2.50
Hdl Handle:
http://hdl.handle.net/10755/159686
Type:
Presentation
Title:
Characterization of biotherapy induced peripheral neuropathy
Abstract:
Characterization of biotherapy induced peripheral neuropathy
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2001
Author:Visovsky, Constance
P.I. Institution Name:Case Western Reserve University
Contact Address:Frances Payne Bolton School of Nursing, 10900 Euclid Avenue, Cleveland, OH, 44106-4904, USA
Contact Telephone:216.368.5813
Patients treated with neurotoxic drugs experience peripheral neuropathy resulting in alterations in hearing, vision, touch, balance, and blood pressure. This study will determine: 1) changes in peripheral nerve function with biotherapy; 2) individual characteristics pattern in outcome; 3) the relationship between neuropathy and symptom distress; 4) the criterion validity of clinical measures. A physiologic framework of neuronal degeneration is proposed. The independent variables are age, gender and the cumulative dose of biotherapy. Outcome variables are sensation, gait/ balance, vision, hearing, positional blood pressure, and symptom distress. A convenience sample of 65 subjects will be recruited from patients diagnosed with cancer and receiving biologic agents. A prospective, exploratory design is used. Measurements are taken at baseline, 1 and 3 months, and after treatment ends. Hierarchical regression will determine predictors (age, gender)controlling for cumulative drug dose. Multiple regression will examine the relationship between peripheral nerve changes and symptom distress. Pearson's correlation coefficents will determine criterion validity of clinical measures. The characterization of peripheral nerve changes would assist nurses to identify clients at risk of peripheral nerve injury and prepare them for life-style adjustments. Demonstrating the accuracy of clinical measures in monitoring neuropathy is necessary to determine the need for changes in clinical practice.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleCharacterization of biotherapy induced peripheral neuropathyen_GB
dc.identifier.urihttp://hdl.handle.net/10755/159686-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Characterization of biotherapy induced peripheral neuropathy</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2001</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Visovsky, Constance</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Case Western Reserve University</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Frances Payne Bolton School of Nursing, 10900 Euclid Avenue, Cleveland, OH, 44106-4904, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">216.368.5813</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">cxv6@po.cwru.edu</td></tr><tr><td colspan="2" class="item-abstract">Patients treated with neurotoxic drugs experience peripheral neuropathy resulting in alterations in hearing, vision, touch, balance, and blood pressure. This study will determine: 1) changes in peripheral nerve function with biotherapy; 2) individual characteristics pattern in outcome; 3) the relationship between neuropathy and symptom distress; 4) the criterion validity of clinical measures. A physiologic framework of neuronal degeneration is proposed. The independent variables are age, gender and the cumulative dose of biotherapy. Outcome variables are sensation, gait/ balance, vision, hearing, positional blood pressure, and symptom distress. A convenience sample of 65 subjects will be recruited from patients diagnosed with cancer and receiving biologic agents. A prospective, exploratory design is used. Measurements are taken at baseline, 1 and 3 months, and after treatment ends. Hierarchical regression will determine predictors (age, gender)controlling for cumulative drug dose. Multiple regression will examine the relationship between peripheral nerve changes and symptom distress. Pearson's correlation coefficents will determine criterion validity of clinical measures. The characterization of peripheral nerve changes would assist nurses to identify clients at risk of peripheral nerve injury and prepare them for life-style adjustments. Demonstrating the accuracy of clinical measures in monitoring neuropathy is necessary to determine the need for changes in clinical practice.</td></tr></table>en_GB
dc.date.available2011-10-26T22:14:30Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:14:30Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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