Psychological and Immunological Response to Mindfulness-Based Stress Reduction in HIV Infected Individuals

2.50
Hdl Handle:
http://hdl.handle.net/10755/161607
Type:
Presentation
Title:
Psychological and Immunological Response to Mindfulness-Based Stress Reduction in HIV Infected Individuals
Abstract:
Psychological and Immunological Response to Mindfulness-Based Stress Reduction in HIV Infected Individuals
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2002
Author:Robinson, F.
P.I. Institution Name:University of Illinois at Chicago
Title:Research Associate
Contact Address:College of Nursing, 845 South Damen Avenue, M/C 802, 405E NURS, Chicago, IL, 60612, USA
Contact Telephone:312.996.8217
Background: Stress may hasten HIV disease progression by compromising immune response and increasing viral replication. Conversely, efforts to reduce stress may buffer the physiological effects of stress on HIV disease progression. Purpose: This study determined the effects of a structured, 8-week, mindfulness-based stress reduction (MBSR) program on perceived stress, mood, stress hormone secretion, immune function, and functional health outcomes in HIV-infected subjects. Conceptual Framework: A synthesized framework of psychoneuroimmunology and a transactional model of stress guided the study. Design: A quasi-experimental, repeated measures, control group design was utilized. Subjects were nonrandomly assigned to intervention (N=24) or control group (N=10) and data was collected at baseline, 4 weeks, 8 weeks, and 3 months postintervention (only baseline and 8 weeks for control). Data Analysis: Paired t-tests between baseline scores and scores from subsequent time points and repeated measures ANOVAs were used to determine within group changes. Independent t-tests (calculated on change scores from baseline to 8 weeks) were used to determine between group differences. Results: At 8-weeks, the MBSR group showed significant increases in total functional health score, natural killer (NK) cell activity, NK cell number, and a significant decrease in fatigue. In addition, RANTES levels significantly increased while levels of SDF-1 remained stable. At 3 months postintervention, significant increases in NK cell number and function were maintained and significant decreases in tension, depression, anger, confusion, and total mood disturbance emerged. Control subjects showed no changes in any dependent variables. Within MBSR group changes over time (ANOVA) were found for perceived stress, tension, depression, anger, confusion, fatigue, and NK cell number. Between group differences in change scores were found for NK cell activity and number. Conclusion: These results provide evidence that MBSR may assist in slowing HIV disease progression and may be considered an effective adjunctive therapy in the comprehensive management of HIV.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titlePsychological and Immunological Response to Mindfulness-Based Stress Reduction in HIV Infected Individualsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161607-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Psychological and Immunological Response to Mindfulness-Based Stress Reduction in HIV Infected Individuals</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2002</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Robinson, F.</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Illinois at Chicago</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Research Associate</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">College of Nursing, 845 South Damen Avenue, M/C 802, 405E NURS, Chicago, IL, 60612, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">312.996.8217</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">prphd@uic.edu</td></tr><tr><td colspan="2" class="item-abstract">Background: Stress may hasten HIV disease progression by compromising immune response and increasing viral replication. Conversely, efforts to reduce stress may buffer the physiological effects of stress on HIV disease progression. Purpose: This study determined the effects of a structured, 8-week, mindfulness-based stress reduction (MBSR) program on perceived stress, mood, stress hormone secretion, immune function, and functional health outcomes in HIV-infected subjects. Conceptual Framework: A synthesized framework of psychoneuroimmunology and a transactional model of stress guided the study. Design: A quasi-experimental, repeated measures, control group design was utilized. Subjects were nonrandomly assigned to intervention (N=24) or control group (N=10) and data was collected at baseline, 4 weeks, 8 weeks, and 3 months postintervention (only baseline and 8 weeks for control). Data Analysis: Paired t-tests between baseline scores and scores from subsequent time points and repeated measures ANOVAs were used to determine within group changes. Independent t-tests (calculated on change scores from baseline to 8 weeks) were used to determine between group differences. Results: At 8-weeks, the MBSR group showed significant increases in total functional health score, natural killer (NK) cell activity, NK cell number, and a significant decrease in fatigue. In addition, RANTES levels significantly increased while levels of SDF-1 remained stable. At 3 months postintervention, significant increases in NK cell number and function were maintained and significant decreases in tension, depression, anger, confusion, and total mood disturbance emerged. Control subjects showed no changes in any dependent variables. Within MBSR group changes over time (ANOVA) were found for perceived stress, tension, depression, anger, confusion, fatigue, and NK cell number. Between group differences in change scores were found for NK cell activity and number. Conclusion: These results provide evidence that MBSR may assist in slowing HIV disease progression and may be considered an effective adjunctive therapy in the comprehensive management of HIV.</td></tr></table>en_GB
dc.date.available2011-10-26T23:24:10Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:24:10Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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