2.50
Hdl Handle:
http://hdl.handle.net/10755/160834
Type:
Presentation
Title:
Association of Variants in FTO Genes in Early-Onset Obese Children at Ages 4 to 8
Abstract:
Association of Variants in FTO Genes in Early-Onset Obese Children at Ages 4 to 8
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2009
Author:Seal, Nuananong
P.I. Institution Name:University of North Dakota
Contact Address:430 Ocford Street, Nursing Building Room341, Grand Forks, ND, 58202-9025, USA
Contact Telephone:701-777-4544
Co-Authors:N. Seal, Nursing, University of Norh Dakota, Grand Forks, ND;
The rise in childhood obesity is acknowledged as a major health problem worldwide. The development of obesity is multifactorial and includes interactions between variant alleles and environments that predispose individuals toward development of the disease. Family and twin studies have shown that genetic factor contributes approximately 40 to 70 % to the variation in common obesity. Recent genome-wide association studies reported that the FTO gene (fat mass and obesity associated) is strongly associated with obesity. The FTO is a gene located in chromosome region 16q12.2. These studies have found associations of several single nucleotide polymorphisms (SNPs) in the FTO with body mass index (BMI) and obesity, particularly rs1421085, rs17817449, and rs9939609 in European adults and children at birth and at aged 7 to 14 years. No evidence; however, of these associations has been investigated in early childhood aged 4 to 8 years. Childhood obesity increases morbidity and mortality and its effects on a number of chronic conditions in adulthood such as type 2 diabetes, cardiovascular disease are substantial. This proposed pilot is the first study to investigate the recently reported associations between variants in the FTO gene (rs1421085, rs17817449 and rs9939609) and obesity related phenotypes (BMI, waist circumference, and body fat mass) in children aged 4 to 8. The specific aims of this research include: Aim 1) To investigate the associations of rs1421085, rs17817449, and rs9939609 in FTO gene with lean and severe obese children. Aim 2) To investigate the associations of rs1421085, rs17817449 and rs9939609 in FTO gene with extremely discordant sibling pairs. An outcome of this research may provide important preliminary data into the genetic aspects of obesity which can lead to a health promotion plan development for lifestyle modification as well as individual and/or family genetic counseling for the prevention of obesity.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleAssociation of Variants in FTO Genes in Early-Onset Obese Children at Ages 4 to 8en_GB
dc.identifier.urihttp://hdl.handle.net/10755/160834-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Association of Variants in FTO Genes in Early-Onset Obese Children at Ages 4 to 8</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2009</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Seal, Nuananong</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of North Dakota</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">430 Ocford Street, Nursing Building Room341, Grand Forks, ND, 58202-9025, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">701-777-4544</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">lekseal@mail.und.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">N. Seal, Nursing, University of Norh Dakota, Grand Forks, ND;</td></tr><tr><td colspan="2" class="item-abstract">The rise in childhood obesity is acknowledged as a major health problem worldwide. The development of obesity is multifactorial and includes interactions between variant alleles and environments that predispose individuals toward development of the disease. Family and twin studies have shown that genetic factor contributes approximately 40 to 70 % to the variation in common obesity. Recent genome-wide association studies reported that the FTO gene (fat mass and obesity associated) is strongly associated with obesity. The FTO is a gene located in chromosome region 16q12.2. These studies have found associations of several single nucleotide polymorphisms (SNPs) in the FTO with body mass index (BMI) and obesity, particularly rs1421085, rs17817449, and rs9939609 in European adults and children at birth and at aged 7 to 14 years. No evidence; however, of these associations has been investigated in early childhood aged 4 to 8 years. Childhood obesity increases morbidity and mortality and its effects on a number of chronic conditions in adulthood such as type 2 diabetes, cardiovascular disease are substantial. This proposed pilot is the first study to investigate the recently reported associations between variants in the FTO gene (rs1421085, rs17817449 and rs9939609) and obesity related phenotypes (BMI, waist circumference, and body fat mass) in children aged 4 to 8. The specific aims of this research include: Aim 1) To investigate the associations of rs1421085, rs17817449, and rs9939609 in FTO gene with lean and severe obese children. Aim 2) To investigate the associations of rs1421085, rs17817449 and rs9939609 in FTO gene with extremely discordant sibling pairs. An outcome of this research may provide important preliminary data into the genetic aspects of obesity which can lead to a health promotion plan development for lifestyle modification as well as individual and/or family genetic counseling for the prevention of obesity.</td></tr></table>en_GB
dc.date.available2011-10-26T23:11:25Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:11:25Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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