2.50
Hdl Handle:
http://hdl.handle.net/10755/157617
Type:
Presentation
Title:
RCT Of the Efficacy of Silver Nanoparticle Gel Against Bacterial Hand Flora
Abstract:
RCT Of the Efficacy of Silver Nanoparticle Gel Against Bacterial Hand Flora
Conference Sponsor:Western Institute of Nursing
Conference Year:2009
Author:Schlicher, Michael, PhD, RN, CNS
P.I. Institution Name:U.S. Army
Title:Research Scientist
Contact Address:3851 Roger Brooke Drive, Ft. Sam Houston, TX, 78234, USA
Contact Telephone:210-916-3842
Problem:  The hands of healthcare workers (HCWs) are the leading cause of healthcare associated infections (HAIs) in the United States. Effective hand hygiene has been identified as the most important measure to prevent the transmission of microorganisms from the hands of HCWs and reduce HAIs. Alcohol hand gels have been recommended; however, limitations remain such as lack of persistent antimicrobial protection. Silver nanoparticles may offer an alternative; however, the immediate and persistent antibacterial efficacy of silver nanoparticles and user acceptability of nanosilver hand gel was unknown. Aims:  The aim of this study was to test the efficacy of a novel silver nanoparticle gel compared to an alcohol-based hand gel on both immediate and persistent antimicrobial activity obtained from artificially seeded hands. A comparison of user acceptability of the test gels was also sought. Design:  A randomized, controlled, double blinded, design was used to compare the efficacy and acceptability of alcohol gel versus silver nanoparticle gel in adult volunteers. Methods: The study consisted of two phases: a methods development phase and a testing phase. Enrolled subjects began by completing a one-week washout period prior to hand sampling. Baseline bacterial samples were obtained from artificially seeded hands using a modified glove juice technique. For immediate efficacy, hands were seeded, gel was applied for one minute, and samples collected. For persistent efficacy, the gel was applied for 10 minutes followed by artificial seeding and sample collection. Subjects completed a 4 item questionnaire on gel acceptability. Data analysis consisted of paired and unpaired t-tests. Results:  For immediate efficacy, the alcohol hand gel produced greater than or equal to 3.0 log10 reduction in CFUs while the silver nanoparticle gel produced less than or equal to 1.5 log10 reduction. For persistent efficacy, the silver nanoparticle gel produced greater than or equal to 2.0 log10 reduction CFUs, while the alcohol hand gel produced less than or equal to 1.6 log10 reduction. User acceptability was more favorable for the alcohol gel group. Conclusions: Alcohol-based hand gel was most efficacious for immediate bacterial reduction after a one minute application, whereas silver nanoparticle gel was more efficacious for bacterial reduction after a 10 minute persistent exposure. Further investigation is warranted to test silver nanoparticle gel as a persistent antibacterial therapeutic.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Western Institute of Nursing

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleRCT Of the Efficacy of Silver Nanoparticle Gel Against Bacterial Hand Floraen_GB
dc.identifier.urihttp://hdl.handle.net/10755/157617-
dc.description.abstract<table><tr><td colspan="2" class="item-title">RCT Of the Efficacy of Silver Nanoparticle Gel Against Bacterial Hand Flora</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Western Institute of Nursing</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2009</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Schlicher, Michael, PhD, RN, CNS</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">U.S. Army</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Research Scientist</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">3851 Roger Brooke Drive, Ft. Sam Houston, TX, 78234, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">210-916-3842</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">michael.schlicher@amedd.army.mil</td></tr><tr><td colspan="2" class="item-abstract">Problem:&nbsp; The hands of healthcare workers (HCWs) are the leading cause of healthcare associated infections (HAIs) in the United States. Effective hand hygiene has been identified as the most important measure to prevent the transmission of microorganisms from the hands of HCWs and reduce HAIs. Alcohol hand gels have been recommended; however, limitations remain such as lack of persistent antimicrobial protection. Silver nanoparticles may offer an alternative; however, the immediate and persistent antibacterial efficacy of silver nanoparticles and user acceptability of nanosilver hand gel was unknown. Aims:&nbsp; The aim of this study was to test the efficacy of a novel silver nanoparticle gel compared to an alcohol-based hand gel on both immediate and persistent antimicrobial activity obtained from artificially seeded hands. A comparison of user acceptability of the test gels was also sought. Design: &nbsp;A randomized, controlled, double blinded, design was used to compare the efficacy and acceptability of alcohol gel versus silver nanoparticle gel in adult volunteers. Methods: The study consisted of two phases: a methods development phase and a testing phase. Enrolled subjects began by completing a one-week washout period prior to hand sampling. Baseline bacterial samples were obtained from artificially seeded hands using a modified glove juice technique. For immediate efficacy, hands were seeded, gel was applied for one minute, and samples collected. For persistent efficacy, the gel was applied for 10 minutes followed by artificial seeding and sample collection. Subjects completed a 4 item questionnaire on gel acceptability. Data analysis consisted of paired and unpaired t-tests. Results:&nbsp; For immediate efficacy, the alcohol hand gel produced greater than or equal to 3.0 log10 reduction in CFUs while the silver nanoparticle gel produced less than or equal to 1.5 log10 reduction. For persistent efficacy, the silver nanoparticle gel produced greater than or equal to 2.0 log10 reduction CFUs, while the alcohol hand gel produced less than or equal to 1.6 log10 reduction. User acceptability was more favorable for the alcohol gel group. Conclusions: Alcohol-based hand gel was most efficacious for immediate bacterial reduction after a one minute application, whereas silver nanoparticle gel was more efficacious for bacterial reduction after a 10 minute persistent exposure. Further investigation is warranted to test silver nanoparticle gel as a persistent antibacterial therapeutic.</td></tr></table>en_GB
dc.date.available2011-10-26T20:02:30Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T20:02:30Z-
dc.description.sponsorshipWestern Institute of Nursingen_GB
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