2.50
Hdl Handle:
http://hdl.handle.net/10755/158598
Type:
Presentation
Title:
Indomethacin Reduces Muscle Wasting in Tumor-Bearing Mice
Abstract:
Indomethacin Reduces Muscle Wasting in Tumor-Bearing Mice
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2002
Author:Al-Majid, Sadeeka,
P.I. Institution Name:Virginia Commonwealth University
Title:Assistant Professor
Contact Address:School of Nursing, 1220 East Broad Street, PO Box 980567, Richmond, VA, 23298-0567, USA
Contact Telephone:804.828.3447
Cancer cachexia is a syndrome of progressive weight loss and skeletal muscle wasting that impacts negatively on quality of life and survival in persons with progressive tumor growth. One theory is that tumor growth stimulates the production of proinflammatory cytokines, several of which cause muscle protein degradation when injected into healthy animals. Prostaglandins (PG) also induce proteolysis and inhibitors of PG synthesis have been shown to preserve body weight and prolong survival in animal models of cancer cachexia. The purpose of this study was to determine if administration of an inhibitor of PG synthesis, such as indomethacin (indo) or ibuprofen (ibu), would preserve muscle mass in tumor bearing (tb) mice. In experiment 1, 20 mice were inoculated with the colon-26 adenocarcinoma cell line and 16 served as healthy controls. One half of each group was given .02% indo (w/v) in their drinking water. In experiment 2, one half the tb and control groups were given .02% ibu in their drinking water. After 21 days of tumor growth, we compared body weight, and weight of the gastrocnemius (gastroc) muscle in tb and healthy control animals given plain water or water with indo or ibu. Data were analyzed using ANOVA and the Duncan post hoc test of group differences. Body weight and gastroc weight of the tb mice were significantly less than controls, and body weight and gastroc weight of the tb mice given indo were significantly greater than tb mice given plain water. Similar data were obtained in experiment 2 using ibu. These data suggest that muscle wasting is a significant component of weight loss seen with cancer cachexia, and muscle wasting is mediated in part by PG. The effects of PG inhibitors on body weight and muscle mass should be examined in cancer patients.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleIndomethacin Reduces Muscle Wasting in Tumor-Bearing Miceen_GB
dc.identifier.urihttp://hdl.handle.net/10755/158598-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Indomethacin Reduces Muscle Wasting in Tumor-Bearing Mice</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2002</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Al-Majid, Sadeeka, </td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Virginia Commonwealth University</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">School of Nursing, 1220 East Broad Street, PO Box 980567, Richmond, VA, 23298-0567, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">804.828.3447</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">salmaji1@vcu.edu</td></tr><tr><td colspan="2" class="item-abstract">Cancer cachexia is a syndrome of progressive weight loss and skeletal muscle wasting that impacts negatively on quality of life and survival in persons with progressive tumor growth. One theory is that tumor growth stimulates the production of proinflammatory cytokines, several of which cause muscle protein degradation when injected into healthy animals. Prostaglandins (PG) also induce proteolysis and inhibitors of PG synthesis have been shown to preserve body weight and prolong survival in animal models of cancer cachexia. The purpose of this study was to determine if administration of an inhibitor of PG synthesis, such as indomethacin (indo) or ibuprofen (ibu), would preserve muscle mass in tumor bearing (tb) mice. In experiment 1, 20 mice were inoculated with the colon-26 adenocarcinoma cell line and 16 served as healthy controls. One half of each group was given .02% indo (w/v) in their drinking water. In experiment 2, one half the tb and control groups were given .02% ibu in their drinking water. After 21 days of tumor growth, we compared body weight, and weight of the gastrocnemius (gastroc) muscle in tb and healthy control animals given plain water or water with indo or ibu. Data were analyzed using ANOVA and the Duncan post hoc test of group differences. Body weight and gastroc weight of the tb mice were significantly less than controls, and body weight and gastroc weight of the tb mice given indo were significantly greater than tb mice given plain water. Similar data were obtained in experiment 2 using ibu. These data suggest that muscle wasting is a significant component of weight loss seen with cancer cachexia, and muscle wasting is mediated in part by PG. The effects of PG inhibitors on body weight and muscle mass should be examined in cancer patients.</td></tr></table>en_GB
dc.date.available2011-10-26T21:12:47Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T21:12:47Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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