2.50
Hdl Handle:
http://hdl.handle.net/10755/158080
Type:
Presentation
Title:
Maximizing Exercise Effectiveness in Fibromyalgia
Abstract:
Maximizing Exercise Effectiveness in Fibromyalgia
Conference Sponsor:Western Institute of Nursing
Conference Year:2004
Author:Dupree Jones, Kim, PhD, RN, FNP
P.I. Institution Name:Oregon Health & Sciences University School of Nursing
Contact Address:, Portland, OR, USA
Co-Authors:Robert Bennett, MD, FRCP; Carol Burckhardt, PhD, RN, PMHMP; Atul Deodhar, MD; Nancy Perrin, PhD
Fibromyalgia (FM) is a common, costly and debilitating chronic pain syndrome diagnosed in nearly 10 million Americans, 90% of whom are women. By definition, people with FM have chronic widespread pain and specified tender point areas. Other symptoms include disrupted sleep, fatigue, decreased cognition, post-exertional exercise pain, and exercise intolerance. Additionally, people with FM report difficulty performing personal care activities, depression and anxiety, and disruption in their family and social lives. All of these factors combine to produce a formidable impact on their quality of life and a clear obligation on the part of health care researchers to respond to their need for symptom management. The majority of people with FM are known to be aerobically unfit, have poor muscle strength and limited flexibility. Deconditioned muscle is theoretically more prone to muscle microtrauma, which causes localized pain and triggers widespread pain through disordered central nervous system processing (i.e., central sensitization). A negative cycle of deconditioning occurs in FM in large part due to exercise-induced pain that limits exercise tolerance. Dysfunctions in multiple hormonal channels may contribute to exercise induced pain, due to their critical role in muscle homeostasis and repair following exercise. The current study tests the effects of an exercise training program on participants whose insulin-like growth factor axis (IGF-1) have been pharmacologically manipulated with pyridostigmine bromide. To fully investigate the effects of exercise training and pyridostigmine bromide, a 2x2x2 (exercise x drug x time) design is being used. We are testing the effects of the exercise and drug independent variables, alone and in combination, on the primary outcome measures of 1) pain and 2) FM-associated symptoms and quality of life. We propose that these symptom outcomes are mediated by changes in the IGF-1 axis. We will provide anecdotal experiences related to study start up and preliminary data profiling the sample.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Western Institute of Nursing

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleMaximizing Exercise Effectiveness in Fibromyalgiaen_GB
dc.identifier.urihttp://hdl.handle.net/10755/158080-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Maximizing Exercise Effectiveness in Fibromyalgia </td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Western Institute of Nursing</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Dupree Jones, Kim, PhD, RN, FNP</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Oregon Health &amp; Sciences University School of Nursing</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">, Portland, OR, USA</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Robert Bennett, MD, FRCP; Carol Burckhardt, PhD, RN, PMHMP; Atul Deodhar, MD; Nancy Perrin, PhD </td></tr><tr><td colspan="2" class="item-abstract">Fibromyalgia (FM) is a common, costly and debilitating chronic pain syndrome diagnosed in nearly 10 million Americans, 90% of whom are women. By definition, people with FM have chronic widespread pain and specified tender point areas. Other symptoms include disrupted sleep, fatigue, decreased cognition, post-exertional exercise pain, and exercise intolerance. Additionally, people with FM report difficulty performing personal care activities, depression and anxiety, and disruption in their family and social lives. All of these factors combine to produce a formidable impact on their quality of life and a clear obligation on the part of health care researchers to respond to their need for symptom management. The majority of people with FM are known to be aerobically unfit, have poor muscle strength and limited flexibility. Deconditioned muscle is theoretically more prone to muscle microtrauma, which causes localized pain and triggers widespread pain through disordered central nervous system processing (i.e., central sensitization). A negative cycle of deconditioning occurs in FM in large part due to exercise-induced pain that limits exercise tolerance. Dysfunctions in multiple hormonal channels may contribute to exercise induced pain, due to their critical role in muscle homeostasis and repair following exercise. The current study tests the effects of an exercise training program on participants whose insulin-like growth factor axis (IGF-1) have been pharmacologically manipulated with pyridostigmine bromide. To fully investigate the effects of exercise training and pyridostigmine bromide, a 2x2x2 (exercise x drug x time) design is being used. We are testing the effects of the exercise and drug independent variables, alone and in combination, on the primary outcome measures of 1) pain and 2) FM-associated symptoms and quality of life. We propose that these symptom outcomes are mediated by changes in the IGF-1 axis. We will provide anecdotal experiences related to study start up and preliminary data profiling the sample. </td></tr></table>en_GB
dc.date.available2011-10-26T20:29:20Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T20:29:20Z-
dc.description.sponsorshipWestern Institute of Nursingen_GB
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