Fatigue, Sleep Quality, and Circadian Activity Rhythms during Colon and Rectal Cancer Adjuvant Chemotherapy

2.50
Hdl Handle:
http://hdl.handle.net/10755/159879
Type:
Presentation
Title:
Fatigue, Sleep Quality, and Circadian Activity Rhythms during Colon and Rectal Cancer Adjuvant Chemotherapy
Abstract:
Fatigue, Sleep Quality, and Circadian Activity Rhythms during Colon and Rectal Cancer Adjuvant Chemotherapy
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2010
Author:Berger, Ann, PhD, RN, AOCN, FAAN
P.I. Institution Name:University of Nebraska Medical Center
Contact Address:College of Nursing, 985330 NE MED CENTER, Omaha, NE, 68198-5330, USA
Contact Telephone:402-559-4957
Co-Authors:A.M. Berger, C. Visovsky, H. Marunda, J. Yurkovich, College of Nursing, University of Nebraska Medical Center, Omaha, NE; J.L. Grem, Department of Medicine, University of Nebraska Medical Center, Omaha, NE;
Problem/Purpose: Fatigue is the most frequent and distressing toxicity of colon and rectal cancer chemotherapy (CTX), but few studies have focused on fatigue and its relationship with sleep quality and circadian activity rhythms during adjuvant CTX. This presentation describes patterns of fatigue, sleep quality, and circadian activity rhythms and relationships between variables during the first week of three, 2-week cycles of colon and rectal cancer adjuvant chemotherapy treatment (CTX1-3) and at 6 weeks. Theoretical Framework: Piper's Integrated Fatigue Model proposes fatigue is influenced by activity/rest and sleep/wake patterns. Methods/Design: A longitudinal, descriptive, correlational, design was used for this feasibility study conducted in Midwestern US medical oncology clinics. The sample was 21 participants; most were middle-aged, partnered, employed, with post secondary education. Established measures used were: Piper Fatigue Scale (fatigue), Pittsburgh Sleep Quality Index (sleep quality), wrist actigraphy [circadian activity rhythms: mesor, amplitude, acrophase, circadian quotient, and 24-hr autocorrelation (r24)], and demographic/medical data form. Analysis: Descriptive statistics, RM-ANOVAs and Pearson/Spearman correlations were performed. Findings: Fatigue was mild at baseline and rose to moderate levels on Day 3 after CTX2 and 3. Sleep quality was poor both in the month before CTX1 and during CTX2 and 3. Actigraphy data revealed impaired circadian activity rhythms compared to healthy adults. Acrophase was the only circadian variable within normal limits. 24-hr activity rhythms measures were 66-72% (amplitude) to 78-83% (mesor) of values obtained in healthy young adults. Rhythm consistency measured as r24 from day to day was lower during the first week after CTX1-3 (.33 - .34) than median values obtained previously from metastatic colon and rectal cancer patients (.41- .58). No pattern of relationships was found between fatigue, sleep quality and circadian variables. Fatigue increased over time. Relevance to nursing practice: Screen and treat moderate-severe fatigue and sleep disturbances using established guidelines.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleFatigue, Sleep Quality, and Circadian Activity Rhythms during Colon and Rectal Cancer Adjuvant Chemotherapyen_GB
dc.identifier.urihttp://hdl.handle.net/10755/159879-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Fatigue, Sleep Quality, and Circadian Activity Rhythms during Colon and Rectal Cancer Adjuvant Chemotherapy</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2010</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Berger, Ann, PhD, RN, AOCN, FAAN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Nebraska Medical Center</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">College of Nursing, 985330 NE MED CENTER, Omaha, NE, 68198-5330, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">402-559-4957</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">aberger@unmc.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">A.M. Berger, C. Visovsky, H. Marunda, J. Yurkovich, College of Nursing, University of Nebraska Medical Center, Omaha, NE; J.L. Grem, Department of Medicine, University of Nebraska Medical Center, Omaha, NE;</td></tr><tr><td colspan="2" class="item-abstract">Problem/Purpose: Fatigue is the most frequent and distressing toxicity of colon and rectal cancer chemotherapy (CTX), but few studies have focused on fatigue and its relationship with sleep quality and circadian activity rhythms during adjuvant CTX. This presentation describes patterns of fatigue, sleep quality, and circadian activity rhythms and relationships between variables during the first week of three, 2-week cycles of colon and rectal cancer adjuvant chemotherapy treatment (CTX1-3) and at 6 weeks. Theoretical Framework: Piper's Integrated Fatigue Model proposes fatigue is influenced by activity/rest and sleep/wake patterns. Methods/Design: A longitudinal, descriptive, correlational, design was used for this feasibility study conducted in Midwestern US medical oncology clinics. The sample was 21 participants; most were middle-aged, partnered, employed, with post secondary education. Established measures used were: Piper Fatigue Scale (fatigue), Pittsburgh Sleep Quality Index (sleep quality), wrist actigraphy [circadian activity rhythms: mesor, amplitude, acrophase, circadian quotient, and 24-hr autocorrelation (r24)], and demographic/medical data form. Analysis: Descriptive statistics, RM-ANOVAs and Pearson/Spearman correlations were performed. Findings: Fatigue was mild at baseline and rose to moderate levels on Day 3 after CTX2 and 3. Sleep quality was poor both in the month before CTX1 and during CTX2 and 3. Actigraphy data revealed impaired circadian activity rhythms compared to healthy adults. Acrophase was the only circadian variable within normal limits. 24-hr activity rhythms measures were 66-72% (amplitude) to 78-83% (mesor) of values obtained in healthy young adults. Rhythm consistency measured as r24 from day to day was lower during the first week after CTX1-3 (.33 - .34) than median values obtained previously from metastatic colon and rectal cancer patients (.41- .58). No pattern of relationships was found between fatigue, sleep quality and circadian variables. Fatigue increased over time. Relevance to nursing practice: Screen and treat moderate-severe fatigue and sleep disturbances using established guidelines.</td></tr></table>en_GB
dc.date.available2011-10-26T22:25:12Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:25:12Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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