2.50
Hdl Handle:
http://hdl.handle.net/10755/160004
Type:
Presentation
Title:
Fatigue and Cytokines in Terminal Cancer Patients
Abstract:
Fatigue and Cytokines in Terminal Cancer Patients
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2007
Author:Tsai, Yi-Jiuan
P.I. Institution Name:Chang Jung Christian University
Contact Address:Nursing, No.111 Yuhe Rd., Tainan, 701 Taiwan, Tainan, 00701, Taiwan
Co-Authors:L.W. Suen, Nursing, Chang Jung Christian University, Tainan, TAIWAN
Since 1982, malignant tumors have been the leading cause of death in Taiwan. Almost all patients of cancer complain of some degree of fatigue and over 90% experience fatigue in the terminal stage. Fatigue is one of the most common symptoms and has a severe impact on the patient's quality of life. Many studies have shown that fatigue is associated with cytokines in tumor progression, and elevated levels of several cytokines have been found in cancer patients. Cytokines are a group of proteinaceous signaling compounds that function in intercellular communication, mediating inflammation and immunological reactions. The purpose of this proposed longitudinal study is to examine the correlation between fatigue and cytokine levels in terminal cancer patients. The investigator plans to recruit 60 patients from a palliative care unit at a local hospital in southern Taiwan. Patient 18 years and older with terminal cancer will be included in this study, and those who are not able to communicate will be excluded. Blood and saliva samples will be collected on day 1 (after being admitted), day 8, and day 15. Fatigue severity questionnaires will be administered as well. The blood sample will be used to examine BUN, creatinine, GOT, GPT, pre-albumin, and cytokines (TNF-alpha, interferon-chi, interleukin 10). The saliva will be analyzed for cytokines (TNF- alpha, interferon-chi, interleukin 10) only. The cytokine levels in both the blood and saliva will be examined using enzyme-link immunosorbent assay (ELISA). Three instruments will be used in this study to investigate subjective fatigue syndrome: the Fatigue Symptom Inventory, Symptom Distress Scale, and WHOQOL-BREF. Pearson correlation and repeated measurements will be used for data analysis. The data collection is still in progress. Understanding the relationship between fatigue and cytokines will make it possible to develop interventions that aid patients with fatigue.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleFatigue and Cytokines in Terminal Cancer Patientsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/160004-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Fatigue and Cytokines in Terminal Cancer Patients</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2007</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Tsai, Yi-Jiuan</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Chang Jung Christian University</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Nursing, No.111 Yuhe Rd., Tainan, 701 Taiwan, Tainan, 00701, Taiwan</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">tjeureka@yahoo.com</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">L.W. Suen, Nursing, Chang Jung Christian University, Tainan, TAIWAN</td></tr><tr><td colspan="2" class="item-abstract">Since 1982, malignant tumors have been the leading cause of death in Taiwan. Almost all patients of cancer complain of some degree of fatigue and over 90% experience fatigue in the terminal stage. Fatigue is one of the most common symptoms and has a severe impact on the patient's quality of life. Many studies have shown that fatigue is associated with cytokines in tumor progression, and elevated levels of several cytokines have been found in cancer patients. Cytokines are a group of proteinaceous signaling compounds that function in intercellular communication, mediating inflammation and immunological reactions. The purpose of this proposed longitudinal study is to examine the correlation between fatigue and cytokine levels in terminal cancer patients. The investigator plans to recruit 60 patients from a palliative care unit at a local hospital in southern Taiwan. Patient 18 years and older with terminal cancer will be included in this study, and those who are not able to communicate will be excluded. Blood and saliva samples will be collected on day 1 (after being admitted), day 8, and day 15. Fatigue severity questionnaires will be administered as well. The blood sample will be used to examine BUN, creatinine, GOT, GPT, pre-albumin, and cytokines (TNF-alpha, interferon-chi, interleukin 10). The saliva will be analyzed for cytokines (TNF- alpha, interferon-chi, interleukin 10) only. The cytokine levels in both the blood and saliva will be examined using enzyme-link immunosorbent assay (ELISA). Three instruments will be used in this study to investigate subjective fatigue syndrome: the Fatigue Symptom Inventory, Symptom Distress Scale, and WHOQOL-BREF. Pearson correlation and repeated measurements will be used for data analysis. The data collection is still in progress. Understanding the relationship between fatigue and cytokines will make it possible to develop interventions that aid patients with fatigue.</td></tr></table>en_GB
dc.date.available2011-10-26T22:32:10Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:32:10Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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