Measuring Cortisol and Determining Hypothalamic-Pituitary-Adrenal (HPA) Axis Regulation and Dysregulation in People with Dementia

2.50
Hdl Handle:
http://hdl.handle.net/10755/158710
Type:
Presentation
Title:
Measuring Cortisol and Determining Hypothalamic-Pituitary-Adrenal (HPA) Axis Regulation and Dysregulation in People with Dementia
Abstract:
Measuring Cortisol and Determining Hypothalamic-Pituitary-Adrenal (HPA) Axis Regulation and Dysregulation in People with Dementia
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2009
Author:Kovach, Christine, PhD
P.I. Institution Name:University of Wisconsin-Milwaukee
Title:Nursing
Contact Address:1921 East Hartford Avenue, Milwaukee, WI, 53211, USA
Contact Telephone:414-229-6233
Co-Authors:C.R. Kovach, , University of Wisconsin-Milwaukee, Milwaukee, WI; H. Raff, , Medical College of Wisconsin, Milwaukee, WI; D. Woods, , University of California Los Angeles, Los Angeles, CA;
Assessing cortisol levels of people with dementia has the potential to contribute to a better understanding of stress and underlying mechanisms associated with negative outcomes. The purpose of this study was to test the feasibility of saliva collection to measure endogenous cortisol in nursing home residents with advanced dementia and describe alterations in hypothalamic-pituitary-adrenal (HPA) axis function. Eighty three people with an average age of 87.54 (SD=6.74) and average Mini Mental Status Exam Score of 7.3 (SD=6.3) participated. Procedures for collecting samples suitable for assay will be described. Saliva was collected four times throughout the day for each subject. Ninety-three percent (N=616) of the samples were able to be collected and were of sufficient quantity for assay. There were 22 (3%) instances in which subjects refused saliva collection and 24 (4%) instances in which the quantity of saliva obtained was insufficient for assay. An algorithm was developed to differentiate patterns of cortisol response. Analysis of data using this algorithm revealed that 14% (n=11) of the residents showed the normal adult pattern of high morning levels decreasing throughout the day. More than half (54% n=42) demonstrated an increase in the evening cortisol levels, while the remaining profiles were flat (32%, n=25), suggesting Hypothalamic-Pituitary-Adrenal (HPA) dysregulation in this population. These data suggest the feasibility of salivary cortisol collection and analyses to obtain cortisol rhythm in a population of nursing home residents with dementia who are difficult to study. The dysregulated and flattened cortisol profiles may be an indication of sleep disruption increased agitated behavior, or impending acute illness. As such, assaying salivary cottisol and the resulting cortisol profiles may provide insight into identifying and intervening early with those individuals most at risk for developing these clinical conditions.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleMeasuring Cortisol and Determining Hypothalamic-Pituitary-Adrenal (HPA) Axis Regulation and Dysregulation in People with Dementiaen_GB
dc.identifier.urihttp://hdl.handle.net/10755/158710-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Measuring Cortisol and Determining Hypothalamic-Pituitary-Adrenal (HPA) Axis Regulation and Dysregulation in People with Dementia</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2009</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Kovach, Christine, PhD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Wisconsin-Milwaukee</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Nursing</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">1921 East Hartford Avenue, Milwaukee, WI, 53211, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">414-229-6233</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">ckovach@uwm.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">C.R. Kovach, , University of Wisconsin-Milwaukee, Milwaukee, WI; H. Raff, , Medical College of Wisconsin, Milwaukee, WI; D. Woods, , University of California Los Angeles, Los Angeles, CA;</td></tr><tr><td colspan="2" class="item-abstract">Assessing cortisol levels of people with dementia has the potential to contribute to a better understanding of stress and underlying mechanisms associated with negative outcomes. The purpose of this study was to test the feasibility of saliva collection to measure endogenous cortisol in nursing home residents with advanced dementia and describe alterations in hypothalamic-pituitary-adrenal (HPA) axis function. Eighty three people with an average age of 87.54 (SD=6.74) and average Mini Mental Status Exam Score of 7.3 (SD=6.3) participated. Procedures for collecting samples suitable for assay will be described. Saliva was collected four times throughout the day for each subject. Ninety-three percent (N=616) of the samples were able to be collected and were of sufficient quantity for assay. There were 22 (3%) instances in which subjects refused saliva collection and 24 (4%) instances in which the quantity of saliva obtained was insufficient for assay. An algorithm was developed to differentiate patterns of cortisol response. Analysis of data using this algorithm revealed that 14% (n=11) of the residents showed the normal adult pattern of high morning levels decreasing throughout the day. More than half (54% n=42) demonstrated an increase in the evening cortisol levels, while the remaining profiles were flat (32%, n=25), suggesting Hypothalamic-Pituitary-Adrenal (HPA) dysregulation in this population. These data suggest the feasibility of salivary cortisol collection and analyses to obtain cortisol rhythm in a population of nursing home residents with dementia who are difficult to study. The dysregulated and flattened cortisol profiles may be an indication of sleep disruption increased agitated behavior, or impending acute illness. As such, assaying salivary cottisol and the resulting cortisol profiles may provide insight into identifying and intervening early with those individuals most at risk for developing these clinical conditions.</td></tr></table>en_GB
dc.date.available2011-10-26T21:19:16Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T21:19:16Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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