Effect of Opioid Receptor Antagonism on Resting Energy Expenditure and Respiratory Quotient in Obese Rats

2.50
Hdl Handle:
http://hdl.handle.net/10755/161321
Type:
Presentation
Title:
Effect of Opioid Receptor Antagonism on Resting Energy Expenditure and Respiratory Quotient in Obese Rats
Abstract:
Effect of Opioid Receptor Antagonism on Resting Energy Expenditure and Respiratory Quotient in Obese Rats
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2004
Author:Jarosz, Patricia, PhD, RN
Title:Assistant Professor
Contact Address:CON, 5557 Cass, Detroit, MI, 48202, USA
Food intake and subsequently body weight are influenced by endogenous opioids acting in the central nervous system. Agonists for the opioid receptor increase food intake, while antagonists reduce food intake. Body weight, however, is the result of food consumed and energy expended. While much has been reported about the effect of opioid antagonism on food intake, much less has been reported about the effect on energy expended. This study investigated the effect of selective antagonism of the kappa and the mu opioid receptor on food intake, body weight, and indicators of energy expenditure in male obese Zucker rats (n=10). Energy expenditure was measured by indirect calorimetry and general activity and body temperature were measured by implanted radio frequency telemetry. Central administration of 30 mcg of the kappa opioid receptor(KOR) antagonist nor-Binaltorphamine resulted in a small reduction in body weight, a significant 34% reduction in food intake (p=.001), a reduction in resting energy expenditure (p=.06), a reduction in respiratory quotient (p=.06), a 14% reduction in general activity, and a reduction in core body temperature. Reduction in body weight as a result of KOR inhibition in this study was related to a decrease in food intake, but not related to an increase in energy expended or activity. Studies involving the mu receptor are in progress. Greater understanding of the biological mechanisms that regulate energy balance is critical to finding effective biobehavioral nursing interventions for overweight and obesity.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleEffect of Opioid Receptor Antagonism on Resting Energy Expenditure and Respiratory Quotient in Obese Ratsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161321-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Effect of Opioid Receptor Antagonism on Resting Energy Expenditure and Respiratory Quotient in Obese Rats </td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2004</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Jarosz, Patricia, PhD, RN</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">CON, 5557 Cass, Detroit, MI, 48202, USA</td></tr><tr><td colspan="2" class="item-abstract">Food intake and subsequently body weight are influenced by endogenous opioids acting in the central nervous system. Agonists for the opioid receptor increase food intake, while antagonists reduce food intake. Body weight, however, is the result of food consumed and energy expended. While much has been reported about the effect of opioid antagonism on food intake, much less has been reported about the effect on energy expended. This study investigated the effect of selective antagonism of the kappa and the mu opioid receptor on food intake, body weight, and indicators of energy expenditure in male obese Zucker rats (n=10). Energy expenditure was measured by indirect calorimetry and general activity and body temperature were measured by implanted radio frequency telemetry. Central administration of 30 mcg of the kappa opioid receptor(KOR) antagonist nor-Binaltorphamine resulted in a small reduction in body weight, a significant 34% reduction in food intake (p=.001), a reduction in resting energy expenditure (p=.06), a reduction in respiratory quotient (p=.06), a 14% reduction in general activity, and a reduction in core body temperature. Reduction in body weight as a result of KOR inhibition in this study was related to a decrease in food intake, but not related to an increase in energy expended or activity. Studies involving the mu receptor are in progress. Greater understanding of the biological mechanisms that regulate energy balance is critical to finding effective biobehavioral nursing interventions for overweight and obesity.</td></tr></table>en_GB
dc.date.available2011-10-26T23:19:30Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:19:30Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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