7-Month Outcomes of Infants Enrolled in a Randomized Controlled Trial of Delayed versus Immediate Cord Clamping

2.50
Hdl Handle:
http://hdl.handle.net/10755/163146
Category:
Abstract
Type:
Presentation
Title:
7-Month Outcomes of Infants Enrolled in a Randomized Controlled Trial of Delayed versus Immediate Cord Clamping
Author(s):
Mercer, Judith S.; Erickson-Owens, Debra A.
Author Details:
Judith S. Mercer, DNSc, CNM, University of Rhode Island, Kingston, Rhode Island, USA, email: jmercer@uri.edu; Debra A. Erickson-Owens
Abstract:
Purpose: Delaying cord clamping (DCC) briefly in very low birth weight (VLBW) preterm infants has been shown to result in increased blood volume at birth. Results from our randomized controlled trial revealed that infants in the DCC group had significantly less intra-ventricular hemorrhage (IVH) and late onset sepsis (LOS) than infants in the immediate clamped group (ICC). A priori, we hypothesized that VLBW infants with DCC would have better motor function by 7 months corrected age (CA). Theoretical Framework: VLBW infants have high risk of developmental delay and abnormal motor function. Their vulnerability may be increased by low blood volume. DCC may offer protection by providing more red blood and stem cells in the infant's circulation. Methods (Design, Sample, Setting, Measures, Analysis): VLBW infants between 24 and 31.6 weeks were randomized to either ICC or DCC. Follow-up evaluation at 7 months CA included administration of Bayley Scales of Infant Development, Psychomotor Developmental Index (BSID, PDI) by evaluators blinded to the infant's group assignment. Secondary analyses were done to assess possible effects of a conservative initial transfusion. Results: There were 36 infants each in the DCC and the ICC groups. There were no differences in maternal or infant demographic or initial clinical variables. Fifty-seven children were administered the BSID, PDI at approximately 7-months corrected age. Results showed that there were no differences between the groups in the BSID scores. However, infants who had been transfused initially with conservative amounts (< 13 mL/kg) had lower BSID scores and longer length of stay than those infants transfused with larger amounts (> 13 mL/kg). Conclusions and Implications: Delaying the cord clamping did not result in improved motor outcomes at 7 months of age. Our findings suggest that lower amounts of blood transfused initially may negate or confound positive effects at 7 mo. CA from delayed cord clamping at birth in VLBW infants.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2007
Conference Name:
19th Annual Scientific Sessions
Conference Host:
Eastern Nursing Research Society
Conference Location:
Providence, Rhode Island, USA
Description:
Conference theme: Building Communities of Scholarship and Research, held April 12-14, 2007 at The Westin Providence.
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.title7-Month Outcomes of Infants Enrolled in a Randomized Controlled Trial of Delayed versus Immediate Cord Clampingen_GB
dc.contributor.authorMercer, Judith S.en_US
dc.contributor.authorErickson-Owens, Debra A.en_US
dc.author.detailsJudith S. Mercer, DNSc, CNM, University of Rhode Island, Kingston, Rhode Island, USA, email: jmercer@uri.edu; Debra A. Erickson-Owensen_US
dc.identifier.urihttp://hdl.handle.net/10755/163146-
dc.description.abstractPurpose: Delaying cord clamping (DCC) briefly in very low birth weight (VLBW) preterm infants has been shown to result in increased blood volume at birth. Results from our randomized controlled trial revealed that infants in the DCC group had significantly less intra-ventricular hemorrhage (IVH) and late onset sepsis (LOS) than infants in the immediate clamped group (ICC). A priori, we hypothesized that VLBW infants with DCC would have better motor function by 7 months corrected age (CA). Theoretical Framework: VLBW infants have high risk of developmental delay and abnormal motor function. Their vulnerability may be increased by low blood volume. DCC may offer protection by providing more red blood and stem cells in the infant's circulation. Methods (Design, Sample, Setting, Measures, Analysis): VLBW infants between 24 and 31.6 weeks were randomized to either ICC or DCC. Follow-up evaluation at 7 months CA included administration of Bayley Scales of Infant Development, Psychomotor Developmental Index (BSID, PDI) by evaluators blinded to the infant's group assignment. Secondary analyses were done to assess possible effects of a conservative initial transfusion. Results: There were 36 infants each in the DCC and the ICC groups. There were no differences in maternal or infant demographic or initial clinical variables. Fifty-seven children were administered the BSID, PDI at approximately 7-months corrected age. Results showed that there were no differences between the groups in the BSID scores. However, infants who had been transfused initially with conservative amounts (< 13 mL/kg) had lower BSID scores and longer length of stay than those infants transfused with larger amounts (> 13 mL/kg). Conclusions and Implications: Delaying the cord clamping did not result in improved motor outcomes at 7 months of age. Our findings suggest that lower amounts of blood transfused initially may negate or confound positive effects at 7 mo. CA from delayed cord clamping at birth in VLBW infants.en_GB
dc.date.available2011-10-27T11:02:10Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T11:02:10Z-
dc.conference.date2007en_US
dc.conference.name19th Annual Scientific Sessionsen_US
dc.conference.hostEastern Nursing Research Societyen_US
dc.conference.locationProvidence, Rhode Island, USAen_US
dc.descriptionConference theme: Building Communities of Scholarship and Research, held April 12-14, 2007 at The Westin Providence.en_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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