Stimulation of the Lateral Hypothalamus Produces Analgesia in the Mustard Oil-Induced Inflammatory Pain Model in Rats

2.50
Hdl Handle:
http://hdl.handle.net/10755/161172
Type:
Presentation
Title:
Stimulation of the Lateral Hypothalamus Produces Analgesia in the Mustard Oil-Induced Inflammatory Pain Model in Rats
Abstract:
Stimulation of the Lateral Hypothalamus Produces Analgesia in the Mustard Oil-Induced Inflammatory Pain Model in Rats
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2005
Author:Jeong, Younhee, PhDc, RN
P.I. Institution Name:University of Illinois at Chicago
Title:Research Assistant
Contact Address:College of Nursing, 845 S. Damen Ave., Chicago, IL, 60612, USA
Contact Telephone:312-996-3935
Co-Authors:Janean E. Holden, PhD, Associate Professor
Nurses need to understand how the body processes and modifies pain to
provide optimal care for patients in pain. Previous work from our lab has
shown that stimulation of the lateral hypothalamus (LH) produces analgesia
in acute, non-inflammatory pain, but chronic pain changes the way the body
responds to painful stimuli. To investigate the role of the LH in more
prolonged pain, we measured foot withdrawal latencies (FWL) in female
Sprague-Dawley rats using an inflammatory pain model. For the induction of
inflammatory pain, the rats were lightly anesthetized with sodium
pentobarbital, and mustard oil (20 microliters) was applied on the left ankle.
Either carbachol (125 nmol/0.05 microliters normal saline) or normal saline for
control was microinjected into the left LH, and response latencies
measured. Mustard oil increased pain responses (hyperalgesia) compared to
controls (1.92 plus or minus 0.36 vs. 2.96 plus or minus 0.30 sec, respectively, p < 0.05) that
was reversed by LH stimulation to the level of controls (p>0.05). These
data suggest that the LH is a part of a descending inhibitory pathway for
inflammatory pain. This work was supported by USPHS grants HHS NR04778 from the National
Institute of Nursing Research at the National Institutes of Health.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleStimulation of the Lateral Hypothalamus Produces Analgesia in the Mustard Oil-Induced Inflammatory Pain Model in Ratsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161172-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Stimulation of the Lateral Hypothalamus Produces Analgesia in the Mustard Oil-Induced Inflammatory Pain Model in Rats</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2005</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Jeong, Younhee, PhDc, RN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Illinois at Chicago</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Research Assistant</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">College of Nursing, 845 S. Damen Ave., Chicago, IL, 60612, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">312-996-3935</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">yjeong2@uic.edu</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Janean E. Holden, PhD, Associate Professor</td></tr><tr><td colspan="2" class="item-abstract">Nurses need to understand how the body processes and modifies pain to <br/> provide optimal care for patients in pain. Previous work from our lab has <br/> shown that stimulation of the lateral hypothalamus (LH) produces analgesia <br/> in acute, non-inflammatory pain, but chronic pain changes the way the body <br/> responds to painful stimuli. To investigate the role of the LH in more <br/> prolonged pain, we measured foot withdrawal latencies (FWL) in female <br/> Sprague-Dawley rats using an inflammatory pain model. For the induction of <br/> inflammatory pain, the rats were lightly anesthetized with sodium <br/> pentobarbital, and mustard oil (20 microliters) was applied on the left ankle. <br/> Either carbachol (125 nmol/0.05 microliters normal saline) or normal saline for <br/> control was microinjected into the left LH, and response latencies <br/> measured. Mustard oil increased pain responses (hyperalgesia) compared to <br/> controls (1.92 plus or minus 0.36 vs. 2.96 plus or minus 0.30 sec, respectively, p &lt; 0.05) that <br/> was reversed by LH stimulation to the level of controls (p&gt;0.05). These <br/> data suggest that the LH is a part of a descending inhibitory pathway for <br/> inflammatory pain. This work was supported by USPHS grants HHS NR04778 from the National <br/> Institute of Nursing Research at the National Institutes of Health.</td></tr></table>en_GB
dc.date.available2011-10-26T23:17:04Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:17:04Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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