C-fibers mediate hyperalgesia from lateral hypothalamus stimulation through alpha1-adrenoceptors in the dorsal horn.

2.50
Hdl Handle:
http://hdl.handle.net/10755/158683
Type:
Presentation
Title:
C-fibers mediate hyperalgesia from lateral hypothalamus stimulation through alpha1-adrenoceptors in the dorsal horn.
Abstract:
C-fibers mediate hyperalgesia from lateral hypothalamus stimulation through alpha1-adrenoceptors in the dorsal horn.
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2004
Author:Jeong, Younhee, MSN, RN
Contact Address:Medical Surgical Nursing, 845 S. Damen Ave, Chicago, IL, 60612-7350 , USA
Co-Authors:Janean Holden, RN, PhD, Advisor
Nurses are often the primary care givers for patients in pain. To provide optimal care, nurses need to understand how the body processes and modifies pain. Previous work form our lab has shown that stimulation of the lateral hypothalamus (LH) produces both analgesia and an increased pain response (hyperalgesia) on the foot withdrawal test in rats. This dual response is found in some chronic pain states. In this response, alpha2-adrenoceptors in the spinal cord dorsal horn mediate analgesia while alpha1-adrenocpetors mediate hyperalgesia. Because C-fibers are known to be involved in chronic pain, we microinjected the cholinergic agonist carbachol into the left LH (125 nmol/0.05 ml) in female Sprague-Dawley rats (259-308 g) and tested whether analgesia occurred on the foot withdrawal test using a heating rate that activates C-fibers. Contrary to our earlier findings, analgesia did not occur. However, when we gave the intrathecal alpha1-adrenoceptor antagonist WB4101 (97nmol) following LH stimulation, analgesia occurred as compared to control animals (15.64 ± 1.04 vs. 11.63 ± 0.19 sec, p<0.05), and no significant differences between the left and right paw were found (p > 0.05). These data suggest that C-fibers mediate hyperalgesia from LH stimulation through alpha1-adrenoceptors in the dorsal horn and may contribute to chronic pain states.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleC-fibers mediate hyperalgesia from lateral hypothalamus stimulation through alpha1-adrenoceptors in the dorsal horn.en_GB
dc.identifier.urihttp://hdl.handle.net/10755/158683-
dc.description.abstract<table><tr><td colspan="2" class="item-title">C-fibers mediate hyperalgesia from lateral hypothalamus stimulation through alpha1-adrenoceptors in the dorsal horn.</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Jeong, Younhee, MSN, RN</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Medical Surgical Nursing, 845 S. Damen Ave, Chicago, IL, 60612-7350 , USA</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Janean Holden, RN, PhD, Advisor </td></tr><tr><td colspan="2" class="item-abstract">Nurses are often the primary care givers for patients in pain. To provide optimal care, nurses need to understand how the body processes and modifies pain. Previous work form our lab has shown that stimulation of the lateral hypothalamus (LH) produces both analgesia and an increased pain response (hyperalgesia) on the foot withdrawal test in rats. This dual response is found in some chronic pain states. In this response, alpha2-adrenoceptors in the spinal cord dorsal horn mediate analgesia while alpha1-adrenocpetors mediate hyperalgesia. Because C-fibers are known to be involved in chronic pain, we microinjected the cholinergic agonist carbachol into the left LH (125 nmol/0.05 ml) in female Sprague-Dawley rats (259-308 g) and tested whether analgesia occurred on the foot withdrawal test using a heating rate that activates C-fibers. Contrary to our earlier findings, analgesia did not occur. However, when we gave the intrathecal alpha1-adrenoceptor antagonist WB4101 (97nmol) following LH stimulation, analgesia occurred as compared to control animals (15.64 &plusmn; 1.04 vs. 11.63 &plusmn; 0.19 sec, p&lt;0.05), and no significant differences between the left and right paw were found (p &gt; 0.05). These data suggest that C-fibers mediate hyperalgesia from LH stimulation through alpha1-adrenoceptors in the dorsal horn and may contribute to chronic pain states. </td></tr></table>en_GB
dc.date.available2011-10-26T21:17:42Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T21:17:42Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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