Effects of resistance exercise training on muscle mass and muscle protein content in tumor bearing mice

2.50
Hdl Handle:
http://hdl.handle.net/10755/161682
Type:
Presentation
Title:
Effects of resistance exercise training on muscle mass and muscle protein content in tumor bearing mice
Abstract:
Effects of resistance exercise training on muscle mass and muscle protein content in tumor bearing mice
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2001
Author:Al-Majid, Sadeeka,
P.I. Institution Name:Virginia Commonwealth University
Title:Assistant Professor
Contact Address:School of Nursing, 1220 East Broad Street, PO Box 980567, Richmond, VA, 23298-0567, USA
Contact Telephone:804.828.3447
Progressive wasting of skeletal muscle is a significant consequence of malignant tumor growth. Perturbations in protein metabolism contribute to muscle wasting. Resistance exercise counteracts muscle wasting associated with a variety of conditions. It is not known if resistance exercise will counteract muscle wasting associated with malignancy. This study examined the effect of resistance exercise training on muscle mass and protein content in tumor-bearing mice. The dorsiflexor (EDL, TA) and plantar flexor (SO, PL, Gastroc) muscles of one leg were stimulated to contract eccentrically and concentrically, respectively, using an electrical stimulation protocol consisting of 10 sets of 6 repetitions per session. Muscles were stimulated on alternate days for 8 sessions. Healthy control mice were trained in a manner identical to that of the tumor mice. Weight and protein content of stimulated EDL muscle in tumor mice were significantly higher than those of the contralateral non-stimulated EDL muscle. The stimulation protocol did not have significant effects on weight or protein content of TA, SO, PL, or Gastroc muscles in tumor-bearing or control mice. These results suggest that the stimulation protocol had differential effects on different muscles and that eccentric contractions appear to be more effective than concentric contractions in attenuating cancer-related muscle wasting.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleEffects of resistance exercise training on muscle mass and muscle protein content in tumor bearing miceen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161682-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Effects of resistance exercise training on muscle mass and muscle protein content in tumor bearing mice</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2001</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Al-Majid, Sadeeka, </td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Virginia Commonwealth University</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">School of Nursing, 1220 East Broad Street, PO Box 980567, Richmond, VA, 23298-0567, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">804.828.3447</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">salmaji1@vcu.edu</td></tr><tr><td colspan="2" class="item-abstract">Progressive wasting of skeletal muscle is a significant consequence of malignant tumor growth. Perturbations in protein metabolism contribute to muscle wasting. Resistance exercise counteracts muscle wasting associated with a variety of conditions. It is not known if resistance exercise will counteract muscle wasting associated with malignancy. This study examined the effect of resistance exercise training on muscle mass and protein content in tumor-bearing mice. The dorsiflexor (EDL, TA) and plantar flexor (SO, PL, Gastroc) muscles of one leg were stimulated to contract eccentrically and concentrically, respectively, using an electrical stimulation protocol consisting of 10 sets of 6 repetitions per session. Muscles were stimulated on alternate days for 8 sessions. Healthy control mice were trained in a manner identical to that of the tumor mice. Weight and protein content of stimulated EDL muscle in tumor mice were significantly higher than those of the contralateral non-stimulated EDL muscle. The stimulation protocol did not have significant effects on weight or protein content of TA, SO, PL, or Gastroc muscles in tumor-bearing or control mice. These results suggest that the stimulation protocol had differential effects on different muscles and that eccentric contractions appear to be more effective than concentric contractions in attenuating cancer-related muscle wasting.</td></tr></table>en_GB
dc.date.available2011-10-26T23:25:27Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:25:27Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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