Stimulation of the lateral hypothalamus produces analgesia mediate by pontine noradrenergic neurons

2.50
Hdl Handle:
http://hdl.handle.net/10755/159621
Type:
Presentation
Title:
Stimulation of the lateral hypothalamus produces analgesia mediate by pontine noradrenergic neurons
Abstract:
Stimulation of the lateral hypothalamus produces analgesia mediate by pontine noradrenergic neurons
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2001
Author:Holden, Janean, PhD
P.I. Institution Name:University of Illinois at Chicago
Title:Associate Professor
Contact Address:College of Nursing, 845 South Damen Avenue, M/C 802, 718 NURS, Chicago, IL, 60612, USA
Contact Telephone:312.996.7907
An understanding of endogenous pain modulatory systems may lead to better treatments for pain. Electrical stimulation of the lateral hypothalamus (LH) produces analgesia blocked by intrathecal noradrenergic antagonists, indicating that fibers of passage rather than neurons produce this effect. However, the LH contains substance P-immunoreactive neurons that project to the A7 catecholamine cell group in the pons. A7 neurons innervate the spinal cord dorsal horn and, when activated, produce analgesia blocked by intrathecal noradrenergic antagonists. The excitatory connection between LH and A7 neurons suggests an active role for the LH in this pathway. To investigate LH-induced analgesia, we microinjected 125 nmol/0.05 µl of the cholinergic agonist carbachol into the LH in female Sprague-Dawley rats. Moderate analgesia lasting 25 min was obtained on the tail flick test compared to controls (6.40 ± 0.4 vs. 3.30 ± 0.1 min, p< .05). Following LH stimulation, intrathecal administration of the alpha2-adrenoceptor antagonist yohimbine (194 nmol) produced significant hyperalgesia, while the alpha1 antagonist WB4101 (194 nmol) facilitated analgesia. These findings suggest that LH stimulation activates two distinct pathways mediated by A7 cells that both facilitate and inhibit analgesia.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleStimulation of the lateral hypothalamus produces analgesia mediate by pontine noradrenergic neuronsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/159621-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Stimulation of the lateral hypothalamus produces analgesia mediate by pontine noradrenergic neurons</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2001</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Holden, Janean, PhD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Illinois at Chicago</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Associate Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">College of Nursing, 845 South Damen Avenue, M/C 802, 718 NURS, Chicago, IL, 60612, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">312.996.7907</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">jeholden@uic.edu</td></tr><tr><td colspan="2" class="item-abstract">An understanding of endogenous pain modulatory systems may lead to better treatments for pain. Electrical stimulation of the lateral hypothalamus (LH) produces analgesia blocked by intrathecal noradrenergic antagonists, indicating that fibers of passage rather than neurons produce this effect. However, the LH contains substance P-immunoreactive neurons that project to the A7 catecholamine cell group in the pons. A7 neurons innervate the spinal cord dorsal horn and, when activated, produce analgesia blocked by intrathecal noradrenergic antagonists. The excitatory connection between LH and A7 neurons suggests an active role for the LH in this pathway. To investigate LH-induced analgesia, we microinjected 125 nmol/0.05 &micro;l of the cholinergic agonist carbachol into the LH in female Sprague-Dawley rats. Moderate analgesia lasting 25 min was obtained on the tail flick test compared to controls (6.40 &plusmn; 0.4 vs. 3.30 &plusmn; 0.1 min, p&lt; .05). Following LH stimulation, intrathecal administration of the alpha2-adrenoceptor antagonist yohimbine (194 nmol) produced significant hyperalgesia, while the alpha1 antagonist WB4101 (194 nmol) facilitated analgesia. These findings suggest that LH stimulation activates two distinct pathways mediated by A7 cells that both facilitate and inhibit analgesia.</td></tr></table>en_GB
dc.date.available2011-10-26T22:10:58Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:10:58Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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