Increased dietary intake of conjugated linoleic acid preserves muscle mass in mice with cancer cachexia

2.50
Hdl Handle:
http://hdl.handle.net/10755/161197
Type:
Presentation
Title:
Increased dietary intake of conjugated linoleic acid preserves muscle mass in mice with cancer cachexia
Abstract:
Increased dietary intake of conjugated linoleic acid preserves muscle mass in mice with cancer cachexia
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2005
Author:McCarthy, Donna, PhD, RN
P.I. Institution Name:University of Wisconsin - Madison
Title:Professor
Contact Address:School of Nursing, 600 Highland Ave, Room k6-326, Madison, WI, 53792-2455, USA
Contact Telephone:608-263-2476
Cachexia is a syndrome of weight loss, anorexia and fatigue that
significantly impacts quality of life in terminally ill cancer patients.
Skeletal muscle wasting is a major factor associated with fatigue and
interventions to preserve muscle mass in these patients are needed. Tumor
necrosis factor (TNF), a pro-inflammatory cytokine, is thought to play a
major role in the skeletal muscle wasting of cancer cachexia. The
preservation of muscle mass in tumor-bearing animals treated with
indomethacin, a nonsteroidal anti-inflammatory drug that inhibits
cyclo-oxygenase activity, suggests that prostanoid products of arachidonic
acid are also involved in the skeletal muscle wasting of cancer cachexia.
Conjugated linoleic acid (CLA) is a positional isomer of linoleic acid, an
essential fatty acid, which has been shown to reduce the synthesis of TNF
by activated macrophages, and to reduce the activity of cyclo-oxygenase
and synthesis of PGE2 from arachidonic acid. In the present study, we
examined the effects of a diet supplemented with .5% CLA on skeletal
muscle wasting in groups of 6 mice with and without tumors. Mice fed .5%
CLA over the course of 21 days of tumor growth had greater muscle mass
than mice fed the control diet. CLA did not alter muscle mass in the
healthy control animals. Levels of TNF type 1 receptor were increased in
muscles of tumor bearing animals, and were lowered to control levels in
mice fed CLA. These data suggest that CLA reduces the catabolic effects of
TNF in skeletal muscle of tumor-bearing mice. Further research using other
animal models of cancer cachexia is needed to determine if CLA might be
useful in the treatment of muscle wasting in patients with cancer
cachexia.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleIncreased dietary intake of conjugated linoleic acid preserves muscle mass in mice with cancer cachexiaen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161197-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Increased dietary intake of conjugated linoleic acid preserves muscle mass in mice with cancer cachexia</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2005</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">McCarthy, Donna, PhD, RN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Wisconsin - Madison</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">School of Nursing, 600 Highland Ave, Room k6-326, Madison, WI, 53792-2455, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">608-263-2476</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">domccart@wisc.edu</td></tr><tr><td colspan="2" class="item-abstract">Cachexia is a syndrome of weight loss, anorexia and fatigue that <br/> significantly impacts quality of life in terminally ill cancer patients. <br/> Skeletal muscle wasting is a major factor associated with fatigue and <br/> interventions to preserve muscle mass in these patients are needed. Tumor <br/> necrosis factor (TNF), a pro-inflammatory cytokine, is thought to play a <br/> major role in the skeletal muscle wasting of cancer cachexia. The <br/> preservation of muscle mass in tumor-bearing animals treated with <br/> indomethacin, a nonsteroidal anti-inflammatory drug that inhibits <br/> cyclo-oxygenase activity, suggests that prostanoid products of arachidonic <br/> acid are also involved in the skeletal muscle wasting of cancer cachexia. <br/> Conjugated linoleic acid (CLA) is a positional isomer of linoleic acid, an <br/> essential fatty acid, which has been shown to reduce the synthesis of TNF <br/> by activated macrophages, and to reduce the activity of cyclo-oxygenase <br/> and synthesis of PGE2 from arachidonic acid. In the present study, we <br/> examined the effects of a diet supplemented with .5% CLA on skeletal <br/> muscle wasting in groups of 6 mice with and without tumors. Mice fed .5% <br/> CLA over the course of 21 days of tumor growth had greater muscle mass <br/> than mice fed the control diet. CLA did not alter muscle mass in the <br/> healthy control animals. Levels of TNF type 1 receptor were increased in <br/> muscles of tumor bearing animals, and were lowered to control levels in <br/> mice fed CLA. These data suggest that CLA reduces the catabolic effects of <br/> TNF in skeletal muscle of tumor-bearing mice. Further research using other <br/> animal models of cancer cachexia is needed to determine if CLA might be <br/> useful in the treatment of muscle wasting in patients with cancer <br/> cachexia.</td></tr></table>en_GB
dc.date.available2011-10-26T23:17:28Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:17:28Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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