2.50
Hdl Handle:
http://hdl.handle.net/10755/161431
Type:
Presentation
Title:
Increased Fatigue in Lymphoma Stem Cell Transplant Patients
Abstract:
Increased Fatigue in Lymphoma Stem Cell Transplant Patients
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2003
Author:El-Banna, Majeda
Contact Address:CON, 985330 Nebraska Medical Center, Omaha, NE, 68198-5330, USA
Co-Authors:Lynne Farr; Barbara Friesth; Ann Berger; Elizabeth Schreiner; Foxall, Martha; R. Gregory Bocieck; June Eilers
Peripheral stem cell transplantation (PSCT) is a treatment for cancer that is associated with a variety of troubling symptoms. The most disruptive symptom, fatigue, has a negative impact on quality of life. Fatigue has been studied in various populations for more than 30 years, and its nature remains complex. A relationship between fatigue and disturbances in the hormone melatonin (a pineal hormone) has been suggested. The purpose of this study is to describe the patterns of fatigue, the correlation of fatigue to the hormone melatonin, and to examine the factors that contribute to fatigue during three data collection periods (baseline, chemotherapy, and recovery). A physiologic interactive conceptual framework of fatigue was used. The design is a prospective, descriptive, repeated-measures study. A convenience and purposive sample of Hodgkins and non-Hodgkins lymphoma patients who are scheduled to undergo autologous PSCT were recruited. Study variables were measured by standardized questionnaires: fatigue by Piper Fatigue Scale (PFS), pain by Numerical Pain Intensity Rating Scale (NRS), depression by CES-D, sleep by Stanford Sleepiness Scale (SSS). ActiWatches provided objective sleep measurements. Mucositis was assessed using Oral Assessment Guide (OAG). Melatonin was measured by radio-immune assay of urine samples. Other laboratory tests (hemoglobin, white blood count and neutrophils' count) were taken from patients' files. Primary analysis showed a significant increase in fatigue scores. Fatigue peaked six days after the transplant. Data analysis is continuing and measured factors are being tested for their contribution to fatigue. Investigating the relationship between melatonin rhythm and fatigue levels is new to research in the area of transplantation. A better understanding of the causes of fatigue such as alterations in melatonin will provide a stronger basis for designing treatments and interventions. If a relationship between melatonin disruption can be established; manipulating the timing of melatonin rhythms may offer a new way to decrease fatigue. AN: MN030200
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleIncreased Fatigue in Lymphoma Stem Cell Transplant Patientsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161431-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Increased Fatigue in Lymphoma Stem Cell Transplant Patients</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2003</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">El-Banna, Majeda</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">CON, 985330 Nebraska Medical Center, Omaha, NE, 68198-5330, USA</td></tr><tr class="item-co-authors"><td class="label">Co-Authors:</td><td class="value">Lynne Farr; Barbara Friesth; Ann Berger; Elizabeth Schreiner; Foxall, Martha; R. Gregory Bocieck; June Eilers </td></tr><tr><td colspan="2" class="item-abstract">Peripheral stem cell transplantation (PSCT) is a treatment for cancer that is associated with a variety of troubling symptoms. The most disruptive symptom, fatigue, has a negative impact on quality of life. Fatigue has been studied in various populations for more than 30 years, and its nature remains complex. A relationship between fatigue and disturbances in the hormone melatonin (a pineal hormone) has been suggested. The purpose of this study is to describe the patterns of fatigue, the correlation of fatigue to the hormone melatonin, and to examine the factors that contribute to fatigue during three data collection periods (baseline, chemotherapy, and recovery). A physiologic interactive conceptual framework of fatigue was used. The design is a prospective, descriptive, repeated-measures study. A convenience and purposive sample of Hodgkins and non-Hodgkins lymphoma patients who are scheduled to undergo autologous PSCT were recruited. Study variables were measured by standardized questionnaires: fatigue by Piper Fatigue Scale (PFS), pain by Numerical Pain Intensity Rating Scale (NRS), depression by CES-D, sleep by Stanford Sleepiness Scale (SSS). ActiWatches provided objective sleep measurements. Mucositis was assessed using Oral Assessment Guide (OAG). Melatonin was measured by radio-immune assay of urine samples. Other laboratory tests (hemoglobin, white blood count and neutrophils' count) were taken from patients' files. Primary analysis showed a significant increase in fatigue scores. Fatigue peaked six days after the transplant. Data analysis is continuing and measured factors are being tested for their contribution to fatigue. Investigating the relationship between melatonin rhythm and fatigue levels is new to research in the area of transplantation. A better understanding of the causes of fatigue such as alterations in melatonin will provide a stronger basis for designing treatments and interventions. If a relationship between melatonin disruption can be established; manipulating the timing of melatonin rhythms may offer a new way to decrease fatigue. AN: MN030200 </td></tr></table>en_GB
dc.date.available2011-10-26T23:21:14Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:21:14Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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