2.50
Hdl Handle:
http://hdl.handle.net/10755/160298
Type:
Presentation
Title:
Coping and Immune Function in Multiple Sclerosis
Abstract:
Coping and Immune Function in Multiple Sclerosis
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2004
Author:Sorenson, Matthew, PhD, RN
Title:Fellow
Contact Address:Research - Bldg One Rm B360, Roosevelt Rd. and Fifth Ave (151), Hines, IL, 60141, USA
Co-Authors:Linda Janusek, PhD, RN, Professor, Herbert Mathews, PhD, Professor
Perceived stress has been demonstrated to modulate cytokine expression and secretion. As coping is believed to modulate levels of perceived stress, it was the purpose of this study to examine the relationships among disease symptomatology, perceived stress, dispositional coping style, and cytokine production as induced from peripheral blood mononuclear cells in normative controls (n=38) and outpatients with Multiple Sclerosis (n=43). Cytokine production was induced using two separate methods, lipopolysacchride and a mixture of phytohaemagglutin and phorbol-12-myristate-13-acetate. Coping was measured through administration of the Jalowiec Coping Scale in order to provide a means of assessing the presence, and perceived effectiveness of eight dispositional coping styles. In those with multiple sclerosis (MS), the use and effectiveness of predominately emotion-focused coping strategies significantly and directly correlated with the production of IL-2 and IL-12. As well, those cytokines that significantly correlated with coping in those with MS were distinct from those cytokines found to significantly correlate with perceived stress and mood disturbance (IL-6, IL-10). In normative control subjects, the use of emotion-focused coping styles negatively correlated with the production of IL-10 and IFN-g. Within control subjects, IFN-g had been found to exhibit a pattern of positive correlation with mood disturbance, while perceived stress was directly correlated with TNF-a and IL-12. These results suggest that coping style in normative controls may modulate the level of mood disturbance and perceived stress. Coping style may also be associated with the expression of select cytokines that may affect MS disease progression and course, indicating that the immunologic effect of coping style differs in those with MS from normative control subjects. The coping strategies available to those with a chronic disease such as MS, may also be limited to strategies that are more emotion-focused.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleCoping and Immune Function in Multiple Sclerosisen_GB
dc.identifier.urihttp://hdl.handle.net/10755/160298-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Coping and Immune Function in Multiple Sclerosis </td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Sorenson, Matthew, PhD, RN</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Fellow</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Research - Bldg One Rm B360, Roosevelt Rd. and Fifth Ave (151), Hines, IL, 60141, USA</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Linda Janusek, PhD, RN, Professor, Herbert Mathews, PhD, Professor </td></tr><tr><td colspan="2" class="item-abstract">Perceived stress has been demonstrated to modulate cytokine expression and secretion. As coping is believed to modulate levels of perceived stress, it was the purpose of this study to examine the relationships among disease symptomatology, perceived stress, dispositional coping style, and cytokine production as induced from peripheral blood mononuclear cells in normative controls (n=38) and outpatients with Multiple Sclerosis (n=43). Cytokine production was induced using two separate methods, lipopolysacchride and a mixture of phytohaemagglutin and phorbol-12-myristate-13-acetate. Coping was measured through administration of the Jalowiec Coping Scale in order to provide a means of assessing the presence, and perceived effectiveness of eight dispositional coping styles. In those with multiple sclerosis (MS), the use and effectiveness of predominately emotion-focused coping strategies significantly and directly correlated with the production of IL-2 and IL-12. As well, those cytokines that significantly correlated with coping in those with MS were distinct from those cytokines found to significantly correlate with perceived stress and mood disturbance (IL-6, IL-10). In normative control subjects, the use of emotion-focused coping styles negatively correlated with the production of IL-10 and IFN-g. Within control subjects, IFN-g had been found to exhibit a pattern of positive correlation with mood disturbance, while perceived stress was directly correlated with TNF-a and IL-12. These results suggest that coping style in normative controls may modulate the level of mood disturbance and perceived stress. Coping style may also be associated with the expression of select cytokines that may affect MS disease progression and course, indicating that the immunologic effect of coping style differs in those with MS from normative control subjects. The coping strategies available to those with a chronic disease such as MS, may also be limited to strategies that are more emotion-focused. </td></tr></table>en_GB
dc.date.available2011-10-26T22:48:37Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T22:48:37Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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