Correlates of Interleukin-6 Levels with Disease Activity Measures in Adults with Ra and Relationship of Il-6 Levels to Joint Counts after 12-Weeks of Exercise

2.50
Hdl Handle:
http://hdl.handle.net/10755/161399
Type:
Presentation
Title:
Correlates of Interleukin-6 Levels with Disease Activity Measures in Adults with Ra and Relationship of Il-6 Levels to Joint Counts after 12-Weeks of Exercise
Abstract:
Correlates of Interleukin-6 Levels with Disease Activity Measures in Adults with Ra and Relationship of Il-6 Levels to Joint Counts after 12-Weeks of Exercise
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2002
Author:Neuberger, Geri, EdD
P.I. Institution Name:University of Kansas Medical Center
Title:Professor
Contact Address:School of Nursing, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA
Contact Telephone:913.588.3374
Adults with RA (n=220) ages 40-70 were randomly assigned to one of three groups (class exercise, home exercise, or control) in a study based on self regulation. The exercise intervention consisted of 1-hour of low-impact exercise 3 times weekly for 12 weeks. Interleukin-6 (IL-6), c-reactive protein (CRP), sedimentation rate, CBC, functional measures (walk time, grip strength, aerobic fitness), and psychosocial measures (depression, pain, fatigue, social support, benefits and barriers to exercise) were measured at baseline (BL) and at end of the intervention (EI). There were no significant group differences on major demographic variables. Il-6 levels at EI were positively correlated with CRP, Sed rate, granulocytes, WBCs, morning stiffness, swollen joints, pain, and depression. IL-6 had negative correlations with grip strength and social support. To determine if exercise subjects experienced increased joint counts subjects were categorized to a normal IL-6 (< 12.5) or elevated IL-6 (> 12.5) and normal (<.8) or elevated CRP (>.8) levels based on BL values. ANOVAS were conducted to examine differences between normal and elevated IL-6 and CRP groups on the dependent variable joint counts at BL and EI. ANOVAS were conducted for the effects of Time, Group and their Interaction. The IL-6 ANOVA had a significant Group effect for swollen joints (F=7.04, p=.009), and for tender joints significant effects for Time (F=13.62, p<.001) and Group (F=4.25, p=.041). The CRP ANOVA had a significant Interaction effect for swollen joints (F=6.33, p=.013), and a significant Time effect for tender joints (F=7.56, p=.007). Swollen joint counts for both normal IL-6 and CRP groups increased from BL to EI. Swollen joint counts for elevated IL-6 and CRP groups decreased from BL to EI. These findings support that an elevated level of CRP or IL-6 may not be a contraindication for exercise. Additional studies are needed to support these findings.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleCorrelates of Interleukin-6 Levels with Disease Activity Measures in Adults with Ra and Relationship of Il-6 Levels to Joint Counts after 12-Weeks of Exerciseen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161399-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Correlates of Interleukin-6 Levels with Disease Activity Measures in Adults with Ra and Relationship of Il-6 Levels to Joint Counts after 12-Weeks of Exercise</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2002</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Neuberger, Geri, EdD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Kansas Medical Center</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">School of Nursing, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">913.588.3374</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">gneuberg@kumc.edu</td></tr><tr><td colspan="2" class="item-abstract">Adults with RA (n=220) ages 40-70 were randomly assigned to one of three groups (class exercise, home exercise, or control) in a study based on self regulation. The exercise intervention consisted of 1-hour of low-impact exercise 3 times weekly for 12 weeks. Interleukin-6 (IL-6), c-reactive protein (CRP), sedimentation rate, CBC, functional measures (walk time, grip strength, aerobic fitness), and psychosocial measures (depression, pain, fatigue, social support, benefits and barriers to exercise) were measured at baseline (BL) and at end of the intervention (EI). There were no significant group differences on major demographic variables. Il-6 levels at EI were positively correlated with CRP, Sed rate, granulocytes, WBCs, morning stiffness, swollen joints, pain, and depression. IL-6 had negative correlations with grip strength and social support. To determine if exercise subjects experienced increased joint counts subjects were categorized to a normal IL-6 (&lt; 12.5) or elevated IL-6 (&gt; 12.5) and normal (&lt;.8) or elevated CRP (&gt;.8) levels based on BL values. ANOVAS were conducted to examine differences between normal and elevated IL-6 and CRP groups on the dependent variable joint counts at BL and EI. ANOVAS were conducted for the effects of Time, Group and their Interaction. The IL-6 ANOVA had a significant Group effect for swollen joints (F=7.04, p=.009), and for tender joints significant effects for Time (F=13.62, p&lt;.001) and Group (F=4.25, p=.041). The CRP ANOVA had a significant Interaction effect for swollen joints (F=6.33, p=.013), and a significant Time effect for tender joints (F=7.56, p=.007). Swollen joint counts for both normal IL-6 and CRP groups increased from BL to EI. Swollen joint counts for elevated IL-6 and CRP groups decreased from BL to EI. These findings support that an elevated level of CRP or IL-6 may not be a contraindication for exercise. Additional studies are needed to support these findings.</td></tr></table>en_GB
dc.date.available2011-10-26T23:20:44Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:20:44Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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