Analgesia from lateral hypothalamic stimulation is mediated by the A7 catecholamine cell group

2.50
Hdl Handle:
http://hdl.handle.net/10755/161539
Type:
Presentation
Title:
Analgesia from lateral hypothalamic stimulation is mediated by the A7 catecholamine cell group
Abstract:
Analgesia from lateral hypothalamic stimulation is mediated by the A7 catecholamine cell group
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2001
Author:VanPoppel, Angela
P.I. Institution Name:University of Illinois at Chicago
Contact Address:School of Nursing, 845 South Damen Street, Chicago, IL, 60612, USA
Contact Telephone:312.996.3935
Pain is a clinical entity that affects many people. Stimulation of the lateral hypothalamus (LH) produces analgesia in the spinal cord. However, the LH does not contain norepinephrine (NE) neurons, so it must innervate spinally projecting brainstem NE neurons known to effect analgesia, such as the pontine A7 catecholamine cell group. To determine a functional connection, the cholinergic agonist carbachol was microinjected into the LH of female Sprague-Dawley rats. A significant analgesic effect was obtained on the tail flick test (4.45 sec vs. 2.55 sec). Microinjection of cobalt chloride near the A7 cells, which stops all synaptic activity in the area, blocked this analgesic effect (2.30 vs. 5.19 sec). Because recent work has shown that substance P neurons in the LH project to the A7 area, the substance P receptor antagonist L-703,606 was then microinjected near the A7 cells. The analgesic response from LH stimulation was blocked compared to saline controls (2.27 sec vs. 5.19 sec). These findings suggest that substance P neurons in the LH produce analgesia mediated through spinally projecting A7 cells. As nurses continue to move into advanced practice roles that include prescriptive authority, an expanded physiological knowledge base will provide the foundation for adequate pain control.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleAnalgesia from lateral hypothalamic stimulation is mediated by the A7 catecholamine cell groupen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161539-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Analgesia from lateral hypothalamic stimulation is mediated by the A7 catecholamine cell group</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2001</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">VanPoppel, Angela</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Illinois at Chicago</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">School of Nursing, 845 South Damen Street, Chicago, IL, 60612, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">312.996.3935</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">avp8@aol.com</td></tr><tr><td colspan="2" class="item-abstract">Pain is a clinical entity that affects many people. Stimulation of the lateral hypothalamus (LH) produces analgesia in the spinal cord. However, the LH does not contain norepinephrine (NE) neurons, so it must innervate spinally projecting brainstem NE neurons known to effect analgesia, such as the pontine A7 catecholamine cell group. To determine a functional connection, the cholinergic agonist carbachol was microinjected into the LH of female Sprague-Dawley rats. A significant analgesic effect was obtained on the tail flick test (4.45 sec vs. 2.55 sec). Microinjection of cobalt chloride near the A7 cells, which stops all synaptic activity in the area, blocked this analgesic effect (2.30 vs. 5.19 sec). Because recent work has shown that substance P neurons in the LH project to the A7 area, the substance P receptor antagonist L-703,606 was then microinjected near the A7 cells. The analgesic response from LH stimulation was blocked compared to saline controls (2.27 sec vs. 5.19 sec). These findings suggest that substance P neurons in the LH produce analgesia mediated through spinally projecting A7 cells. As nurses continue to move into advanced practice roles that include prescriptive authority, an expanded physiological knowledge base will provide the foundation for adequate pain control.</td></tr></table>en_GB
dc.date.available2011-10-26T23:23:01Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:23:01Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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