2.50
Hdl Handle:
http://hdl.handle.net/10755/160178
Type:
Presentation
Title:
Selected cytokines and activity in ICU patients: Is there a relationship?
Abstract:
Selected cytokines and activity in ICU patients: Is there a relationship?
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2005
Author:Winkelman, Chris, PhD, CNP, CCRN
P.I. Institution Name:Case Western Reserve University
Title:Assistant Professor
Contact Address:Nursing Department, 10900 Euclid Ave, Cleveland, OH, 44109, USA
Contact Telephone:216.368-0700
This is an observational, exploratory study to investigate whether
selected cytokines vary between rest and therapeutic activity in COPD
patients in the intensive care unit (ICU). Cytokines influence the onset
and course of inflammation. Low and moderate levels of activity have the
potential to reduce pro-inflammatory cytokines and reset inflammatory
dysfunction in the presence of inflammatory disease. Reduction of
pro-inflammatory cytokines and restoration of inflammatory balance may
lead to improved function and patient outcomes. There is no information
about the influence of activity on cytokines in critically ill adultsùthis
study undertakes to begin to fill this gap in knowledge. Low and moderate
levels of activity in community-dwelling patients with inflammatory
diseases of congestive heart failure, sickle cell anemia, rheumatoid
arthritis, and angina are associated with either static levels or a
reduction in IL-6 or IL-10. This pilot examines whether typical activity
in COPD patients hospitalized in the ICU alters levels of two cytokines
highly associated with adverse outcomes in critically ill adults: IL-6 and
IL-10. The specific aims are: (1) describe the serum levels of IL-6 and
IL-10 at rest in COPD patients during acute exacerbation and (2) compare
the values of IL-6 and IL-10 during rest with those obtained immediately
after clinically prescribed therapeutic activity to see if there are any
differences in this sample and setting. Data analysis will describe
baseline resting data and use ANOVA to compare serum levels of IL-6 and
IL-10 at rest with those obtained after 20 minutes of activity. If typical
activity demonstrates a relationship to cytokine levels, I expect to
develop a program of research that investigates the optimal intensity,
duration, and timing of activity to positively influence cytokines in ICU
patients and, ultimately, patient outcomes in the ICU.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleSelected cytokines and activity in ICU patients: Is there a relationship?en_GB
dc.identifier.urihttp://hdl.handle.net/10755/160178-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Selected cytokines and activity in ICU patients: Is there a relationship?</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2005</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Winkelman, Chris, PhD, CNP, CCRN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Case Western Reserve University</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Nursing Department, 10900 Euclid Ave, Cleveland, OH, 44109, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">216.368-0700</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">chris.winkelman@case.edu</td></tr><tr><td colspan="2" class="item-abstract">This is an observational, exploratory study to investigate whether <br/> selected cytokines vary between rest and therapeutic activity in COPD <br/> patients in the intensive care unit (ICU). Cytokines influence the onset <br/> and course of inflammation. Low and moderate levels of activity have the <br/> potential to reduce pro-inflammatory cytokines and reset inflammatory <br/> dysfunction in the presence of inflammatory disease. Reduction of <br/> pro-inflammatory cytokines and restoration of inflammatory balance may <br/> lead to improved function and patient outcomes. There is no information <br/> about the influence of activity on cytokines in critically ill adults&ugrave;this <br/> study undertakes to begin to fill this gap in knowledge. Low and moderate <br/> levels of activity in community-dwelling patients with inflammatory <br/> diseases of congestive heart failure, sickle cell anemia, rheumatoid <br/> arthritis, and angina are associated with either static levels or a <br/> reduction in IL-6 or IL-10. This pilot examines whether typical activity <br/> in COPD patients hospitalized in the ICU alters levels of two cytokines <br/> highly associated with adverse outcomes in critically ill adults: IL-6 and <br/> IL-10. The specific aims are: (1) describe the serum levels of IL-6 and <br/> IL-10 at rest in COPD patients during acute exacerbation and (2) compare <br/> the values of IL-6 and IL-10 during rest with those obtained immediately <br/> after clinically prescribed therapeutic activity to see if there are any <br/> differences in this sample and setting. Data analysis will describe <br/> baseline resting data and use ANOVA to compare serum levels of IL-6 and <br/> IL-10 at rest with those obtained after 20 minutes of activity. If typical <br/> activity demonstrates a relationship to cytokine levels, I expect to <br/> develop a program of research that investigates the optimal intensity, <br/> duration, and timing of activity to positively influence cytokines in ICU <br/> patients and, ultimately, patient outcomes in the ICU.</td></tr></table>en_GB
dc.date.available2011-10-26T22:41:56Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:41:56Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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