Three-year Cumulative Effect of Exacerbations in Chronic Obstructive Pulmonary Disease

2.50
Hdl Handle:
http://hdl.handle.net/10755/160064
Type:
Presentation
Title:
Three-year Cumulative Effect of Exacerbations in Chronic Obstructive Pulmonary Disease
Abstract:
Three-year Cumulative Effect of Exacerbations in Chronic Obstructive Pulmonary Disease
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2006
Author:Kapella, Mary, PhD, RN
P.I. Institution Name:University of Illinois at Chicago
Title:Assistant Professor
Contact Address:Medical-Surgical Nursing, 845 South Damen Ave., Chicago, IL, 60612-7350, USA
Contact Telephone:312-996-9542
Co-Authors:Janet L. Larson, PhD, RN, FAAN, Professor and Margaret K. Covey, PhD, RN, Assistant Professor
Purpose: Exacerbations are common in chronic obstructive pulmonary disease (COPD), but little is known about the burden of exacerbation symptoms. Specific aims of this research were 1) describe dimensions of exacerbation symptoms and 2) examine cumulative effects of exacerbations with respect to functional status. Theoretical/Conceptual Framework: Leidy's model of functional status guided this study. Subjects: 50 people with moderate COPD. Method: Data were collected weekly, monthly (exacerbation data) and annually (other data) for three years. Thirteen exacerbation symptoms were measured and exacerbation burden was calculated (sum of exacerbation frequency, symptom intensity and duration). Two hierarchical linear regressions (HLR) were performed to examine relationships between exacerbations and functional capacity (six-minute walk distance (6MD)) and functional performance (Functional Performance Inventory (FPI Total)) after 3 years of follow-up. Independent variables included: forced expiratory volume in one-second, lean body mass (measured by dual energy x-ray absorptiometry), baseline 6MD and FPI Total, cumulative dose of oral steroids and symptom dimensions. Results: Exacerbation frequency, symptom intensity and symptom duration were highly correlated with each other annually (r > 0.69, p<.001). The final functional capacity model included baseline 6MD and the duration of exacerbation symptoms over 3 years. This model explained 63% of the variance in 6MD measured at the end of year-3 and duration of exacerbation symptoms independently accounted for 7% of the variance. The final functional performance model included baseline FPI-Total and 3-year cumulative oral steroid dose. This model explained 65% of variance in FPI Total measured at the end of year-3 and the cumulative oral steroid dose independently accounted for 8% of the variance. Conclusions: The total time spent in exacerbation and the cumulative steroid usage contributed to declines in functional capacity and functional performance. This highlights the importance of preventing COPD exacerbations. [Poster Presentation]
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleThree-year Cumulative Effect of Exacerbations in Chronic Obstructive Pulmonary Diseaseen_GB
dc.identifier.urihttp://hdl.handle.net/10755/160064-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Three-year Cumulative Effect of Exacerbations in Chronic Obstructive Pulmonary Disease</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2006</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Kapella, Mary, PhD, RN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Illinois at Chicago</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Medical-Surgical Nursing, 845 South Damen Ave., Chicago, IL, 60612-7350, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">312-996-9542</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">mkapel1@uic.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Janet L. Larson, PhD, RN, FAAN, Professor and Margaret K. Covey, PhD, RN, Assistant Professor</td></tr><tr><td colspan="2" class="item-abstract">Purpose: Exacerbations are common in chronic obstructive pulmonary disease (COPD), but little is known about the burden of exacerbation symptoms. Specific aims of this research were 1) describe dimensions of exacerbation symptoms and 2) examine cumulative effects of exacerbations with respect to functional status. Theoretical/Conceptual Framework: Leidy's model of functional status guided this study. Subjects: 50 people with moderate COPD. Method: Data were collected weekly, monthly (exacerbation data) and annually (other data) for three years. Thirteen exacerbation symptoms were measured and exacerbation burden was calculated (sum of exacerbation frequency, symptom intensity and duration). Two hierarchical linear regressions (HLR) were performed to examine relationships between exacerbations and functional capacity (six-minute walk distance (6MD)) and functional performance (Functional Performance Inventory (FPI Total)) after 3 years of follow-up. Independent variables included: forced expiratory volume in one-second, lean body mass (measured by dual energy x-ray absorptiometry), baseline 6MD and FPI Total, cumulative dose of oral steroids and symptom dimensions. Results: Exacerbation frequency, symptom intensity and symptom duration were highly correlated with each other annually (r &gt; 0.69, p&lt;.001). The final functional capacity model included baseline 6MD and the duration of exacerbation symptoms over 3 years. This model explained 63% of the variance in 6MD measured at the end of year-3 and duration of exacerbation symptoms independently accounted for 7% of the variance. The final functional performance model included baseline FPI-Total and 3-year cumulative oral steroid dose. This model explained 65% of variance in FPI Total measured at the end of year-3 and the cumulative oral steroid dose independently accounted for 8% of the variance. Conclusions: The total time spent in exacerbation and the cumulative steroid usage contributed to declines in functional capacity and functional performance. This highlights the importance of preventing COPD exacerbations. [Poster Presentation]</td></tr></table>en_GB
dc.date.available2011-10-26T22:35:32Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:35:32Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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