2.50
Hdl Handle:
http://hdl.handle.net/10755/162780
Type:
Presentation
Title:
Seizure Activity Related to Dilantin and Albumin Levels
Abstract:
Seizure Activity Related to Dilantin and Albumin Levels
Conference Sponsor:Emergency Nurses Association
Conference Year:1998
Author:Crowder, Karen M., RN, BSN, CEN, CCRN
P.I. Institution Name:Parkland Memorial Hospital
Contact Address:, Dallas, TX, USA
Purpose: Uncontrolled seizure patients return to the emergency department (ED) on average, seven times a year, with an average cost a visit of $582.00. The total average cost per seizure patient is $4,074 a year for seizure activity in the ED. The objective of this research study is to determine the pharmacokinetic reasons for return visits of seizure patients to the ED. Serum albumin is seen as a factor in monitoring dilantin therapy. Therefore, the research question is, "Is there a positive relationship between albumin levels and dilantin levels in clients with seizure disorders?"

Design/Setting: This study will be a retrospective chart review at a 66-bed emergency department, level I county, urban hospital in Texas.

Sample: The charts of 433 seizure patients admitted to the emergency department from October 1, 1996, to September 30, 1997, are available for review. The epilepsy nurse clinician and department supervisors have given permission to utilize laboratory results from these charts. No personal identities will be recorded, as only medical record numbers and laboratory results will be used.

Methodology: A relationship will be established between these levels by comparing free (unbound) dilantin levels to the ratio between total dilantin levels and albumin levels which are obtained through venipuncture. Specific procedures and analytic strategies include gathering laboratory results of serum free dilantin levels, serum total dilantin levels, and serum albumin levels. The results will then compare the amount of serum free dilantin level as compared to the ratio of serum total dilantin and serum albumin levels.

Results: In clients with normal to elevated albumin levels, dilantin dosing should be done by monitoring total dilantin and the total albumin ratio. In clients with hypoalbuminemia or a significant organ disorder or disease, serum free dilantin is a better monitoring level for dosing.

Conclusions: The study may demonstrate that continuous monitoring of serum albumin/total dilantin ratios in primary care or neurology clinics may prevent admission to the emergency department with uncontrolled seizures on medication, which is costly to the client and the health care facility. [Research Poster Presentation]
Repository Posting Date:
27-Oct-2011
Date of Publication:
17-Oct-2011
Sponsors:
Emergency Nurses Association

Full metadata record

DC FieldValue Language
dc.typePresentationen_GB
dc.titleSeizure Activity Related to Dilantin and Albumin Levelsen_GB
dc.identifier.urihttp://hdl.handle.net/10755/162780-
dc.description.abstract<table><tr><td colspan="2" class="item-title">Seizure Activity Related to Dilantin and Albumin Levels</td></tr><tr class="item-sponsor"><td class="label">Conference Sponsor:</td><td class="value">Emergency Nurses Association</td></tr><tr class="item-year"><td class="label">Conference Year:</td><td class="value">1998</td></tr><tr class="item-author"><td class="label">Author:</td><td class="value">Crowder, Karen M., RN, BSN, CEN, CCRN</td></tr><tr class="item-institute"><td class="label">P.I. Institution Name:</td><td class="value">Parkland Memorial Hospital</td></tr><tr class="item-address"><td class="label">Contact Address:</td><td class="value">, Dallas, TX, USA</td></tr><tr><td colspan="2" class="item-abstract">Purpose: Uncontrolled seizure patients return to the emergency department (ED) on average, seven times a year, with an average cost a visit of $582.00. The total average cost per seizure patient is $4,074 a year for seizure activity in the ED. The objective of this research study is to determine the pharmacokinetic reasons for return visits of seizure patients to the ED. Serum albumin is seen as a factor in monitoring dilantin therapy. Therefore, the research question is, &quot;Is there a positive relationship between albumin levels and dilantin levels in clients with seizure disorders?&quot;<br/><br/>Design/Setting: This study will be a retrospective chart review at a 66-bed emergency department, level I county, urban hospital in Texas.<br/><br/> Sample: The charts of 433 seizure patients admitted to the emergency department from October 1, 1996, to September 30, 1997, are available for review. The epilepsy nurse clinician and department supervisors have given permission to utilize laboratory results from these charts. No personal identities will be recorded, as only medical record numbers and laboratory results will be used.<br/><br/>Methodology: A relationship will be established between these levels by comparing free (unbound) dilantin levels to the ratio between total dilantin levels and albumin levels which are obtained through venipuncture. Specific procedures and analytic strategies include gathering laboratory results of serum free dilantin levels, serum total dilantin levels, and serum albumin levels. The results will then compare the amount of serum free dilantin level as compared to the ratio of serum total dilantin and serum albumin levels. <br/><br/>Results: In clients with normal to elevated albumin levels, dilantin dosing should be done by monitoring total dilantin and the total albumin ratio. In clients with hypoalbuminemia or a significant organ disorder or disease, serum free dilantin is a better monitoring level for dosing.<br/><br/>Conclusions: The study may demonstrate that continuous monitoring of serum albumin/total dilantin ratios in primary care or neurology clinics may prevent admission to the emergency department with uncontrolled seizures on medication, which is costly to the client and the health care facility. [Research Poster Presentation]</td></tr></table>en_GB
dc.date.available2011-10-27T10:34:01Z-
dc.date.issued2011-10-17en_GB
dc.date.accessioned2011-10-27T10:34:01Z-
dc.description.sponsorshipEmergency Nurses Associationen_GB
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