Reliability of statistical tools to predict the likelihood of BRCA1 and BRCA2 gene mutations in individuals at high risk for breast and ovarian cancer

2.50
Hdl Handle:
http://hdl.handle.net/10755/161677
Type:
Presentation
Title:
Reliability of statistical tools to predict the likelihood of BRCA1 and BRCA2 gene mutations in individuals at high risk for breast and ovarian cancer
Abstract:
Reliability of statistical tools to predict the likelihood of BRCA1 and BRCA2 gene mutations in individuals at high risk for breast and ovarian cancer
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2000
Author:Hankammer, M.
P.I. Institution Name:Rush-Presbyterian-St. Luke's Medical Center
Title:
Contact Address:1432 W. Harrison St., 2A, Chicago, IL, 60607, USA
Problem: Can statistical tools be reliably used in clinical settings to estimate the likelihood that an individual carries the BRCA1 or BRCA2 gene mutations, which increase the risk of breast and ovarian cancer. Significance: There is an increasing demand for genetic services from individuals who believe they are at high risk of carrying gene mutations. Clinical tools are needed to assist individuals and their families in deciding whether to undergo expensive genetic testing. Method: A retrospective study to test the reliability of several genetic risk tools in predicting the presence of BRCA1 or BRCA2 mutations in a sample of individuals (n=105) with known genotypes. The sample was drawn from tested individuals at two cancer risk centers. Statistical analysis was conducted using SPSS software to determine the correlations between the predicted probability calculated by each tool and actual carrier status. Results: The BRCAPRO program (Parmigiani, et al.) was reliable in predicting the carrier status of those at the highest (>90%) and lowest (<20%) calculated risk (Sensitivity >90%; p<.01). Other tools (Couch, MyriadI, MyriadII) were less reliable, using standard pedigree information. Further research is being conducted to develop criteria for accurately identifying the carrier status of those at moderate calculated risk.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleReliability of statistical tools to predict the likelihood of BRCA1 and BRCA2 gene mutations in individuals at high risk for breast and ovarian canceren_GB
dc.identifier.urihttp://hdl.handle.net/10755/161677-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Reliability of statistical tools to predict the likelihood of BRCA1 and BRCA2 gene mutations in individuals at high risk for breast and ovarian cancer</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2000</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Hankammer, M.</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Rush-Presbyterian-St. Luke's Medical Center</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value"> </td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">1432 W. Harrison St., 2A, Chicago, IL, 60607, USA</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value"> </td></tr><tr><td colspan="2" class="item-abstract">Problem: Can statistical tools be reliably used in clinical settings to estimate the likelihood that an individual carries the BRCA1 or BRCA2 gene mutations, which increase the risk of breast and ovarian cancer. Significance: There is an increasing demand for genetic services from individuals who believe they are at high risk of carrying gene mutations. Clinical tools are needed to assist individuals and their families in deciding whether to undergo expensive genetic testing. Method: A retrospective study to test the reliability of several genetic risk tools in predicting the presence of BRCA1 or BRCA2 mutations in a sample of individuals (n=105) with known genotypes. The sample was drawn from tested individuals at two cancer risk centers. Statistical analysis was conducted using SPSS software to determine the correlations between the predicted probability calculated by each tool and actual carrier status. Results: The BRCAPRO program (Parmigiani, et al.) was reliable in predicting the carrier status of those at the highest (&gt;90%) and lowest (&lt;20%) calculated risk (Sensitivity &gt;90%; p&lt;.01). Other tools (Couch, MyriadI, MyriadII) were less reliable, using standard pedigree information. Further research is being conducted to develop criteria for accurately identifying the carrier status of those at moderate calculated risk.</td></tr></table>en_GB
dc.date.available2011-10-26T23:25:22Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:25:22Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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