2.50
Hdl Handle:
http://hdl.handle.net/10755/161695
Type:
Presentation
Title:
Exposure to complex environment after cerebral ischemia may be neuroprotective
Abstract:
Exposure to complex environment after cerebral ischemia may be neuroprotective
Conference Sponsor:Midwest Nursing Research Society
Conference Year:2001
Author:Briones, Tess, PhD
P.I. Institution Name:University of Illinois at Chicago
Title:Research Assistant Professor
Contact Address:College of Nursing, 845 South Damen Avenue, M/C 802, 750 NURS, Chicago, IL, 60612, USA
Contact Telephone:312.355.3142
Increased beta-amyloid precursor protein (beta-APP) is seen in cerebral ischemia but it is unclear whether this leads to neuroprotection or neurodegeneration. We examined if: 1) complex environment (EC) exposure after cerebral ischemia affects beta-APP expression; and 2) nerve growth factor (NGF), protein promoting cell survival, expression modulates level of amyloid-beta (A-beta), peptide forming the fibrillar deposit in Alzheimer's diseases. Adult male Wistar rats (n=186) received either ischemia or sham surgery. Rats in each group were randomized to either EC or paired housing (SC). Rats were sacrificed at 1,2,4,7,21 & 28 days after environmental exposure. Immunohistochemical analyses in the hippocampus, brain region involved in memory, showed both ischemic groups and sham EC rats had significant increases in beta-APP and NGF expression. Decreased beta-APP was seen in ischemic EC and sham EC rats after day 7 while beta-APP levels in ischemic SC rats remained significantly elevated until day 21. NGF expression was increased until day 28 in both ischemic groups and in sham EC rats. A-beta expression was significantly elevated in ischemic SC rats until day 21 compared to ischemic EC rats. These results indicate that EC modulates beta-APP expression and that NGF elevation resulting from EC exposure possibly influences A-beta expression.
Repository Posting Date:
26-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Midwest Nursing Research Society

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleExposure to complex environment after cerebral ischemia may be neuroprotectiveen_GB
dc.identifier.urihttp://hdl.handle.net/10755/161695-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Exposure to complex environment after cerebral ischemia may be neuroprotective</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Midwest Nursing Research Society</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">2001</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Briones, Tess, PhD</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">University of Illinois at Chicago</td></tr><tr class="item-author-title"><td class="label">Title:</td><td class="value">Research Assistant Professor</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">College of Nursing, 845 South Damen Avenue, M/C 802, 750 NURS, Chicago, IL, 60612, USA</td></tr><tr class="item-phone"><td class="label">Contact Telephone:</td><td class="value">312.355.3142</td></tr><tr class="item-email"><td class="label">Email:</td><td class="value">tbriones@uic.edu</td></tr><tr><td colspan="2" class="item-abstract">Increased beta-amyloid precursor protein (beta-APP) is seen in cerebral ischemia but it is unclear whether this leads to neuroprotection or neurodegeneration. We examined if: 1) complex environment (EC) exposure after cerebral ischemia affects beta-APP expression; and 2) nerve growth factor (NGF), protein promoting cell survival, expression modulates level of amyloid-beta (A-beta), peptide forming the fibrillar deposit in Alzheimer's diseases. Adult male Wistar rats (n=186) received either ischemia or sham surgery. Rats in each group were randomized to either EC or paired housing (SC). Rats were sacrificed at 1,2,4,7,21 &amp; 28 days after environmental exposure. Immunohistochemical analyses in the hippocampus, brain region involved in memory, showed both ischemic groups and sham EC rats had significant increases in beta-APP and NGF expression. Decreased beta-APP was seen in ischemic EC and sham EC rats after day 7 while beta-APP levels in ischemic SC rats remained significantly elevated until day 21. NGF expression was increased until day 28 in both ischemic groups and in sham EC rats. A-beta expression was significantly elevated in ischemic SC rats until day 21 compared to ischemic EC rats. These results indicate that EC modulates beta-APP expression and that NGF elevation resulting from EC exposure possibly influences A-beta expression.</td></tr></table>en_GB
dc.date.available2011-10-26T23:25:42Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-26T23:25:42Z-
dc.description.sponsorshipMidwest Nursing Research Societyen_GB
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