PO Box 210203, Tucson, AZ, 85721, USA</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">lritter@nursing.arizona.edu</td></tr><tr><td colspan="2" class="item-abstract">Turmeric is a natural product with known protective anti-inflammatory properties, but its effects on neutrophil-endothelial cell interactions after stroke has not been reported. The purpose of this study was to determine if turmeric inhibits neutrophil-endothelial activation and subsequent cell interactions during reperfusion after ischemic stroke. Male Sprague-Dawley rats (275-325g) underwent 2 hours of ischemic stroke and reperfusion via the filament method and were treated with either 300 mg/kg ip turmeric (95% curcumionoids) or vehicle one hour before reperfusion. Neutrophil adhesion to the cerebral microcirculation, neutrophil oxidant production, mRNA expression of inflammatory endothelial proteins, and infarction size and edema were quantified (N=2-3 per group). Turmeric treatment significantly inhibited neutrophil adhesion, neutrophil production of reactive oxygen species, infarction size and edema (P&lt;0.05), and reduced endothelial cell E-selectin, GRO/CK, and ICAM-1 mRNA expression. These findings report for the first time that the protective effects of acute turmeric treatment for stroke are due in part to inhibition of neutrophil-endothelial cell interactions. (Arizona Biomedical Research Commission).</td></tr></table>en_GB
dc.date.available2011-10-26T19:47:01Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T19:47:01Z-
dc.description.sponsorshipWestern Institute of Nursingen_GB
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