2.50
Hdl Handle:
http://hdl.handle.net/10755/159418
Type:
Presentation
Title:
Symptom Trajectory in Chemotherapy-Induced Peripheral Neuropathy
Abstract:
Symptom Trajectory in Chemotherapy-Induced Peripheral Neuropathy
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2003
Author:Visovsky, Constance
Contact Address:SON, 326 High Bluff, Aurora, OH, 44202, USA
Purpose: Patients treated for cancer with cytotoxic/neurotoxic drugs experience peripheral neuropathy resulting in alterations in peripheral nerve function and symptom distress. Studies of drug-induced neuropathy have been few, and patients have not been systematically monitored for long-term effects. Thus, associated peripheral neuropathy represents chronic, long-term changes in function for which patients and families are ill prepared. Limited data exist quantifying physiologic changes in nerve function in individuals receiving neurotoxic chemotherapy. The purpose of this prospective, exploratory pilot study was to determine: 1) the change in peripheral nerve function and symptom distress during treatment with chemotherapy; 2) to determine the relationship between the extent of peripheral neuropathy and symptom distress. Theoretical Framework: A physiological framework was used. Subjects: A convenience sample of 16 subjects with cancer receiving chemotherapy had measures of peripheral nerve function measured at baseline, 4 and 12 weeks of treatment. Methods: A prospective, exploratory design was used. Data was analyzed using plots and regression slopes to determine change over time in peripheral nerve function and associated symptom distress. Independent variables were age, gender and cumulative drug dose. Outcome variables were sensation, gait/ balance, vision, hearing, vibratory sense, deep tendon reflexes, blood pressure, and symptom distress. Results: Overall increases in symptom distress, peripheral neuropathy symptoms were experienced. Declines in hearing, cutaneous sensation, vibratory sensation, deep tendon reflexes, and muscle strength were found. Changes in visual acuity, and orthostatic blood pressure were noted from baseline to 12 weeks while gait/balance remained stable. Conclusions: The characterization of peripheral nerve changes can assist in understanding the nature of peripheral neuropathy and aid in developing educational materials to prepare patients for any necessary life-style adjustments. Study findings are essential to foster the development of interventions aimed at preserving functional status and decreasing symptom distress in patients receiving cancer treatment with neurotoxic agents. AN: MN030339
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleSymptom Trajectory in Chemotherapy-Induced Peripheral Neuropathyen_GB
dc.identifier.urihttp://hdl.handle.net/10755/159418-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Symptom Trajectory in Chemotherapy-Induced Peripheral Neuropathy </td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2003</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Visovsky, Constance</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">SON, 326 High Bluff, Aurora, OH, 44202, USA</td></tr><tr><td colspan="2" class="item-abstract">Purpose: Patients treated for cancer with cytotoxic/neurotoxic drugs experience peripheral neuropathy resulting in alterations in peripheral nerve function and symptom distress. Studies of drug-induced neuropathy have been few, and patients have not been systematically monitored for long-term effects. Thus, associated peripheral neuropathy represents chronic, long-term changes in function for which patients and families are ill prepared. Limited data exist quantifying physiologic changes in nerve function in individuals receiving neurotoxic chemotherapy. The purpose of this prospective, exploratory pilot study was to determine: 1) the change in peripheral nerve function and symptom distress during treatment with chemotherapy; 2) to determine the relationship between the extent of peripheral neuropathy and symptom distress. Theoretical Framework: A physiological framework was used. Subjects: A convenience sample of 16 subjects with cancer receiving chemotherapy had measures of peripheral nerve function measured at baseline, 4 and 12 weeks of treatment. Methods: A prospective, exploratory design was used. Data was analyzed using plots and regression slopes to determine change over time in peripheral nerve function and associated symptom distress. Independent variables were age, gender and cumulative drug dose. Outcome variables were sensation, gait/ balance, vision, hearing, vibratory sense, deep tendon reflexes, blood pressure, and symptom distress. Results: Overall increases in symptom distress, peripheral neuropathy symptoms were experienced. Declines in hearing, cutaneous sensation, vibratory sensation, deep tendon reflexes, and muscle strength were found. Changes in visual acuity, and orthostatic blood pressure were noted from baseline to 12 weeks while gait/balance remained stable. Conclusions: The characterization of peripheral nerve changes can assist in understanding the nature of peripheral neuropathy and aid in developing educational materials to prepare patients for any necessary life-style adjustments. Study findings are essential to foster the development of interventions aimed at preserving functional status and decreasing symptom distress in patients receiving cancer treatment with neurotoxic agents. AN: MN030339 </td></tr></table>en_GB
dc.date.available2011-10-26T21:59:46Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T21:59:46Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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