Stability of Synaptic Changes in the Adult Rat Visual Cortex Induced by Behavioral Experience in a Sensory-rich Environment

2.50
Hdl Handle:
http://hdl.handle.net/10755/161288
Type:
Presentation
Title:
Stability of Synaptic Changes in the Adult Rat Visual Cortex Induced by Behavioral Experience in a Sensory-rich Environment
Abstract:
Stability of Synaptic Changes in the Adult Rat Visual Cortex Induced by Behavioral Experience in a Sensory-rich Environment
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2004
Author:Briones, Tess, PhD, RN
Title:Assistant Professor
Contact Address:845 S. Damen Ave, Rm 660 M/C 802, Chicago, IL, 60612, USA
Studies have demonstrated that behavioral experience in a sensory-rich environment produce morphological changes in the brain but it is not clear how long these changes last nor what happens when sensory enrichment is discontinued. Here we examined Layer IV in the visual cortex of adult male rats for the: 1) effects of sensory-rich environment housing on synaptic changes, and 2) persistence of the synaptic changes after withdrawal of sensory enrichment. Fifty-eight adult male (120 days old) Long Evans rats were assigned to either housing in sensory-rich environment called complex environment (EC), a group environment with a changing set of objects, socially paired housing (SC), or individual housing (IC). These rats remained in their assigned environment for 30 days. After 30 days, all rats in SC and some animals from the EC and IC groups were removed and perfused. The remaining animals in EC were then assigned to either remain in EC (ECEC) or be subsequently housed in IC (ECIC) for another 30 days. Similarly, rats in the IC group either remained in IC (ICIC) or were subsequently housed in EC (ICEC) for another 30 days. Electron microscopy was done at the end of the experimental protocol. All rats exposed to EC had significantly more synapses/neuron compared to SC, IC, and ICIC animals. Longer exposure to a complex environment (ECEC) did not result in more synapses however, decreased neuron density was seen. Complex environment-induced synaptic changes persisted for an additional 30 days after withdrawal from EC (ECIC) suggesting that EC-induced morphological changes occur in the brain regardless of age and that once changes occur they tend to persist. Supported by NIH NS10801
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleStability of Synaptic Changes in the Adult Rat Visual Cortex Induced by Behavioral Experience in a Sensory-rich Environmenten_GB
dc.identifier.urihttp://hdl.handle.net/10755/161288-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Stability of Synaptic Changes in the Adult Rat Visual Cortex Induced by Behavioral Experience in a Sensory-rich Environment </td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Briones, Tess, PhD, RN</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">845 S. Damen Ave, Rm 660 M/C 802, Chicago, IL, 60612, USA</td></tr><tr><td colspan="2" class="item-abstract">Studies have demonstrated that behavioral experience in a sensory-rich environment produce morphological changes in the brain but it is not clear how long these changes last nor what happens when sensory enrichment is discontinued. Here we examined Layer IV in the visual cortex of adult male rats for the: 1) effects of sensory-rich environment housing on synaptic changes, and 2) persistence of the synaptic changes after withdrawal of sensory enrichment. Fifty-eight adult male (120 days old) Long Evans rats were assigned to either housing in sensory-rich environment called complex environment (EC), a group environment with a changing set of objects, socially paired housing (SC), or individual housing (IC). These rats remained in their assigned environment for 30 days. After 30 days, all rats in SC and some animals from the EC and IC groups were removed and perfused. The remaining animals in EC were then assigned to either remain in EC (ECEC) or be subsequently housed in IC (ECIC) for another 30 days. Similarly, rats in the IC group either remained in IC (ICIC) or were subsequently housed in EC (ICEC) for another 30 days. Electron microscopy was done at the end of the experimental protocol. All rats exposed to EC had significantly more synapses/neuron compared to SC, IC, and ICIC animals. Longer exposure to a complex environment (ECEC) did not result in more synapses however, decreased neuron density was seen. Complex environment-induced synaptic changes persisted for an additional 30 days after withdrawal from EC (ECIC) suggesting that EC-induced morphological changes occur in the brain regardless of age and that once changes occur they tend to persist. Supported by NIH NS10801 </td></tr></table>en_GB
dc.date.available2011-10-26T23:18:56Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:18:56Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.