2.50
Hdl Handle:
http://hdl.handle.net/10755/160682
Type:
Presentation
Title:
Morphometry of rat pup brains following paternal alcohol exposure
Abstract:
Morphometry of rat pup brains following paternal alcohol exposure
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2001
Author:Jamerson, Patricia
P.I. Institution Name:University of Missouri-St. Louis
Contact Address:Barnes College of Nursing, 8001 Natural Bridge Road, St. Louis, MO, 63121, USA
Contact Telephone:314.516.6729
Neurologic effects on the offspring of women exposed to alcohol during pregnancy have been well described, however there is a paucity of literature regarding morphologic changes in the nervous system following paternal exposures. The purpose of this study was to determine if measurable differences in brain layer morphometry and total cortical thickness occurred in rat pups following paternal exposure to alcohol. An experimental design was used to compare morphometric measures among pups sired by control males and 2 treatment groups: pups sired during chronic male alcohol exposure and pups sired by abstinent, but previously exposed males. At 28 days of age, the pups' brains were removed following anesthetization and prepared using routine histological methods. Using light microscopy, the thickness of the frontal cortex and each of the 6 cortical layers was measured. Analysis of the data revealed no differences between treatment groups. However, a significant increase in overall cortical thickness and cortical layers 1, 3, 5, and 6 occurred in both treatment groups when compared to control pups. These findings provide an anatomical explanation for the neurobehavioral changes seen in offspring following paternal alcohol exposure and suggest a genomic mechanism.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleMorphometry of rat pup brains following paternal alcohol exposureen_GB
dc.identifier.urihttp://hdl.handle.net/10755/160682-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Morphometry of rat pup brains following paternal alcohol exposure</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2001</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Jamerson, Patricia</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Missouri-St. Louis</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">Barnes College of Nursing, 8001 Natural Bridge Road, St. Louis, MO, 63121, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">314.516.6729</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">jamersonp@msx.umsl.edu</td></tr><tr><td colspan="2" class="item-abstract">Neurologic effects on the offspring of women exposed to alcohol during pregnancy have been well described, however there is a paucity of literature regarding morphologic changes in the nervous system following paternal exposures. The purpose of this study was to determine if measurable differences in brain layer morphometry and total cortical thickness occurred in rat pups following paternal exposure to alcohol. An experimental design was used to compare morphometric measures among pups sired by control males and 2 treatment groups: pups sired during chronic male alcohol exposure and pups sired by abstinent, but previously exposed males. At 28 days of age, the pups' brains were removed following anesthetization and prepared using routine histological methods. Using light microscopy, the thickness of the frontal cortex and each of the 6 cortical layers was measured. Analysis of the data revealed no differences between treatment groups. However, a significant increase in overall cortical thickness and cortical layers 1, 3, 5, and 6 occurred in both treatment groups when compared to control pups. These findings provide an anatomical explanation for the neurobehavioral changes seen in offspring following paternal alcohol exposure and suggest a genomic mechanism.</td></tr></table>en_GB
dc.date.available2011-10-26T23:08:57Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:08:57Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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