2.50
Hdl Handle:
http://hdl.handle.net/10755/160222
Type:
Presentation
Title:
Composition of Lipoproteins Across a Spectrum of Glucose Tolerance
Abstract:
Composition of Lipoproteins Across a Spectrum of Glucose Tolerance
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2007
Author:Kent, Denise, MS, APN, CNP
P.I. Institution Name:University of Illinois at Chicago
Contact Address:Medical Surgical Nursing - NURS 760, 845 South Damen, Chicago, IL, 60612, USA
Co-Authors:D. Smith, D. Calvin, & L. Quinn, Medical Surgical Nursing, University of Illinois at Chicago College of Nursing; J. Briller, Department of Cardiology, University of Illinois College of Medicine; and Y. Watkins, School of Public Health, University of Illin
Theoretical Framework: Core components of the major plasma lipoproteins (very low-density lipoproteins [VLDL], low-density lipoproteins [LDL], and high-density lipoproteins [HDL]) include cholesteryl ester (CE) and triglyceride (TG). While the concentrations of plasma lipoproteins may be normal, the ratio of CE to TG may be altered. Compositional changes in core lipid components (e.g., TG-enriched HDL) and LDL particle size are associated with increased atherogenesis. In addition, small, dense LDL particles are associated with increased CVD risk. Measurement of lipoprotein subclasses and particle size may more accurately assess CVD risk than quantitative measurements alone. Purpose: Baseline lipoproteins and particle size were examined across a spectrum of glucose tolerance (diabetes [DM], impaired glucose tolerance [IGT] and normal glucose tolerance [NGT]) in subject participating in an ongoing clinical trial. Methods: Baseline lipoprotein measurements were collected prior to the initial study intervention (30 minutes of aerobic exercise at 65% V02 Max). Plasma specimens were collected in EDTA tubes and analyzed using nuclear magnetic resonance (NMR) technology (LipoScience, Raleigh, NC). Differences in plasma lipoproteins by glucose tolerance status were analyzed using one-way ANOVA. Results: There are 38 subjects (27 females; 11 males) enrolled in the study. Study characteristics include: NGT (n=20); IGT (n=7); type 2 DM (n=11). There were no statistical differences between groups with respect to age (44 &+/- 8.6 years [group mean +/- SD]); waist circumference (41.6 +/- 4.4 inches); percent body fat (36.1 +/- 7.0%); BMI (35.1 +/- 3.5 kg/m2) and V02 Max (24.7 +/- 3.5 ml/kg). The medium-sized LDL particles were significantly higher in the IGT subjects than in the NGT subjects (236.0 +/- 90.63 [IGT] vs.182.44 +/- 91.53 [NGT]; p < .05). The number of small LDL particles was higher in IGT subjects than in NGT subjects (1108.75 +/- 452.66 vs. 888.0 +/- 413.20; p < .05). Implications: These findings support the increase in cardiovascular risk in the progression from NGT to IGT. Future studies by nurse researchers are needed to assess the effects of lifestyle interventions (e.g. aerobic exercise) on compositional changes across a spectrum of glucose tolerance.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleComposition of Lipoproteins Across a Spectrum of Glucose Toleranceen_GB
dc.identifier.urihttp://hdl.handle.net/10755/160222-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Composition of Lipoproteins Across a Spectrum of Glucose Tolerance</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2007</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Kent, Denise, MS, APN, CNP</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Illinois at Chicago</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Medical Surgical Nursing - NURS 760, 845 South Damen, Chicago, IL, 60612, USA</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">dlynch7@uic.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">D. Smith, D. Calvin, &amp; L. Quinn, Medical Surgical Nursing, University of Illinois at Chicago College of Nursing; J. Briller, Department of Cardiology, University of Illinois College of Medicine; and Y. Watkins, School of Public Health, University of Illin</td></tr><tr><td colspan="2" class="item-abstract">Theoretical Framework: Core components of the major plasma lipoproteins (very low-density lipoproteins [VLDL], low-density lipoproteins [LDL], and high-density lipoproteins [HDL]) include cholesteryl ester (CE) and triglyceride (TG). While the concentrations of plasma lipoproteins may be normal, the ratio of CE to TG may be altered. Compositional changes in core lipid components (e.g., TG-enriched HDL) and LDL particle size are associated with increased atherogenesis. In addition, small, dense LDL particles are associated with increased CVD risk. Measurement of lipoprotein subclasses and particle size may more accurately assess CVD risk than quantitative measurements alone. Purpose: Baseline lipoproteins and particle size were examined across a spectrum of glucose tolerance (diabetes [DM], impaired glucose tolerance [IGT] and normal glucose tolerance [NGT]) in subject participating in an ongoing clinical trial. Methods: Baseline lipoprotein measurements were collected prior to the initial study intervention (30 minutes of aerobic exercise at 65% V02 Max). Plasma specimens were collected in EDTA tubes and analyzed using nuclear magnetic resonance (NMR) technology (LipoScience, Raleigh, NC). Differences in plasma lipoproteins by glucose tolerance status were analyzed using one-way ANOVA. Results: There are 38 subjects (27 females; 11 males) enrolled in the study. Study characteristics include: NGT (n=20); IGT (n=7); type 2 DM (n=11). There were no statistical differences between groups with respect to age (44 &amp;+/- 8.6 years [group mean +/- SD]); waist circumference (41.6 +/- 4.4 inches); percent body fat (36.1 +/- 7.0%); BMI (35.1 +/- 3.5 kg/m2) and V02 Max (24.7 +/- 3.5 ml/kg). The medium-sized LDL particles were significantly higher in the IGT subjects than in the NGT subjects (236.0 +/- 90.63 [IGT] vs.182.44 +/- 91.53 [NGT]; p &lt; .05). The number of small LDL particles was higher in IGT subjects than in NGT subjects (1108.75 +/- 452.66 vs. 888.0 +/- 413.20; p &lt; .05). Implications: These findings support the increase in cardiovascular risk in the progression from NGT to IGT. Future studies by nurse researchers are needed to assess the effects of lifestyle interventions (e.g. aerobic exercise) on compositional changes across a spectrum of glucose tolerance.</td></tr></table>en_GB
dc.date.available2011-10-26T22:44:23Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:44:23Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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