2.50
Hdl Handle:
http://hdl.handle.net/10755/158695
Type:
Presentation
Title:
Antioxidant Status in Preterm Infants at Risk for Bronchopulmonary Dysplasia
Abstract:
Antioxidant Status in Preterm Infants at Risk for Bronchopulmonary Dysplasia
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2004
Author:Mentro, Anne, MS, RN, CPNP
Contact Address:1428 King Avenue, Apt. #16, Columbus, OH, 43212, USA
Co-Authors:Deborah Steward, PhD, RN, Assistant Professor
Bronchopulmonary dysplasia (BPD) is a lung disease of prematurity whose pathophysiology is poorly understood. BPD is thought to result from oxidative stress facilitated by decreased antioxidant reserves. It remains unknown how nutrition affects antioxidant status during the initial days of life in extremely preterm infants at risk for BPD. Purpose: This study was designed to explore the relationships among selected antioxidants (retinol, selenium, glutathione peroxidase (GPx)), nutritional intake, and respiratory outcomes during the initial days of life in extremely preterm infants. Subjects and Method: Preterm infants (n=40) less than 30 weeks gestational age receiving surfactant for respiratory distress syndrome are being recruited following admission to two area Neonatal Intensive Care Units. 0.7ml. of whole blood is being collected at 24 hours and 7 days of life and analyzed for plasma retinol and erythrocyte selenium and GPx activity. Nutritional intake and ventilatory parameters are being recorded over the first 28 days. Antioxidant and nutritional variables will be examined for significant relationships at each time point as well as their ability to predict respiratory outcomes at 28 days. Preliminary Results: Nine infants of 24 to 29 weeks gestational age with birth weights of 550 to 1250 grams have been recruited to date. All infants received TPN during the first week of life with vitamin A and selenium contents well below those obtained in utero (mean vitamin A: 736 IU; mean selenium: 0.99 mcg). By 7 days, 5 infants were mechanically ventilated, 2 required CPAP, and 2 required supplemental oxygen. Weights at 7 days for the sample were significantly lower than those obtained at birth (p < .0001), and only 2 infants reached their birth weight at this time.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleAntioxidant Status in Preterm Infants at Risk for Bronchopulmonary Dysplasiaen_GB
dc.identifier.urihttp://hdl.handle.net/10755/158695-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Antioxidant Status in Preterm Infants at Risk for Bronchopulmonary Dysplasia</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Mentro, Anne, MS, RN, CPNP</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">1428 King Avenue, Apt. #16, Columbus, OH, 43212, USA</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Deborah Steward, PhD, RN, Assistant Professor</td></tr><tr><td colspan="2" class="item-abstract">Bronchopulmonary dysplasia (BPD) is a lung disease of prematurity whose pathophysiology is poorly understood. BPD is thought to result from oxidative stress facilitated by decreased antioxidant reserves. It remains unknown how nutrition affects antioxidant status during the initial days of life in extremely preterm infants at risk for BPD. Purpose: This study was designed to explore the relationships among selected antioxidants (retinol, selenium, glutathione peroxidase (GPx)), nutritional intake, and respiratory outcomes during the initial days of life in extremely preterm infants. Subjects and Method: Preterm infants (n=40) less than 30 weeks gestational age receiving surfactant for respiratory distress syndrome are being recruited following admission to two area Neonatal Intensive Care Units. 0.7ml. of whole blood is being collected at 24 hours and 7 days of life and analyzed for plasma retinol and erythrocyte selenium and GPx activity. Nutritional intake and ventilatory parameters are being recorded over the first 28 days. Antioxidant and nutritional variables will be examined for significant relationships at each time point as well as their ability to predict respiratory outcomes at 28 days. Preliminary Results: Nine infants of 24 to 29 weeks gestational age with birth weights of 550 to 1250 grams have been recruited to date. All infants received TPN during the first week of life with vitamin A and selenium contents well below those obtained in utero (mean vitamin A: 736 IU; mean selenium: 0.99 mcg). By 7 days, 5 infants were mechanically ventilated, 2 required CPAP, and 2 required supplemental oxygen. Weights at 7 days for the sample were significantly lower than those obtained at birth (p &lt; .0001), and only 2 infants reached their birth weight at this time.</td></tr></table>en_GB
dc.date.available2011-10-26T21:18:25Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T21:18:25Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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