The Contribution of an Elevated Pro-inflammatory Immune Response to the Development of Postpartum Depression

2.50
Hdl Handle:
http://hdl.handle.net/10755/161259
Type:
Presentation
Title:
The Contribution of an Elevated Pro-inflammatory Immune Response to the Development of Postpartum Depression
Abstract:
The Contribution of an Elevated Pro-inflammatory Immune Response to the Development of Postpartum Depression
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2007
Author:Corwin, Elizabeth, PhD, FNP
P.I. Institution Name:The Ohio State University
Contact Address:, 1585 Neil Avenue, Columbus, OH, 43210, USA
The pro-inflammatory immune system response is stimulated in women during labor and delivery and continues to play a key role in postpartum recovery. In a variety of non-pregnant and non-postpartum populations, an excessive pro-inflammatory response has been linked to hypothalamic-pituitary-adrenal (HPA) axis dysregulation and the development of depression. The contribution of the pro-inflammatory immune response to HPA axis dysregulation and depression in postpartum women is unknown. As part of a larger study, 26 postpartum women were recruited within 24-hours of giving birth and provided urine for later analysis of the pro-inflammatory cytokines interluekin-1 beta (IL-1beta) and interleukin-6 (IL-6) at that time (Day 0) and again on postpartum days 7, 14, and 28. Subjects also completed the Centers for Epidemiological Studies-Depression (CES-D) survey on Day 28. Cortisol concentration was measured in urine samples from 13 of the women. Results demonstrated a significant increase in Day 14 IL- beta levels in women who went on to develop symptoms of moderate depression on Day 28 compared to IL-1 beta levels in women who did not develop symptoms of depression (F = 4.50, p = .045). IL-6 was significantly increased on Day 28 in women demonstrating symptoms of severe depression compared to IL-6 levels in women not demonstrating symptoms of depression (F = 5.80, p = .024). In addition, IL-6 levels on Days 0 and 7 were significantly correlated with cortisol concentration on Day 28 (p<.001). On Day 28, IL-1 beta concentration was significantly correlated with cortisol concentration (p = .003). These findings suggest that an elevated pro-inflammatory immune mileu early in the postpartum period may increase a woman's risk of postpartum depression, perhaps via an association with the hormones of the HPA axis.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleThe Contribution of an Elevated Pro-inflammatory Immune Response to the Development of Postpartum Depressionen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161259-
dc.description.abstract<table><tr><td colspan="2" class="item-title">The Contribution of an Elevated Pro-inflammatory Immune Response to the Development of Postpartum Depression</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2007</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Corwin, Elizabeth, PhD, FNP</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">The Ohio State University</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">, 1585 Neil Avenue, Columbus, OH, 43210, USA</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">corwin.56@osu.edu</td></tr><tr><td colspan="2" class="item-abstract">The pro-inflammatory immune system response is stimulated in women during labor and delivery and continues to play a key role in postpartum recovery. In a variety of non-pregnant and non-postpartum populations, an excessive pro-inflammatory response has been linked to hypothalamic-pituitary-adrenal (HPA) axis dysregulation and the development of depression. The contribution of the pro-inflammatory immune response to HPA axis dysregulation and depression in postpartum women is unknown. As part of a larger study, 26 postpartum women were recruited within 24-hours of giving birth and provided urine for later analysis of the pro-inflammatory cytokines interluekin-1 beta (IL-1beta) and interleukin-6 (IL-6) at that time (Day 0) and again on postpartum days 7, 14, and 28. Subjects also completed the Centers for Epidemiological Studies-Depression (CES-D) survey on Day 28. Cortisol concentration was measured in urine samples from 13 of the women. Results demonstrated a significant increase in Day 14 IL- beta levels in women who went on to develop symptoms of moderate depression on Day 28 compared to IL-1 beta levels in women who did not develop symptoms of depression (F = 4.50, p = .045). IL-6 was significantly increased on Day 28 in women demonstrating symptoms of severe depression compared to IL-6 levels in women not demonstrating symptoms of depression (F = 5.80, p = .024). In addition, IL-6 levels on Days 0 and 7 were significantly correlated with cortisol concentration on Day 28 (p&lt;.001). On Day 28, IL-1 beta concentration was significantly correlated with cortisol concentration (p = .003). These findings suggest that an elevated pro-inflammatory immune mileu early in the postpartum period may increase a woman's risk of postpartum depression, perhaps via an association with the hormones of the HPA axis.</td></tr></table>en_GB
dc.date.available2011-10-26T23:18:28Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:18:28Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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