AMPLITUDE INTEGRATED EEG: A NOVEL PHYSIOLOGIC MEASURE OF PRETERM INFANT BRAIN FUNCTION

2.50
Hdl Handle:
http://hdl.handle.net/10755/157378
Type:
Presentation
Title:
AMPLITUDE INTEGRATED EEG: A NOVEL PHYSIOLOGIC MEASURE OF PRETERM INFANT BRAIN FUNCTION
Abstract:
AMPLITUDE INTEGRATED EEG: A NOVEL PHYSIOLOGIC MEASURE OF PRETERM INFANT BRAIN FUNCTION
Conference Sponsor:Western Institute of Nursing
Conference Year:2010
Author:Thorngate, Lauren, Ph(c), RN, CCRN
P.I. Institution Name:University of Washington School of Nursing and UW Medical Center
Title:Predoctoral Fellow and Clinical Nurse Specialist
Contact Address:1959 NE Pacific Street, Box 356077, Seattle, WA, 98195, USA
Co-Authors:Shuyuann Wang Foreman; Karen Thomas
PURPOSES/AIMS: Establish feasibility of amplitude integrated EEG (aEEG) as a non-invasive measure of premature infant brain function. Evaluate reliability of published quantitative scoring system (Burdjalov, 2003) and individual items including continuity of background, presence of cycling, amplitude lower margin (¦V), and bandwidth span (peak to trough), combined with lower border amplitude (¦V).
BACKGROUND:
aEEG is a non-invasive technology designed in the 1960s to evaluate brain function after resuscitation in hospitalized adults. The electrical signal (raw EEG) from a single channel via three scalp electrodes undergoes filtering, rectifying, smoothing, and compression onto a semi-logarithmic scale. A bedside monitor displays or downloads the data as a trended pattern. Baseline voltage and continuity of background represent a global picture of brain function rather than identifying particular waves or hemispheric activity. Continuous impedance readings and raw EEG waves reduce artifactual interpretation and enhance signal fidelity. Extensive experience in Europe has demonstrated utility as a clinical tool for monitoring premature infant brain maturation and injury. In the U.S., the clinical and research applications have primarily been limited to term infants suffering hypoxic ischemic injury. The device is FDA approved and commercially available.
METHODS:
This abstract represents the proposed work of two studies utilizing the Cerebral Function Monitor {CFM 6000}, (Olympic Medical, a Natus Company, San Carlos, CA) to measure patterns of brain function among premature infants. The first study will establish feasibility, the second will utilize a within subject design to explore patterns of brain function before and after exposure to opioids administered for persistent pain. Each study anticipates a sample of 15 premature infants (28-33 weeks gestation at birth and 26-32 weeks postmenstrual age respectively). After implementation of a standardized protocol for skin preparation, hydrogel electrodes will be applied to the biparietal (P3-P4) sites by premature head size template with International 10-20 placement. The same scoring tool will be applied to all data with inter and intra-rater reliability assessed for each subject. The length of recording for the feasibility study is approximately 3 hours, with a longer recording projected for the opioid study up to 24 hours. The setting for both studies is a 36 bed Level III NICU, in a tertiary academic medical center located in the Pacific Northwest. The analytic plan includes descriptive statistics with data management using the most current version of SPSS. A demographic and clinical profile of the sample will be developed with respect to all study variables.
RESULTS:
The studies are in progress. At the time of submission, the feasibility study has enrolled the first infant; the second study is currently under IRB review with enrollment projected for late 2009.
IMPLICATIONS:
Amplitude integrated EEG could provide the data upon which to build future research of premature infant responses to nursing care. Longer-term outcomes could inform optimal treatment of pain and ultimately promote neuroprotection and improved brain function in the developing human.
Burdjalov, V.F., Baumgart, S., & Spitzer, A.R. (2003). Cerebral function monitoring: A new scoring system for the evaluation of brain maturation in neonates. Pediatrics, 112, 855-861.

Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Western Institute of Nursing

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleAMPLITUDE INTEGRATED EEG: A NOVEL PHYSIOLOGIC MEASURE OF PRETERM INFANT BRAIN FUNCTIONen_GB
dc.identifier.urihttp://hdl.handle.net/10755/157378-
dc.description.abstract<table><tr><td colspan="2" class="item-title">AMPLITUDE INTEGRATED EEG: A NOVEL PHYSIOLOGIC MEASURE OF PRETERM INFANT BRAIN FUNCTION</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Western Institute of Nursing</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2010</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Thorngate, Lauren, Ph(c), RN, CCRN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Washington School of Nursing and UW Medical Center</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Predoctoral Fellow and Clinical Nurse Specialist</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">1959 NE Pacific Street, Box 356077, Seattle, WA, 98195, USA</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">laurent3@uw.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Shuyuann Wang Foreman; Karen Thomas</td></tr><tr><td colspan="2" class="item-abstract">PURPOSES/AIMS: Establish feasibility of amplitude integrated EEG (aEEG) as a non-invasive measure of premature infant brain function. Evaluate reliability of published quantitative scoring system (Burdjalov, 2003) and individual items including continuity of background, presence of cycling, amplitude lower margin (&brvbar;V), and bandwidth span (peak to trough), combined with lower border amplitude (&brvbar;V).<br/> BACKGROUND:<br/>aEEG is a non-invasive technology designed in the 1960s to evaluate brain function after resuscitation in hospitalized adults. The electrical signal (raw EEG) from a single channel via three scalp electrodes undergoes filtering, rectifying, smoothing, and compression onto a semi-logarithmic scale. A bedside monitor displays or downloads the data as a trended pattern. Baseline voltage and continuity of background represent a global picture of brain function rather than identifying particular waves or hemispheric activity. Continuous impedance readings and raw EEG waves reduce artifactual interpretation and enhance signal fidelity. Extensive experience in Europe has demonstrated utility as a clinical tool for monitoring premature infant brain maturation and injury. In the U.S., the clinical and research applications have primarily been limited to term infants suffering hypoxic ischemic injury. The device is FDA approved and commercially available. <br/> METHODS:<br/>This abstract represents the proposed work of two studies utilizing the Cerebral Function Monitor {CFM 6000}, (Olympic Medical, a Natus Company, San Carlos, CA) to measure patterns of brain function among premature infants. The first study will establish feasibility, the second will utilize a within subject design to explore patterns of brain function before and after exposure to opioids administered for persistent pain. Each study anticipates a sample of 15 premature infants (28-33 weeks gestation at birth and 26-32 weeks postmenstrual age respectively). After implementation of a standardized protocol for skin preparation, hydrogel electrodes will be applied to the biparietal (P3-P4) sites by premature head size template with International 10-20 placement. The same scoring tool will be applied to all data with inter and intra-rater reliability assessed for each subject. The length of recording for the feasibility study is approximately 3 hours, with a longer recording projected for the opioid study up to 24 hours. The setting for both studies is a 36 bed Level III NICU, in a tertiary academic medical center located in the Pacific Northwest. The analytic plan includes descriptive statistics with data management using the most current version of SPSS. A demographic and clinical profile of the sample will be developed with respect to all study variables. <br/> RESULTS:<br/>The studies are in progress. At the time of submission, the feasibility study has enrolled the first infant; the second study is currently under IRB review with enrollment projected for late 2009. <br/> IMPLICATIONS:<br/>Amplitude integrated EEG could provide the data upon which to build future research of premature infant responses to nursing care. Longer-term outcomes could inform optimal treatment of pain and ultimately promote neuroprotection and improved brain function in the developing human.<br/>Burdjalov, V.F., Baumgart, S., &amp; Spitzer, A.R. (2003). Cerebral function monitoring: A new scoring system for the evaluation of brain maturation in neonates. Pediatrics, 112, 855-861.<br/> <br/></td></tr></table>en_GB
dc.date.available2011-10-26T19:49:06Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T19:49:06Z-
dc.description.sponsorshipWestern Institute of Nursingen_GB
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