Relationship between Genetic Variants and Pain Response in Children Receiving an Intravenous Catheter

2.50
Hdl Handle:
http://hdl.handle.net/10755/159151
Type:
Presentation
Title:
Relationship between Genetic Variants and Pain Response in Children Receiving an Intravenous Catheter
Abstract:
Relationship between Genetic Variants and Pain Response in Children Receiving an Intravenous Catheter
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2005
Author:Schutte, Debra, PhD, RN
P.I. Institution Name:University of Iowa
Title:Assistant Professor
Contact Address:College of Nursing, 484 Nursing Building, Iowa City, IA, 52242-1121, USA
Contact Telephone:319/384-4700
Co-Authors:Kirsten Hanrahan, MSN, RN, Project Director; Milena Floria-Santos; Ann Marie McCarthy, FAAN, PhD, MSN, RN, Associate Professor; and Charmaine Kleiber, FAAN, PhD, MSN, RN, Associate Professor
Background Children demonstrate variability in response to intravenous
(IV) catheter insertions. Evidence suggests that these differences may be
related, in part, to genetic variation. The identification of genes that
influence children's pain response is needed in order to develop and
prescribe the most appropriate interventions. Purpose The purpose of this study is to examine the relationship between
candidate genes for pain and child response to IV insertions.
Methodology Subjects: One-hundred fifty children (age 4-10 years),
scheduled for an IV insertion prior to a diagnostic procedure, and their
parents were recruited from an outpatient setting. Procedures: All
subjects received a topical analgesic prior to the IV insertion. Cheek
swabs for DNA extraction and subsequent genotyping were collected from the
children and available biological parents. Measures of child response to
the IV insertion included: 1) child self-report measure of pain (OUCHER
Scale), 2) behavioral measure of child distress (OSBD-R), and 3) parent
report of child distress. Results Genotyping, using polymerase chain reaction techniques, is
underway for common sequence variations in three genes hypothesized to
play a role in pain perception and transmission: Mu-opioid receptor,
Catechol-o-methyltransferase, and Proenkephalin. Descriptive statistics
will be used to identify children who are high or low pain responders. The
transmission disequilibrium test, using Chi-squared methodology, will
determine the extent to which the observed transmission ratio of gene
variants from parent to children of high and low pain response phenotypes
differs from the expected 50:50 transmission ratio. Additional group
comparison analyses will be completed to examine the relationship between
genetic variants and other child characteristics on self-reported and
observed child pain and distress. Results from this study will contribute
to our understanding of the genetic basis of pain and distress and to our
ability to more effectively develop and prescribe interventions.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleRelationship between Genetic Variants and Pain Response in Children Receiving an Intravenous Catheteren_GB
dc.identifier.urihttp://hdl.handle.net/10755/159151-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Relationship between Genetic Variants and Pain Response in Children Receiving an Intravenous Catheter</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2005</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Schutte, Debra, PhD, RN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Iowa</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">College of Nursing, 484 Nursing Building, Iowa City, IA, 52242-1121, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">319/384-4700</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">debra-schutte@uiowa.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Kirsten Hanrahan, MSN, RN, Project Director; Milena Floria-Santos; Ann Marie McCarthy, FAAN, PhD, MSN, RN, Associate Professor; and Charmaine Kleiber, FAAN, PhD, MSN, RN, Associate Professor</td></tr><tr><td colspan="2" class="item-abstract">Background Children demonstrate variability in response to intravenous <br/> (IV) catheter insertions. Evidence suggests that these differences may be <br/> related, in part, to genetic variation. The identification of genes that <br/> influence children's pain response is needed in order to develop and <br/> prescribe the most appropriate interventions. Purpose The purpose of this study is to examine the relationship between <br/> candidate genes for pain and child response to IV insertions. <br/> Methodology Subjects: One-hundred fifty children (age 4-10 years), <br/> scheduled for an IV insertion prior to a diagnostic procedure, and their <br/> parents were recruited from an outpatient setting. Procedures: All <br/> subjects received a topical analgesic prior to the IV insertion. Cheek <br/> swabs for DNA extraction and subsequent genotyping were collected from the <br/> children and available biological parents. Measures of child response to <br/> the IV insertion included: 1) child self-report measure of pain (OUCHER <br/> Scale), 2) behavioral measure of child distress (OSBD-R), and 3) parent <br/> report of child distress. Results Genotyping, using polymerase chain reaction techniques, is <br/> underway for common sequence variations in three genes hypothesized to <br/> play a role in pain perception and transmission: Mu-opioid receptor, <br/> Catechol-o-methyltransferase, and Proenkephalin. Descriptive statistics <br/> will be used to identify children who are high or low pain responders. The <br/> transmission disequilibrium test, using Chi-squared methodology, will <br/> determine the extent to which the observed transmission ratio of gene <br/> variants from parent to children of high and low pain response phenotypes <br/> differs from the expected 50:50 transmission ratio. Additional group <br/> comparison analyses will be completed to examine the relationship between <br/> genetic variants and other child characteristics on self-reported and <br/> observed child pain and distress. Results from this study will contribute <br/> to our understanding of the genetic basis of pain and distress and to our <br/> ability to more effectively develop and prescribe interventions.</td></tr></table>en_GB
dc.date.available2011-10-26T21:45:17Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T21:45:17Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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