2.50
Hdl Handle:
http://hdl.handle.net/10755/159666
Type:
Presentation
Title:
Non-ovarian sources are the major contributors to circulating Activin A in women
Abstract:
Non-ovarian sources are the major contributors to circulating Activin A in women
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2001
Author:Reame, Nancy, PhD
P.I. Institution Name:University of Michigan
Title:Professor
Contact Address:School of Nursing, 400 North Ingalls Building, Rm 2240, Ann Arbor, MI, 48109-0482, USA
Contact Telephone:734.647.0134
From animal studies it appears that activin is a modulator of FSH production and secretion. In addition to the ovary, activin is also produced in other sites. The relative contribution of activin from the ovary to the circulating pool is unclear. To clarify the role of ovarian activin in FSH regulation, we compared concentrations between ovariectomized (OVX, n=5) women receiving ERT to that of normal-cycling (NC, n=10) and perimenopausal (peri, n=21) volunteers. Mean concentrations of plasma gonadal peptides were determined from 4 blood samples drawn across a 24 hr period (follicular phase in cycling women). Gonadal peptides were measured using two-site ELISA immunoassays. The similar concentrations of activin A in women with and without ovaries (OVX, 0.45±0.06; NC, 0.37±0.03; peri, 0.45±0.03 ng/mL) confirms that the bulk of circulating activin A in women is from non-ovarian sources. In contrast, the vitual absence of inhibin B in the OVX group (OVX, assay sensitivity; NC, 58.7±4; peri, 34.0±7 pg/mL) confirms the ovary as the sole source of circulating inhibin B. Moreover, the failure to suppress FSH in the OVX group with estrogen replacement alone (OVX, 40.1±9, NC, 5.5±1, peri, 22.2±5 pg/mL) suggests a primary role for inhibin in the premenopausal rise in FSH.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleNon-ovarian sources are the major contributors to circulating Activin A in womenen_GB
dc.identifier.urihttp://hdl.handle.net/10755/159666-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Non-ovarian sources are the major contributors to circulating Activin A in women</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2001</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Reame, Nancy, PhD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Michigan</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">School of Nursing, 400 North Ingalls Building, Rm 2240, Ann Arbor, MI, 48109-0482, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">734.647.0134</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">nreame@umich.edu</td></tr><tr><td colspan="2" class="item-abstract">From animal studies it appears that activin is a modulator of FSH production and secretion. In addition to the ovary, activin is also produced in other sites. The relative contribution of activin from the ovary to the circulating pool is unclear. To clarify the role of ovarian activin in FSH regulation, we compared concentrations between ovariectomized (OVX, n=5) women receiving ERT to that of normal-cycling (NC, n=10) and perimenopausal (peri, n=21) volunteers. Mean concentrations of plasma gonadal peptides were determined from 4 blood samples drawn across a 24 hr period (follicular phase in cycling women). Gonadal peptides were measured using two-site ELISA immunoassays. The similar concentrations of activin A in women with and without ovaries (OVX, 0.45&plusmn;0.06; NC, 0.37&plusmn;0.03; peri, 0.45&plusmn;0.03 ng/mL) confirms that the bulk of circulating activin A in women is from non-ovarian sources. In contrast, the vitual absence of inhibin B in the OVX group (OVX, assay sensitivity; NC, 58.7&plusmn;4; peri, 34.0&plusmn;7 pg/mL) confirms the ovary as the sole source of circulating inhibin B. Moreover, the failure to suppress FSH in the OVX group with estrogen replacement alone (OVX, 40.1&plusmn;9, NC, 5.5&plusmn;1, peri, 22.2&plusmn;5 pg/mL) suggests a primary role for inhibin in the premenopausal rise in FSH.</td></tr></table>en_GB
dc.date.available2011-10-26T22:13:25Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:13:25Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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