A Description of Patterns, Predictors, and Outcomes of Immunosuppressive Medication Noncompliance in Adult Renal Transplant Recipients

2.50
Hdl Handle:
http://hdl.handle.net/10755/160290
Type:
Presentation
Title:
A Description of Patterns, Predictors, and Outcomes of Immunosuppressive Medication Noncompliance in Adult Renal Transplant Recipients
Abstract:
A Description of Patterns, Predictors, and Outcomes of Immunosuppressive Medication Noncompliance in Adult Renal Transplant Recipients
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2004
Author:Russell, Cynthia, PhD, RN
Title:Assistant Professor
Contact Address:MU Sinclair SON, 12101 South Route N, Columbia, MO, 65203, USA
Co-Authors:Catherine Ashbaugh, MSN, RN, Clinical Nurse Specialist; Vicki Conn, PhD, RN, Director of the Office of Research; Nicolas Muruve, MD, Assistant Professor; Richard Madsen, PhD, Professor; Sabina De Geest, PhD, RN, Professor of Nursing and Director
Problem: Medication compliance is variable among adult renal transplant (RT) patients despite the alarming consequences of immunosuppressive medication noncompliance. Extant research has unreliably estimated MNC, failed to identify patterns of immunosuppressive medication noncompliance, and not determined the relationship between immunosuppressive medication noncompliance and serious consequences due to methodological limitations. Theoretical framework: The framework for this study is Bandura’s Social Cognitive Theory. Design/Purpose: This prospective, descriptive, longitudinal pilot study will provide preliminary estimates of 1) patterns of immunosuppressive medication noncompliance, 2) the extent to which depression, medication self-efficacy, and social support predict immunosuppressive medication noncompliance, and 3) the occurrence of infection, acute and chronic rejection, graft loss, and death outcomes in relationship to immunosuppressive medication noncompliance. Methodology: Ten adult RT recipients have been recruited and will be followed for 6 months. Baseline depression, social support, and medication self-efficacy were measured using psychometrically sound instruments. Immunosuppressive medication compliance is being measured for 6 months using highly valid and reliable MEMS 5 TrackCAPs. Concurrently, patient outcome data (infection, rejection, graft loss, & death) will be extracted from records. Analysis: Descriptive, bivariate, and ordinary regression statistics will be used to analyze the data. Importance/relevance: This project is a preliminary study that will be followed by a larger prospective study to provide more precise estimates of predictors and consequences of immunosuppressive medication noncompliance and ultimately by intervention trials to reduce immunosuppressive medication noncompliance and subsequent negative outcomes. The proposed pilot study is an important first step in a program of research that addresses the Healthy People 2010 initiative of reducing chronic kidney disease complications, disability, death, and economic costs by optimizing the transplantation treatment success.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleA Description of Patterns, Predictors, and Outcomes of Immunosuppressive Medication Noncompliance in Adult Renal Transplant Recipientsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/160290-
dc.description.abstract<table><tr><td colspan="2" class="item-title">A Description of Patterns, Predictors, and Outcomes of Immunosuppressive Medication Noncompliance in Adult Renal Transplant Recipients</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Russell, Cynthia, PhD, RN</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">MU Sinclair SON, 12101 South Route N, Columbia, MO, 65203, USA</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Catherine Ashbaugh, MSN, RN, Clinical Nurse Specialist; Vicki Conn, PhD, RN, Director of the Office of Research; Nicolas Muruve, MD, Assistant Professor; Richard Madsen, PhD, Professor; Sabina De Geest, PhD, RN, Professor of Nursing and Director</td></tr><tr><td colspan="2" class="item-abstract">Problem: Medication compliance is variable among adult renal transplant (RT) patients despite the alarming consequences of immunosuppressive medication noncompliance. Extant research has unreliably estimated MNC, failed to identify patterns of immunosuppressive medication noncompliance, and not determined the relationship between immunosuppressive medication noncompliance and serious consequences due to methodological limitations. Theoretical framework: The framework for this study is Bandura&rsquo;s Social Cognitive Theory. Design/Purpose: This prospective, descriptive, longitudinal pilot study will provide preliminary estimates of 1) patterns of immunosuppressive medication noncompliance, 2) the extent to which depression, medication self-efficacy, and social support predict immunosuppressive medication noncompliance, and 3) the occurrence of infection, acute and chronic rejection, graft loss, and death outcomes in relationship to immunosuppressive medication noncompliance. Methodology: Ten adult RT recipients have been recruited and will be followed for 6 months. Baseline depression, social support, and medication self-efficacy were measured using psychometrically sound instruments. Immunosuppressive medication compliance is being measured for 6 months using highly valid and reliable MEMS 5 TrackCAPs. Concurrently, patient outcome data (infection, rejection, graft loss, &amp; death) will be extracted from records. Analysis: Descriptive, bivariate, and ordinary regression statistics will be used to analyze the data. Importance/relevance: This project is a preliminary study that will be followed by a larger prospective study to provide more precise estimates of predictors and consequences of immunosuppressive medication noncompliance and ultimately by intervention trials to reduce immunosuppressive medication noncompliance and subsequent negative outcomes. The proposed pilot study is an important first step in a program of research that addresses the Healthy People 2010 initiative of reducing chronic kidney disease complications, disability, death, and economic costs by optimizing the transplantation treatment success. </td></tr></table>en_GB
dc.date.available2011-10-26T22:48:10Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:48:10Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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