Patterns of Muscle Strength, Fatigue and Body Composition in Women Undergoing Chemotherapy for Breast Cancer

2.50
Hdl Handle:
http://hdl.handle.net/10755/158547
Type:
Presentation
Title:
Patterns of Muscle Strength, Fatigue and Body Composition in Women Undergoing Chemotherapy for Breast Cancer
Abstract:
Patterns of Muscle Strength, Fatigue and Body Composition in Women Undergoing Chemotherapy for Breast Cancer
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2007
Author:Visovsky, Constance, PhD
P.I. Institution Name:University of Nebraska Medical Center
Contact Address:College of Nursing, 985330 Nebraska Medical Center, Omaha, NE, 68198-5330, USA
Treatments for cancer with chemotherapy can have adverse effects on skeletal muscle, and induce side effects such as muscle weakness, fatigue and alterations in body mass. These effects have a decided impact on physical functioning, a particular concern as chemotherapy treatment schedules for breast cancer have become dose-intensive. The purpose of this study is to determine the patterns of body composition (weight, body mass index (BMI), lean body mass (LBM), muscle strength and fatigue in women undergoing chemotherapy for breast cancer. In this prospective longitudinal study a sample of 36 women were followed during their 12 week chemotherapy treatment. Measures of body composition were taken using bioelectrical impedance, muscle strength was quantified using a hand-held dynamometer and fatigue was measured by the Piper Fatigue Scale at baseline, 4, 8, 12 weeks of chemotherapy. Patterns of body composition variables, upper and lower extremity muscle strength and fatigue were examined over time. Mean weight at baseline was 178 lbs. (SD = 47; range=111-309), mean BMI 29.3 (SD 7.8; range=19.4-49.2) and mean LBM 28.8 (SD 4.5; range 23-41). Over time, participants lost an average of 9 lbs. and BMI declined to 28, but LBM remained unchanged. Baseline mean upper extremity muscle strength was 41.8 kg. declining to 36.7 kg. Mean lower extremity muscle strength was 79 kg. at baseline, declining to 70.1 kg. following the first cycle of chemotherapy. Fatigue levels in the behavioral/severity (47% increase), affective meaning (57% increase), and cognitive/mood (14% increase) were the dimensions most affected by chemotherapy. Mean weight and BMI were above recommended levels prior to the start of chemotherapy. Despite initial weight loss, BMI remained above recommended levels, and women failed to gain LBM. Declining muscle strength can impact physical functioning during the treatment phase. Increasing fatigue levels can result in inactivity and exert an additive effect on already weakened muscles, increasing the risk of muscle atrophy. Interventions that can increase LBM, reduce fatigue and maintain muscle strength during cancer treatment are needed to assist in alleviating these deleterious effects.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titlePatterns of Muscle Strength, Fatigue and Body Composition in Women Undergoing Chemotherapy for Breast Canceren_GB
dc.identifier.urihttp://hdl.handle.net/10755/158547-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Patterns of Muscle Strength, Fatigue and Body Composition in Women Undergoing Chemotherapy for Breast Cancer</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2007</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Visovsky, Constance, PhD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Nebraska Medical Center</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">College of Nursing, 985330 Nebraska Medical Center, Omaha, NE, 68198-5330, USA</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">cvisovsky@unmc.edu</td></tr><tr><td colspan="2" class="item-abstract">Treatments for cancer with chemotherapy can have adverse effects on skeletal muscle, and induce side effects such as muscle weakness, fatigue and alterations in body mass. These effects have a decided impact on physical functioning, a particular concern as chemotherapy treatment schedules for breast cancer have become dose-intensive. The purpose of this study is to determine the patterns of body composition (weight, body mass index (BMI), lean body mass (LBM), muscle strength and fatigue in women undergoing chemotherapy for breast cancer. In this prospective longitudinal study a sample of 36 women were followed during their 12 week chemotherapy treatment. Measures of body composition were taken using bioelectrical impedance, muscle strength was quantified using a hand-held dynamometer and fatigue was measured by the Piper Fatigue Scale at baseline, 4, 8, 12 weeks of chemotherapy. Patterns of body composition variables, upper and lower extremity muscle strength and fatigue were examined over time. Mean weight at baseline was 178 lbs. (SD = 47; range=111-309), mean BMI 29.3 (SD 7.8; range=19.4-49.2) and mean LBM 28.8 (SD 4.5; range 23-41). Over time, participants lost an average of 9 lbs. and BMI declined to 28, but LBM remained unchanged. Baseline mean upper extremity muscle strength was 41.8 kg. declining to 36.7 kg. Mean lower extremity muscle strength was 79 kg. at baseline, declining to 70.1 kg. following the first cycle of chemotherapy. Fatigue levels in the behavioral/severity (47% increase), affective meaning (57% increase), and cognitive/mood (14% increase) were the dimensions most affected by chemotherapy. Mean weight and BMI were above recommended levels prior to the start of chemotherapy. Despite initial weight loss, BMI remained above recommended levels, and women failed to gain LBM. Declining muscle strength can impact physical functioning during the treatment phase. Increasing fatigue levels can result in inactivity and exert an additive effect on already weakened muscles, increasing the risk of muscle atrophy. Interventions that can increase LBM, reduce fatigue and maintain muscle strength during cancer treatment are needed to assist in alleviating these deleterious effects.</td></tr></table>en_GB
dc.date.available2011-10-26T21:09:53Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T21:09:53Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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